publications

selected publications by categories in reversed chronological order. generated by jekyll-scholar.

  1. Aalkjaer, C., & Hughes, A. (1991). Chloride and bicarbonate transport in rat resistance arteries [Journal Article]. J Physiol, 436, 57–73. http://www.ncbi.nlm.nih.gov/pubmed/2061847
  2. Achour, M., Jacq, X., Ronde, P., Alhosin, M., Charlot, C., Chataigneau, T., Jeanblanc, M., Macaluso, M., Giordano, A., Hughes, A. D., Schini-Kerth, V. B., & Bronner, C. (2008). The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression [Journal Article]. Oncogene, 27(15), 2187–2197. https://doi.org/10.1038/sj.onc.1210855
  3. Aguado-Sierra, J., Davies, J. E., Hadjiloizou, N., Francis, D., Mayet, J., Hughes, A. D., & Parker, K. H. (2008). Reservoir-wave separation and wave intensity analysis applied to carotid arteries: a hybrid 1D model to understand haemodynamics [Journal Article]. Conf Proc IEEE Eng Med Biol Soc, 2008, 1381–1384. https://doi.org/10.1109/IEMBS.2008.4649422
  4. Aguado-Sierra, J., Parker, K. H., Davies, J. E., Francis, D., Hughes, A. D., & Mayet, J. (2006). Arterial pulse wave velocity in coronary arteries [Journal Article]. Conf Proc IEEE Eng Med Biol Soc, 1, 867–870. https://doi.org/10.1109/IEMBS.2006.259375
  5. Ahmadi, M. N., Blodgett, J. M., Atkin, A. J., Chan, H. W., Del Pozo Cruz, B., Suorsa, K., Bakker, E. A., Pulsford, R. M., Mielke, G. I., Johansson, P. J., Hettiarachchi, P., Thijssen, D. H. J., Stenholm, S., Mishra, G. D., Teixeira-Pinot, A., Rangul, V., Sherar, L. B., Ekelund, U., Hughes, A. D., … Stamatakis, E. (2024). Relationship of device measured physical activity type and posture with cardiometabolic health markers: pooled dose-response associations from the Prospective Physical Activity, Sitting and Sleep Consortium [Journal Article]. Diabetologia. https://doi.org/10.1007/s00125-024-06090-y
  6. Aizawa, K., Casanova, F., Gates, P. E., Mawson, D. M., Gooding, K. M., Strain, W. D., Ostling, G., Nilsson, J., Khan, F., Colhoun, H. M., Palombo, C., Parker, K. H., Shore, A. C., & Hughes, A. D. (2021). Reservoir-Excess Pressure Parameters Independently Predict Cardiovascular Events in Individuals With Type 2 Diabetes [Journal Article]. Hypertension, 78(1), 40–50. https://doi.org/10.1161/HYPERTENSIONAHA.121.17001
  7. Aizawa, K., Hughes, A. D., Casanova, F., Gates, P. E., Mawson, D. M., Gooding, K. M., Gilchrist, M., Goncalves, I., Nilsson, J., Khan, F., Colhoun, H. M., Palombo, C., Parker, K. H., & Shore, A. C. (2022). Reservoir Pressure Integral Is Independently Associated With the Reduction in Renal Function in Older Adults [Journal Article]. Hypertension, 79(10), 2364–2372. https://doi.org/10.1161/HYPERTENSIONAHA.122.19483
  8. Aizawa, K., Jordan, A. N., Gooding, K. M., Llewellyn, D. J., Mawson, D. M., Casanova, F., Gates, P. E., Adingupu, D. D., Elyas, S., Hope, S. V., Gilchrist, M., Strain, W. D., Clark, C. E., Bellenger, N. G., Sharp, A. S. P., Parker, K. H., Hughes, A. D., & Shore, A. C. (2024). Aortic reservoir-excess pressure parameters are associated with worse cognitive function in people with untreated stage II/III hypertension [Journal Article]. J Hypertens, 42(12), 2139–2147. https://doi.org/10.1097/HJH.0000000000003853
  9. Al Saikhan, L., Alobaida, M., Bhuva, A., Chaturvedi, N., Heasman, J., Hughes, A. D., Jones, S., Eastwood, S., Manisty, C., March, K., Ghosh, A. K., Mayet, J., Oguntade, A., Tillin, T., Williams, S., Wright, A., & Park, C. (2020). Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study [Journal Article]. Front Cardiovasc Med, 7, 591946. https://doi.org/10.3389/fcvm.2020.591946
  10. Al Saikhan, L., Alobaida, M., Bhuva, A., Chaturvedi, N., Heasman, J., Hughes, A. D., Jones, S., Eastwood, S., Manisty, C., March, K., Ghosh, A. K., Mayet, J., Oguntade, A., Tillin, T., Williams, S., Wright, A., & Park, C. (2021). Corrigendum: Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study [Journal Article]. Front Cardiovasc Med, 8, 769050. https://doi.org/10.3389/fcvm.2021.769050
  11. Al Saikhan, L., Chaturvedi, N., Ghosh, A. K., Hardy, R., & Hughes, A. (2024). Adulthood adiposity affects cardiac structure and function in later life [Journal Article]. Eur Heart J, 45(33), 3060–3068. https://doi.org/10.1093/eurheartj/ehae403
  12. Al Saikhan, L., Hughes, A. D., Chung, W. S., Alsharqi, M., & Nihoyannopoulos, P. (2019). Left atrial function in heart failure with mid-range ejection fraction differs from that of heart failure with preserved ejection fraction: a 2D speckle-tracking echocardiographic study [Journal Article]. Eur Heart J Cardiovasc Imaging, 20(3), 279–290. https://doi.org/10.1093/ehjci/jey171
  13. Al Saikhan, L., Park, C., Hardy, R., & Hughes, A. (2019). Prognostic implications of left ventricular strain by speckle-tracking echocardiography in the general population: a meta-analysis [Journal Article]. Vasc Health Risk Manag, 15, 229–251. https://doi.org/10.2147/VHRM.S206747
  14. Al Saikhan, L., Park, C., & Hughes, A. D. (2019). Reproducibility of Left Ventricular Dyssynchrony Indices by Three-Dimensional Speckle-Tracking Echocardiography: The Impact of Sub-optimal Image Quality [Journal Article]. Front Cardiovasc Med, 6, 149. https://doi.org/10.3389/fcvm.2019.00149
  15. Al Saikhan, L., Park, C., Tillin, T., Jones, S., Francis, D., Mayet, J., Chaturvedi, N., & Hughes, A. D. (2023). Sex-differences in associations of LV structure and function measured by echocardiography with long-term risk of mortality and cardiovascular morbidity [Journal Article]. Frontiers in Cardiovascular Medicine, 10. https://doi.org/10.3389/fcvm.2023.1144964
  16. Al Saikhan, L., Park, C., Tillin, T., Jones, S., Mayet, J., Chaturvedi, N., & Hughes, A. (2023). Does 3D-speckle tracking echocardiography improve prediction of major cardiovascular events in a multi-ethnic general population? A Southall and Brent Revisited (SABRE) cohort study [Journal Article]. PLoS One, 18(6), e0287173. https://doi.org/10.1371/journal.pone.0287173
  17. Al Saikhan, L., Park, C., Tillin, T., Lloyd, G., Mayet, J., Chaturvedi, N., & Hughes, A. D. (2022). Relationship Between Image Quality and Bias in 3D Echocardiographic Measures: Data From the SABRE (Southall and Brent Revisited) Study [Journal Article]. J Am Heart Assoc, 11(9), e019183. https://doi.org/10.1161/JAHA.120.019183
  18. Alfarih, M., Augusto, J. B., Knott, K. D., Fatih, N., Kumar, M. P., Boubertakh, R., Hughes, A. D., Moon, J. C., Weingartner, S., & Captur, G. (2022). Saturation-pulse prepared heart-rate independent inversion-recovery (SAPPHIRE) biventricular T1 mapping: inter-field strength, head-to-head comparison of diastolic, systolic and dark-blood measurements [Journal Article]. BMC Med Imaging, 22(1), 122. https://doi.org/10.1186/s12880-022-00843-0
  19. Anbar, R., Jones, S., Chaturvedi, N., Sudre, C., Richards, M., Sultan, S. R., & Hughes, A. D. (2024). Associations of carotid atherosclerosis with cognitive function and brain health: Findings from a UK tri-ethnic cohort study (Southall and Brent Revisited) [Journal Article]. Atheroscler Plus, 55, 39–46. https://doi.org/10.1016/j.athplu.2024.01.002
  20. Anbar, R., Sultan, S. R., Al Saikhan, L., Alkharaiji, M., Chaturvedi, N., Hardy, R., Richards, M., & Hughes, A. (2022). Is carotid artery atherosclerosis associated with poor cognitive function assessed using the Mini-Mental State Examination? A systematic review and meta-analysis [Journal Article]. BMJ Open, 12(4), e055131. https://doi.org/10.1136/bmjopen-2021-055131
  21. Ariff, B., Stanton, A., Barratt, D., Augst, A., Glor, F., Poulter, N., Sever, P., Xu, Y., Hughes, A., & Thom, S. A. (2002). Comparison of the effects of antihypertensive treatment with angiotensin II blockade and beta-blockade on carotid wall structure and haemodynamics: protocol and baseline demographics [Journal Article]. J Renin Angiotensin Aldosterone Syst, 3(2), 116–122. https://doi.org/10.3317/jraas.2002.012
  22. Ariff, B., Zambanini, A., Vamadeva, S., Barratt, D., Xu, Y., Sever, P., Stanton, A., Hughes, A., & Thom, S. (2006). Candesartan- and atenolol-based treatments induce different patterns of carotid artery and left ventricular remodeling in hypertension [Journal Article]. Stroke, 37(9), 2381–2384. https://doi.org/10.1161/01.STR.0000236839.69658.c5
  23. Ariff, B. B., Glor, F. P., Crowe, L., Xu, X. Y., Vennart, W., Firmin, D. N., Thom, S. M., & Hughes, A. D. (2010). Carotid artery hemodynamics: observing patient-specific changes with amlodipine and lisinopril by using MR imaging computation fluid dynamics [Journal Article]. Radiology, 257(3), 662–669. https://doi.org/10.1148/radiol.10100788
  24. Armstrong, M. K., Schultz, M. G., Hughes, A. D., Picone, D. S., Black, J. A., Dwyer, N., Roberts-Thomson, P., & Sharman, J. E. (2021). Excess pressure as an analogue of blood flow velocity [Journal Article]. J Hypertens, 39(3), 421–427. https://doi.org/10.1097/HJH.0000000000002662
  25. Armstrong, M. K., Schultz, M. G., Hughes, A. D., Picone, D. S., & Sharman, J. E. (2021). Physiological and clinical insights from reservoir-excess pressure analysis [Journal Article]. J Hum Hypertens, 35(9), 758–768. https://doi.org/10.1038/s41371-021-00515-6
  26. Augst, A. D., Ariff, B., Barratt, D. C., Thom, S. A. M. G., Hughes, A. D., & Xu, X. Y. (2005). Application of ultrasound-based computational fluid dynamics to modeling blood flow in the carotid bifurcation [Book Section]. In C. T. Leondes (Ed.), Medical Imaging Systems Technology: Methods in Cardiovascular And Brain Systems (pp. 109–156). World Scientific Publishing Co.
  27. Augst, A. D., Ariff, B., Thom, S. A. M. G., Xu, X. Y., & Hughes, A. D. (2007). Analysis of complex flow and the relationship between blood pressure, wall shear stress, and intima-media thickness in the human carotid artery [Journal Article]. Am J Physiol Heart Circ Physiol, 293(2), H1031–7. https://doi.org/10.1152/ajpheart.00989.2006
  28. Augst, A. D., Barratt, D. C., Hughes, A. D., Glor, F. P., Thom, S. A. M. G., & Xu, X. Y. (2003). Accuracy and reproducibility of CFD predicted wall shear stress using 3D ultrasound images [Journal Article]. Journal of Biomechanical Engineering, 125(2), 218–222. https://doi.org/10.1115/1.1553973
  29. Augst, A. D., Barratt, D. C., Hughes, A. D., Thom, S. A., & Xu, X. Y. (2003). Various issues relating to computational fluid dynamics simulations of carotid bifurcation flow based on models reconstructed from three-dimensional ultrasound images [Journal Article]. Proc Inst Mech Eng H, 217(5), 393–403. https://doi.org/10.1243/095441103770802568
  30. Augusto, J. B., Knott, K., Bhuva, A., Lau, C., Nordin, S., Bwalya, M., Hughes, R., Seraphim, A., Al-Farih, M., D’Silva, A., Torlasco, C., Nadarajan, N., Vijapurapu, R., Treibel, T. T., Captur, G., Ramaswami, U., Hughes, A., Kozor, R., Sharma, S., … Moon, J. C. (2020). The Fabry cardiovascular phenotype: Aortic stiffness in Fabry disease is linked to left ventricular hypertrophy and myocardial inflammation but not storage or fibrosis [Journal Article]. Molecular Genetics and Metabolism, 129(2), S23–S23. https://doi.org/10.1016/j.ymgme.2019.11.030
  31. Baksi, A. J., Davies, J. E., Hadjiloizou, N., Baruah, R., Unsworth, B., Foale, R. A., Korolkova, O., Siggers, J. H., Francis, D. P., Mayet, J., Parker, K. H., & Hughes, A. D. (2016). Attenuation of reflected waves in man during retrograde propagation from femoral artery to proximal aorta [Journal Article]. Int J Cardiol, 202, 441–445. https://doi.org/10.1016/j.ijcard.2015.09.064
  32. Baksi, A. J., Treibel, T. A., Davies, J. E., Hadjiloizou, N., Foale, R. A., Parker, K. H., Francis, D. P., Mayet, J., & Hughes, A. D. (2009). A meta-analysis of the mechanism of blood pressure change with aging [Journal Article]. J Am Coll Cardiol, 54(22), 2087–2092. https://doi.org/10.1016/j.jacc.2009.06.049
  33. Baksi, A. J., Treibel, T. A., Davies, J. E., Hadjiloizou, N., Foale, R. A., Parker, K. H., Francis, D. P., Mayet, J., & Hughes, A. D. (2010). Changes in the Central Arterial Pressure Pulse With Aging Reply [Journal Article]. J Am Coll Cardiol, 55(19), 2183–2184. https://doi.org/DOI 10.1016/j.jacc.2010.02.022
  34. Bann, D., Villadsen, A., Maddock, J., Hughes, A., Ploubidis, G. B., Silverwood, R., & Patalay, P. (2021). Changes in the behavioural determinants of health during the COVID-19 pandemic: gender, socioeconomic and ethnic inequalities in five British cohort studies [Journal Article]. J Epidemiol Community Health. https://doi.org/10.1136/jech-2020-215664
  35. Bann, D., Wright, L., Hughes, A., & Chaturvedi, N. (2023). Socioeconomic inequalities in cardiovascular disease: a causal perspective [Journal Article]. Nat Rev Cardiol. https://doi.org/10.1038/s41569-023-00941-8
  36. Barratt, D. C., Ariff, B. B., Humphries, K. N., Thom, S. A., & Hughes, A. D. (2004). Reconstruction and quantification of the carotid artery bifurcation from 3-D ultrasound images [Journal Article]. IEEE Trans Med Imaging, 23(5), 567–583. https://doi.org/10.1109/TMI.2004.825601
  37. Barratt, D. C., Davies, A. H., Hughes, A. D., Thom, S. A., & Humphries, K. N. (2001). Accuracy of an electromagnetic three-dimensional ultrasound system for carotid artery imaging [Journal Article]. Ultrasound Med Biol, 27(10), 1421–1425. http://www.ncbi.nlm.nih.gov/pubmed/11731055 http://ac.els-cdn.com/S0301562901004471/1-s2.0-S0301562901004471-main.pdf?_tid=b780522a-4589-11e4-ab03-00000aacb360&acdnat=1411742032_5561339e62564132fe3f244c02e8f03d
  38. Barratt, D. C., Davies, A. H., Hughes, A. D., Thom, S. A., & Humphries, K. N. (2001). Optimisation and evaluation of an electromagnetic tracking device for high-accuracy three-dimensional ultrasound imaging of the carotid arteries [Journal Article]. Ultrasound Med Biol, 27(7), 957–968. http://www.ncbi.nlm.nih.gov/pubmed/11476930 http://ac.els-cdn.com/S0301562901003957/1-s2.0-S0301562901003957-main.pdf?_tid=b41b0792-4589-11e4-8bfd-00000aacb35e&acdnat=1411742026_91abb9616ca5da9f01dd0a6ab8d520d2
  39. Barron, A., Dhutia, N., Mayet, J., Hughes, A. D., Francis, D. P., & Wensel, R. (2014). Response to editorial ’reproducibility of cardiopulmonary exercise test variables: getting into an additional strength of the test’ [Journal Article]. Eur J Prev Cardiol, 21(4), 454–455. https://doi.org/10.1177/2047487314526683
  40. Barron, A., Dhutia, N., Mayet, J., Hughes, A. D., Francis, D. P., & Wensel, R. (2014). Test-retest repeatability of cardiopulmonary exercise test variables in patients with cardiac or respiratory disease [Journal Article]. Eur J Prev Cardiol, 21(4), 445–453. https://doi.org/10.1177/2047487313518474
  41. Barron, A., Francis, D. P., Mayet, J., Ewert, R., Obst, A., Mason, M., Elkin, S., Hughes, A. D., & Wensel, R. (2016). Oxygen Uptake Efficiency Slope and Breathing Reserve, Not Anaerobic Threshold, Discriminate Between Patients With Cardiovascular Disease Over Chronic Obstructive Pulmonary Disease [Journal Article]. JACC Heart Fail, 4(4), 252–261. https://doi.org/10.1016/j.jchf.2015.11.003
  42. Barron, A. J., Hughes, A. D., Sharp, A., Baksi, A. J., Surendran, P., Jabbour, R. J., Stanton, A., Poulter, N., Fitzgerald, D., Sever, P., O’Brien, E., Thom, S., & Mayet, J. (2014). Long-term antihypertensive treatment fails to improve E/e’ despite regression of left ventricular mass: an Anglo-Scandinavian cardiac outcomes trial substudy [Journal Article]. Hypertension, 63(2), 252–258. https://doi.org/10.1161/HYPERTENSIONAHA.113.01360
  43. Baruah, R., Giannoni, A., Willson, K., Manisty, C. H., Mebrate, Y., Kyriacou, A., Yadav, H., Unsworth, B., Sutton, R., Mayet, J., Hughes, A. D., & Francis, D. P. (2014). Novel cardiac pacemaker-based human model of periodic breathing to develop real-time, pre-emptive technology for carbon dioxide stabilisation [Journal Article]. Open Heart, 1(1), e000055. https://doi.org/10.1136/openhrt-2014-000055
  44. Baruah, R., Giannoni, A., Willson, K., Mebrate, Y., Mayet, J., Emdin, M., Hughes, A. D., Manisty, C. H., & Francis, D. P. (2011). Real-Time Dynamic Carbon Dioxide Administration Reply [Journal Article]. J Am Coll Cardiol, 57(17), 1789–1790. https://doi.org/10.1016/j.jacc.2011.01.017
  45. Bathula, R., Francis, D. P., Hughes, A., & Chaturvedi, N. (2008). Ethnic differences in heart rate: can these be explained by conventional cardiovascular risk factors? [Journal Article]. Clin Auton Res, 18(2), 90–95. https://doi.org/10.1007/s10286-008-0463-2
  46. Bathula, R., Hughes, A. D., Panerai, R., Potter, J., Thom, S. A., Francis, D. P., Shore, A. C., Kooner, J., & Chaturvedi, N. (2010). Indian Asians have poorer cardiovascular autonomic function than Europeans: this is due to greater hyperglycaemia and may contribute to their greater risk of heart disease [Journal Article]. Diabetologia, 53(10), 2120–2128. https://doi.org/10.1007/s00125-010-1818-5
  47. Bathula, R., Hughes, A. D., Panerai, R. B., Potter, J. F., Mc, G. T. S. A., Tillin, T., Shore, A. C., Hale, R., Chambers, J., Kooner, J., & Chaturvedi, N. (2011). South Asians have adverse cerebrovascular haemodynamics, despite equivalent blood pressure, compared with Europeans. This is due to their greater hyperglycaemia [Journal Article]. Int J Epidemiol, 40(6), 1490–1498. https://doi.org/10.1093/ije/dyr101
  48. Bennett, J., van Dinther, M., Voorter, P., Backes, W., Barnes, J., Barkhof, F., Captur, G., Hughes, A. D., Sudre, C., & Treibel, T. A. (2023). Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease [Journal Article]. Medicina (Kaunas), 59(9). https://doi.org/10.3390/medicina59091596
  49. Beros, A. L., Sluyter, J. D., Hughes, A. D., Hametner, B., Wassertheurer, S., & Scragg, R. (2025). Positive association of oscillometrically estimated baseline arterial stiffness with incident diabetes and prediabetes: A large population-based cohort study [Journal Article]. Prim Care Diabetes, 19(1), 66–73. https://doi.org/10.1016/j.pcd.2024.12.006
  50. Beros, A. L., Sluyter, J. D., Hughes, A. D., Hametner, B., Wassertheurer, S., & Scragg, R. K. R. (2024). Arterial Stiffness and Incident Glaucoma: A Large Population-Based Cohort Study [Journal Article]. Am J Ophthalmol, 266, 68–76. https://doi.org/10.1016/j.ajo.2024.05.015
  51. Beulens, J. W. J., Patel, A., Vingerling, J. R., Cruickshank, J. K., Hughes, A. D., Stanton, A., Lu, J., Mcg Thom, S. A., Grobbee, D. E., & Stolk, R. P. (2009). Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus: a randomised controlled trial [Journal Article]. Diabetologia, 52(10), 2027–2036. https://doi.org/10.1007/s00125-009-1457-x
  52. Beulens, J. W. J., Patel, A., Vingerling, J. R., Cruickshank, J. K., Hughes, A. D., Stanton, A., Lu, J., Thom, S. A. M. G., Grobbee, D. E., & Stolk, R. P. (2009). Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus: a randomised controlled trial [Journal Article]. Diabetologia, 52(10), 2027–2036. https://doi.org/10.1007/s00125-009-1457-x
  53. Bhuva, A. N., Bai, W., Lau, C., Davies, R. H., Ye, Y., Bulluck, H., McAlindon, E., Culotta, V., Swoboda, P. P., Captur, G., Treibel, T. A., Augusto, J. B., Knott, K. D., Seraphim, A., Cole, G. D., Petersen, S. E., Edwards, N. C., Greenwood, J. P., Bucciarelli-Ducci, C., … Manisty, C. H. (2019). A Multicenter, Scan-Rescan, Human and Machine Learning CMR Study to Test Generalizability and Precision in Imaging Biomarker Analysis [Journal Article]. Circ Cardiovasc Imaging, 12(10), e009214. https://doi.org/10.1161/CIRCIMAGING.119.009214
  54. Bhuva, A. N., D’Silva, A., Hughes, A. D., Moon, J. C., & Manisty, C. H. (2020). Reply: Rejuvenating Pheidippides and the Evergreen Benefits of Endurance Training [Journal Article]. J Am Coll Cardiol, 75(17), 2278–2279. https://doi.org/10.1016/j.jacc.2020.03.013
  55. Bhuva, A. N., D’Silva, A., Torlasco, C., Jones, S., Nadarajan, N., Van Zalen, J., Chaturvedi, N., Lloyd, G., Sharma, S., Moon, J. C., Hughes, A. D., & Manisty, C. H. (2020). Training for a First-Time Marathon Reverses Age-Related Aortic Stiffening [Journal Article]. J Am Coll Cardiol, 75(1), 60–71. https://doi.org/10.1016/j.jacc.2019.10.045
  56. Bhuva, A. N., D’Silva, A., Torlasco, C., Nadarajan, N., Jones, S., Boubertakh, R., Van Zalen, J., Scully, P., Knott, K., Benedetti, G., Augusto, J. B., Bastiaenen, R., Lloyd, G., Sharma, S., Moon, J. C., Parker, K. H., Manisty, C. H., & Hughes, A. D. (2020). Non-invasive assessment of ventriculo-arterial coupling using aortic wave intensity analysis combining central blood pressure and phase-contrast cardiovascular magnetic resonance [Journal Article]. Eur Heart J Cardiovasc Imaging, 21(7), 805–813. https://doi.org/10.1093/ehjci/jez227
  57. Bhuva, A. N., Treibel, T. A., De Marvao, A., Biffi, C., Dawes, T. J. W., Doumou, G., Bai, W., Patel, K., Boubertakh, R., Rueckert, D., O’Regan, D. P., Hughes, A. D., Moon, J. C., & Manisty, C. H. (2020). Sex and regional differences in myocardial plasticity in aortic stenosis are revealed by 3D model machine learning [Journal Article]. Eur Heart J Cardiovasc Imaging, 21(4), 417–427. https://doi.org/10.1093/ehjci/jez166
  58. Bian, W., Ahmadi, M. N., Biswas, R. K., Blodgett, J. M., Atkin, A. J., Chan, H. W., Del Pozo Cruz, B., Suorsa, K., Bakker, E. A., Pulsford, R. M., Mielke, G. I., Johansson, P. J., Hettiarachchi, P., Koemel, N. A., Thijssen, D. H. J., Stenholm, S., Mishra, G. D., Teixeira-Pinto, A., Rangul, V., … Pro, P. C. (2025). Device-Measured Sleep Characteristics, Daily Step Count, and Cardiometabolic Health Markers: Findings From the Prospective Physical Activity, Sitting, and Sleep (ProPASS) Consortium [Journal Article]. Circ Cardiovasc Qual Outcomes, 18(8), e011873. https://doi.org/10.1161/CIRCOUTCOMES.124.011873
  59. Bicknell, C. D., Cowling, M. G., Clark, M. W., Delis, K. T., Jenkins, M. P., Hughes, A. D., Thom, S. A., Wolfe, J. H., & Cheshire, N. J. (2003). Carotid angioplasty in a pulsatile flow model: factors affecting embolic potential [Journal Article]. Eur J Vasc Endovasc Surg, 26(1), 22–31. http://www.ncbi.nlm.nih.gov/pubmed/12819644
  60. Birnie, K., Howe, L. D., Jones, T., Madley-Dowd, P., Martin, F. Z., Forbes, H., Redaniel, M. T., Cornish, R., Magnus, M. C., Davies, N. M., Tilling, K., Hughes, A. D., Lawlor, D. A., & Fraser, A. (2025). Life course trajectories of maternal cardiovascular disease risk factors by obstetric history: a UK cohort study using electronic health records [Journal Article]. BMC Med, 23(1), 91. https://doi.org/10.1186/s12916-025-03937-y
  61. Blodgett, J. M., Ahmadi, M. N., Atkin, A. J., Chastin, S., Chan, H. W., Suorsa, K., Bakker, E. A., Hettiarcachchi, P., Johansson, P. J., Sherar, L. B., Rangul, V., Pulsford, R. M., Mishra, G., Eijsvogels, T. M. H., Stenholm, S., Hughes, A. D., Teixeira-Pinto, A. M., Ekelund, U., Lee, I. M., … Pro, P. C. (2024). Device-measured physical activity and cardiometabolic health: the Prospective Physical Activity, Sitting, and Sleep (ProPASS) consortium [Journal Article]. Eur Heart J, 45(6), 458–471. https://doi.org/10.1093/eurheartj/ehad717
  62. Blodgett, J. M., Ahmadi, M. N., Atkin, A. J., Pulsford, R. M., Rangul, V., Chastin, S., Chan, H. W., Suorsa, K., Bakker, E. A., Gupta, N., Hettiarachchi, P., Johansson, P. J., Sherar, L. B., Del Pozo Cruz, B., Koemel, N. A., Mishra, G. D., Eijsvogels, T. M. H., Stenholm, S., Hughes, A. D., … Pro, P. C. (2025). Device-Measured 24-Hour Movement Behaviors and Blood Pressure: A 6-Part Compositional Individual Participant Data Analysis in the ProPASS Consortium [Journal Article]. Circulation, 151(2), 159–170. https://doi.org/10.1161/CIRCULATIONAHA.124.069820
  63. Borges, M. C., Schmidt, A. F., Jefferis, B., Wannamethee, S. G., Lawlor, D. A., Kivimaki, M., Kumari, M., Gaunt, T. R., Ben-Shlomo, Y., Tillin, T., Menon, U., Providencia, R., Dale, C., Gentry-Maharaj, A., Hughes, A., Chaturvedi, N., Casas, J. P., Hingorani, A. D., & Consortium**, U. (2020). Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta-Analysis in Up to 16 126 Participants [Journal Article]. J Am Heart Assoc, 9(5), e013131. https://doi.org/10.1161/JAHA.119.013131
  64. Brown, C. E., McCarthy, N. S., Hughes, A. D., Sever, P., Stalmach, A., Mullen, W., Dominiczak, A. F., Sattar, N., Mischak, H., Thom, S., Mayet, J., Stanton, A. V., & Delles, C. (2015). Urinary proteomic biomarkers to predict cardiovascular events [Journal Article]. Proteomics Clin Appl, 9(5-6), 610–617. https://doi.org/10.1002/prca.201400195
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  70. Bui, T. V., Picone, D. S., Schultz, M. G., Armstrong, M. K., Peng, X., Black, J. A., Dwyer, N., Roberts-Thomson, P., Adams, H., Hughes, A. D., & Sharman, J. E. (2022). Comparison between cuff-based and invasive systolic blood pressure amplification [Journal Article]. J Hypertens, 40(10), 2037–2044. https://doi.org/10.1097/HJH.0000000000003228
  71. Buus, N. H., Carlsen, R. K., Hughes, A. D., & Skov, K. (2020). Influence of Renal Transplantation and Living Kidney Donation on Large Artery Stiffness and Peripheral Vascular Resistance [Journal Article]. Am J Hypertens, 33(3), 234–242. https://doi.org/10.1093/ajh/hpz175
  72. Byrd-Raynor, S., Alastruey, J., Hughes, A., Thom, S., & Parker, K. H. (2008). The Relationship between Velocity and Cerebral Resistance during Vasomotor Reactivity Testing: Should We Report a Different Measurement? [Journal Article]. Journal for Vascular Ultrasound, 32(2), 67–74. https://doi.org/10.1177/154431670803200201
  73. Campbell, M. D., Laitinen, T. T., Hughes, A., Pahkala, K., Juonala, M., Kahonen, M., Wong, T. Y., Lehtimaki, T., Hutri-Kahonen, N., Raitakari, O. T., & Tapp, R. J. (2018). Impact of Ideal Cardiovascular Health in Childhood on the Retinal Microvasculature in Midadulthood: Cardiovascular Risk in Young Finns Study [Journal Article]. J Am Heart Assoc, 7(20), e009487. https://doi.org/10.1161/JAHA.118.009487
  74. Canfield, S. P., Hughes, A. D., Price, C. A., & Spencer, J. E. (1981). The action of beta-adrenoceptor agonists on acid secretion by the rat isolated stomach [Journal Article]. J Physiol, 316(JUL), 23–31. https://doi.org/10.1113/jphysiol.1981.sp013769
  75. Cap, M., Karaduman, M., Zhou, T., Erdogan, E., Tanboga, I. H., Tufaro, V., He, X., Bajaj, R., Yap, N. A. L., Khan, A. H., Koo, B. K., Rakhit, R., Karamasis, G. V., Abdulelah, Z. A., Hughes, A., Serruys, P. W., Mathur, A., Baumbach, A., Torii, R., … Bourantas, C. V. (2025). An Automated User-friendly Software for Fast Computation of Blood Flow Velocity From Coronary Angiographic Images [Journal Article]. Angiology, 33197251338474. https://doi.org/10.1177/00033197251338474
  76. Captur, G., Karperien, A. L., Hughes, A. D., Francis, D. P., & Moon, J. C. (2016). The fractal heart - embracing mathematics in the cardiology clinic [Journal Article]. Nat Rev Cardiol. https://doi.org/10.1038/nrcardio.2016.161
  77. Carter, A. R., Santos Ferreira, D. L., Taylor, A. E., Lawlor, D. A., Davey Smith, G., Sattar, N., Chaturvedi, N., Hughes, A. D., & Howe, L. D. (2020). Role of the Metabolic Profile in Mediating the Relationship Between Body Mass Index and Left Ventricular Mass in Adolescents: Analysis of a Prospective Cohort Study [Journal Article]. J Am Heart Assoc, 9(20), e016564. https://doi.org/10.1161/JAHA.120.016564
  78. Catchlove, S. J., Pipingas, A., Hughes, M. E., & Macpherson, H. (2018). Magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review [Journal Article]. BMC Neurosci, 19(1), 21. https://doi.org/10.1186/s12868-018-0421-4
  79. Catling, F. J. R., Parker, K. H., Hughes, A. D., Harris, S., & Gordon, A. C. (2024). Towards personalised treatment in septic shock via Bayesian inversion of a one-dimensional vascular model [Journal Article]. Journal of Critical Care, 81. https://doi.org/10.1016/j.jcrc.2024.154555
  80. Cecelja, M., Keehn, L., Ye, L., Spector, T. D., Hughes, A. D., & Chowienczyk, P. (2020). Genetic aetiology of blood pressure relates to aortic stiffness with bi-directional causality: evidence from heritability, blood pressure polymorphisms, and Mendelian randomization [Journal Article]. Eur Heart J, 41(35), 3314–3322. https://doi.org/10.1093/eurheartj/ehaa238
  81. Chandrasekar, R., Lacey, R. E., Chaturvedi, N., Hughes, A. D., Patalay, P., & Khanolkar, A. R. (2023). Adverse childhood experiences and the development of multimorbidity across adulthood-a national 70-year cohort study [Journal Article]. Age Ageing, 52(4). https://doi.org/10.1093/ageing/afad062
  82. Chandrasekaran, A. M., Kinra, S., Ajay, V. S., Chattopadhyay, K., Singh, K., Singh, K., Praveen, P. A., Soni, D., Devarajan, R., Kondal, D., Manchanda, S. C., Hughes, A. D., Chaturvedi, N., Roberts, I., Pocock, S., Ebrahim, S., Reddy, K. S., Tandon, N., Prabhakaran, D., & Yoga-CaRe Trial, T. (2019). Effectiveness and cost-effectiveness of a Yoga-based Cardiac Rehabilitation (Yoga-CaRe) program following acute myocardial infarction: Study rationale and design of a multi-center randomized controlled trial [Journal Article]. Int J Cardiol, 280, 14–18. https://doi.org/10.1016/j.ijcard.2019.01.012
  83. Chapman, N., Dell’omo, G., Sartini, M. S., Witt, N., Hughes, A., Thom, S., & Pedrinelli, R. (2002). Peripheral vascular disease is associated with abnormal arteriolar diameter relationships at bifurcations in the human retina [Journal Article]. Clin Sci (Lond), 103(2), 111–116. https://doi.org/10.1042/
  84. Chapman, N., Haimes, G., Stanton, A. V., Thom, S. A., & Hughes, A. D. (2000). Acute effects of oxygen and carbon dioxide on retinal vascular network geometry in hypertensive and normotensive subjects [Journal Article]. Clin Sci (Lond), 99(6), 483–488. http://www.ncbi.nlm.nih.gov/pubmed/11099390
  85. Chapman, N., Mohamudally, A., Cerutti, A., Stanton, A., Sayer, A. A., Cooper, C., Barker, D., Rauf, A., Evans, J., Wormald, R., Sever, P., Hughes, A., & Thom, S. (1997). Retinal vascular network architecture in low-birth-weight men [Journal Article]. J Hypertens, 15(12 Pt 1), 1449–1453. https://doi.org/10.1097/00004872-199715120-00012
  86. Chapman, N., Witt, N., Gao, X., Bharath, A. A., Stanton, A. V., Thom, S. A., & Hughes, A. D. (2001). Computer algorithms for the automated measurement of retinal arteriolar diameters [Journal Article]. Br J Ophthalmol, 85(1), 74–79. https://doi.org/10.1136/bjo.85.1.74
  87. Charakida, M., Georgiopoulos, G., Dangardt, F., Chiesa, S. T., Hughes, A. D., Rapala, A., Davey Smith, G., Lawlor, D., Finer, N., & Deanfield, J. E. (2019). Early vascular damage from smoking and alcohol in teenage years: the ALSPAC study [Journal Article]. Eur Heart J, 40(4), 345–353. https://doi.org/10.1093/eurheartj/ehy524
  88. Charakida, M., Georgiopoulos, G., Dangardt, F., Chiesa, S. T., Hughes, A. D., Rapala, A., Davey Smith, G., Lawlor, D., Finer, N., & Deanfield, J. E. (2019). Response to ’Does smoking or alcohol cause early vascular damage in teenage years?’ [Journal Article]. Eur Heart J, 40(42), 3497. https://doi.org/10.1093/eurheartj/ehz608
  89. Charalambous, C., Moon, J. C., Holly, J. M. P., Chaturvedi, N., Hughes, A. D., & Captur, G. (2022). Declining Levels and Bioavailability of IGF-I in Cardiovascular Aging Associate With QT Prolongation-Results From the 1946 British Birth Cohort [Journal Article]. Front Cardiovasc Med, 9, 863988. https://doi.org/10.3389/fcvm.2022.863988
  90. Chattopadhyay, K., Chandrasekaran, A. M., Praveen, P. A., Manchanda, S. C., Madan, K., Ajay, V. S., Singh, K., Tillin, T., Hughes, A. D., Chaturvedi, N., Ebrahim, S., Pocock, S., Reddy, K. S., Tandon, N., Prabhakaran, D., & Kinra, S. (2019). Development of a Yoga-Based Cardiac Rehabilitation (Yoga-CaRe) Programme for Secondary Prevention of Myocardial Infarction [Journal Article]. Evid Based Complement Alternat Med, 2019, 7470184. https://doi.org/10.1155/2019/7470184
  91. Chaturvedi, N., Bathula, R., Shore, A. C., Panerai, R., Potter, J., Kooner, J., Chambers, J., & Hughes, A. D. (2012). South Asians have elevated postexercise blood pressure and myocardial oxygen consumption compared to Europeans despite equivalent resting pressure [Journal Article]. J Am Heart Assoc, 1(5), e000281. https://doi.org/10.1161/JAHA.111.000281
  92. Chaturvedi, N., Coady, E., Mayet, J., Wright, A. R., Shore, A. C., Byrd, S., Mc, G. T. S. A., Kooner, J. S., Schalkwijk, C. G., & Hughes, A. D. (2007). Indian Asian men have less peripheral arterial disease than European men for equivalent levels of coronary disease [Journal Article]. Atherosclerosis, 193(1), 204–212. https://doi.org/10.1016/j.atherosclerosis.2006.06.017
  93. Chaturvedi, N., Coady, E., Mayet, J., Wright, A. R., Shore, A. C., Thom, S. A. M. C. G., Kooner, J., & Hughes, A. D. (2006). Femoral atherosclerosis is reduced in South Asian compared with European men [Journal Article]. Atherosclerosis Supplements, 7(3), 104. https://doi.org/10.1016/S1567-5688(06)80395-8
  94. Chiesa, S. T., Charakida, M., Georgiopoulos, G., Dangardt, F., Wade, K. H., Rapala, A., Bhowruth, D. J., Nguyen, H. C., Muthurangu, V., Shroff, R., Davey Smith, G., Lawlor, D. A., Sattar, N., Timpson, N. J., Hughes, A. D., & Deanfield, J. E. (2021). Determinants of Intima-Media Thickness in the Young: The ALSPAC Study [Journal Article]. JACC Cardiovasc Imaging, 14(2), 468–478. https://doi.org/10.1016/j.jcmg.2019.08.026
  95. Chiesa, S. T., Charakida, M., Georgiopoulos, G., Roberts, J. D., Stafford, S. J., Park, C., Mykkanen, J., Kahonen, M., Lehtimaki, T., Ala-Korpela, M., Raitakari, O., Pietiainen, M., Pussinen, P., Muthurangu, V., Hughes, A. D., Sattar, N., Timpson, N. J., & Deanfield, J. E. (2022). Glycoprotein Acetyls: A Novel Inflammatory Biomarker of Early Cardiovascular Risk in the Young [Journal Article]. J Am Heart Assoc, 11(4), e024380. https://doi.org/10.1161/JAHA.121.024380
  96. Chiesa, S. T., Masi, S., Shipley, M. J., Ellins, E. A., Fraser, A. G., Hughes, A. D., Patel, R. S., Khir, A. W., Halcox, J. P., Singh-Manoux, A., Kivimaki, M., Celermajer, D. S., & Deanfield, J. E. (2019). Carotid artery wave intensity in mid- to late-life predicts cognitive decline: the Whitehall II study [Journal Article]. Eur Heart J, 40(28), 2300–2309. https://doi.org/10.1093/eurheartj/ehz189
  97. Chiesa, S. T., Norris, T., Garfield, V., Richards, M., & Hughes, A. D. (2024). Early-life cumulative exposure to excess bodyweight and midlife cognitive function: longitudinal analysis in three British birth cohorts [Journal Article]. Lancet Healthy Longev, 5(3), e204–e213. https://doi.org/10.1016/S2666-7568(24)00005-9
  98. Chiesa, S. T., Rader, L., Garfield, V., Foote, I., Suri, S., Davey Smith, G., Hughes, A. D., & Richardson, T. G. (2025). Childhood adiposity underlies numerous adult brain traits commonly attributed to midlife obesity [Journal Article]. Brain, 148(1), 133–142. https://doi.org/10.1093/brain/awae198
  99. Chirinos, J. A., Segers, P., Hughes, T., & Townsend, R. (2019). Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review [Journal Article]. J Am Coll Cardiol, 74(9), 1237–1263. https://doi.org/10.1016/j.jacc.2019.07.012
  100. Christie, I. N., Windsor, R., Mutsaerts, H. J., Tillin, T., Sudre, C. H., Hughes, A. D., Golay, X., Gourine, A. V., & Hosford, P. S. (2022). Cerebral perfusion in untreated, controlled, and uncontrolled hypertension [Journal Article]. J Cereb Blood Flow Metab, 42(12), 2188–2190. https://doi.org/10.1177/0271678X221124644
  101. Christofi, F., Wijetunge, S., Sever, P. S., & Hughes, A. D. (2010). Expression and function of the tissue renin-angiotensin system in human vascular smooth muscle cells in culture [Journal Article]. Cardiovascular Research, 87, S60. https://watermark.silverchair.com/cvq029.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAccwggHDBgkqhkiG9w0BBwagggG0MIIBsAIBADCCAakGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM60_Lhko_BpF9piumAgEQgIIBerfa4FxW9Wq-Psmv6jWu6ot3DnVylpo9OVLon8a9mdh_ik1AAUbXeJThiZpFBIIWU8dIq0wQymNrJBhIDz8dvgMk6sRViETsZ9l2A5kG_sgPfOi_8HZ2RNQF-O2vxgeG_5Z4xDp0lEO8FMScAucRvlczgLmZVXJz-wCYnSAe3W7JvoIFNpw58cEiaTII5rfFkpAR4z8X94qZcZ-KPK0GEUTJfjYbeUwZI65oQWosoAnIpYRfr1qqqqxVjirUQmYa5QM3tjCYvCFPMG8dWmtV3pnp-dTLZ1wJm667igeNC0AOMxU2WXGQDVdHgAhY8i8RGzXbfnIPXYkcSODW4VfIoNfVWsKlTp8Ks2lsfT9h1iPpXByNethk8p2QI8bs68GFcXUxfU1HIMrt1h6rJOiQzOI4Q6NIjBqLto2YTborQVhTnHBxaHX65l1E1R2zlwf6nuD9Wn7Cc75qOG_eSJe8w4iK5yIGXvFY0eboaOCREWu0bPyiFvxqwRFtZQ
  102. Clarke, S. L. N., Jones, H. J., Sharp, G. C., Easey, K. E., Hughes, A. D., Ramanan, A. V., & Relton, C. L. (2022). Juvenile idiopathic arthritis polygenic risk scores are associated with cardiovascular phenotypes in early adulthood: a phenome-wide association study [Journal Article]. Pediatr Rheumatol Online J, 20(1), 105. https://doi.org/10.1186/s12969-022-00760-0
  103. Clunn, G., Hughes, A., & Schachter, M. (2000). Endotoxin-lipoprotein hypothesis. [Journal Article]. Lancet, 356(9247), 2097–2098. https://doi.org/10.1016/S0140-6736(05)74306-3
  104. Clunn, G. F., Lymn, J. S., Schachter, M., & Hughes, A. D. (1997). Differential effects of lovastatin on mitogen induced calcium influx in human cultured vascular smooth muscle cells [Journal Article]. Br J Pharmacol, 121(8), 1789–1795. https://doi.org/10.1038/sj.bjp.0701299
  105. Clunn, G. F., Refson, J. S., Lymn, J. S., & Hughes, A. D. (1997). Platelet-derived growth factor beta-receptors can both promote and inhibit chemotaxis in human vascular smooth muscle cells [Journal Article]. Arterioscler Thromb Vasc Biol, 17(11), 2622–2629. https://doi.org/10.1161/01.ATV.17.11.2622
  106. Clunn, G. F., Refson, J. S., Schachter, M., & Hughes, A. D. (1995). Different effects of platelet derived growth factor isoforms on DNA synthesis and migration in human vascular smooth muscle cells [Journal Article]. Biochem Soc Trans, 23(4), 608S. http://www.ncbi.nlm.nih.gov/pubmed/8654793
  107. Clunn, G. F., Schachter, M., & Hughes, A. D. (1995). Contrasting mechanisms of intracellular calcium ([Ca2+]i) elevation by angiotensin II (AII) and platelet derived growth factor-BB (PDGF-BB) in human vascular smooth muscle cells (VSMCs) [Journal Article]. Biochem Soc Trans, 23(2), 170S. https://doi.org/10.1042/bst023170s
  108. Clunn, G. F., Sever, P. S., & Hughes, A. D. (2010). Calcium channel regulation in vascular smooth muscle cells: Synergistic effects of statins and calcium channel blockers [Journal Article]. Int J Cardiol, 139(1), 2–6. https://doi.org/10.1016/j.ijcard.2009.05.019
  109. Clunn, G. F., Wijetunge, S., & Hughes, A. D. (1999). Effect of hypercholesterolaemia on voltage-operated calcium channel currents in rabbit arterial smooth muscle cells [Journal Article]. J Hum Hypertens, 13(12), 849–853. https://doi.org/10.1038/sj.jhh.1000898
  110. Comella, A., Michail, M., Chan, J., Cameron, J. D., Gooley, R., Mathur, A., Hughes, A. D., & Brown, A. J. (2021). Patients with aortic stenosis exhibit early improved endothelial function following transcatheter aortic valve replacement: The eFAST study [Journal Article]. Int J Cardiol, 332, 143–147. https://doi.org/10.1016/j.ijcard.2021.03.062
  111. Coombes, J. E., Hughes, A. D., & Thom, S. A. (1999). Intravascular pressure-evoked changes in intracellular calcium [Ca2+], and tone in rat mesenteric and rabbit cerebral arteries in vitro [Journal Article]. Journal of Human Hypertension, 13(12), 855–858. https://doi.org/10.1038/sj.jhh.1000902
  112. Coombes, J. E., Hughes, A. D., & Thom, S. A. (1999). Intravascular pressure-evoked changes in intracellular calcium [Ca2+]i and tone in rat mesenteric and rabbit cerebral arteries in vitro [Journal Article]. J Hum Hypertens, 13(12), 855–858. https://doi.org/10.1038/sj.jhh.1000902
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  114. Corden, B., Keenan, N. G., de Marvao, A. S., Dawes, T. J., Decesare, A., Diamond, T., Durighel, G., Hughes, A. D., Cook, S. A., & O’Regan, D. P. (2013). Body fat is associated with reduced aortic stiffness until middle age [Journal Article]. Hypertension, 61(6), 1322–1327. https://doi.org/10.1161/HYPERTENSIONAHA.113.01177
  115. Cross, S. S., Hughes, A. D., Williams, G. T., & Williams, E. D. (1988). Endocrine cell hyperplasia and appendiceal carcinoids [Journal Article]. J Pathol, 156(4), 325–329. https://doi.org/10.1002/path.1711560409
  116. Crowe, L. A., Ariff, B., Keegan, J., Mohiaddin, R. H., Yang, G. Z., Hughes, A. D., Mc, G. T. S. A., & Firmin, D. N. (2005). Comparison between three-dimensional volume-selective turbo spin-echo imaging and two-dimensional ultrasound for assessing carotid artery structure and function [Journal Article]. J Magn Reson Imaging, 21(3), 282–289. https://doi.org/10.1002/jmri.20257
  117. Cunningham, S. L., Mayet, J., Parker, K. H., Foale, R. A., Thom, S. A. M., & Hughes, A. D. (2003). Wave intensity analysis: Insights in haemodynamic abnormalities in heart failure [Journal Article]. Heart, 89, 37–37. ://WOS:000186265800008</span></li>
  118. Cunningham, S. L., Parker, K. H., Mayet, J., Foale, R. A., Thom, S. A. M., & Hughes, A. D. (2004). Peripheral haemodynamics are altered in diastolic heart failure [Journal Article]. Heart, 90, 32–32. ://WOS:000225386600012</span></li>
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  174. Fonseca, R., Palmer, A. J., Picone, D. S., Cox, I. A., Schultz, M. G., Black, J. A., Bos, W. J. W., Cheng, H. M., Chen, C. H., Cremer, A., Dwyer, N., Hughes, A. D., Lacy, P., Omboni, S., Ott, C., Pereira, T., Pucci, G., Schmieder, R., Wang, J. G., … Sharman, J. E. (2023). Cardiovascular and health cost impacts of cuff blood pressure underestimation and overestimation of invasive aortic systolic blood pressure [Journal Article]. J Hypertens. https://doi.org/10.1097/HJH.0000000000003510
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  176. Gao, X. H., Bharath, A. A., Hughes, A., Stanton, A., Chapman, N., Thom, S., & Hansen, K. M. (1997). Towards retinal vessel parameterisation [Book Section]. In Image Processing - Medical Imaging 1997, Pts 1 and 2 (Vol. 3034, pp. 734–744). https://doi.org/10.1117/12.274160
  177. Gao, X. H., Bharath, A., Stanton, A., Hughes, A., Chapman, N., & Thom, S. (2001). A method of vessel tracking for vessel diameter measurement on retinal images [Journal Article]. Proceedings of the 2001 International Conference on Image Processing, II, 881–884. https://doi.org/10.1109/ICIP.2001.958635
  178. Gao, X. W., Bharath, A., Stanton, A., Hughes, A., Chapman, N., & Thom, S. (2000). Quantification and characterisation of arteries in retinal images [Journal Article]. Comput Meth Prog Bio, 63(2), 133–146. http://www.ncbi.nlm.nih.gov/pubmed/10960746
  179. Garcha, R., Schachter, M., Hughes, A., Thom, S. M., & Sever, P. (1991). Amlodipine inhibition of alpha-agonist induced contraction in human resistance vessels [Journal Article]. J Hypertens Suppl, 9(6), S368–9. http://www.ncbi.nlm.nih.gov/pubmed/1687875
  180. Garcha, R. S., & Hughes, A. D. (1994). Action of heparin and ruthenium red on responses of reversibly-permeabilised rat mesenteric arteries [Journal Article]. Eur J Pharmacol, 268(3), 319–325. http://www.ncbi.nlm.nih.gov/pubmed/7528678
  181. Garcha, R. S., & Hughes, A. D. (1994). Action of Heparin and Ruthenium Red on Responses of Reversibly-Permeabilized Rat Mesenteric-Arteries [Journal Article]. European Journal of Pharmacology-Molecular Pharmacology Section, 268(3), 319–325. https://doi.org/Doi 10.1016/0922-4106(94)90056-6
  182. Garcha, R. S., & Hughes, A. D. (1995). Inhibition of norepinephrine and caffeine-induced activation by ryanodine and thapsigargin in rat mesenteric arteries [Journal Article]. J Cardiovasc Pharmacol, 25(5), 840–846. http://www.ncbi.nlm.nih.gov/pubmed/7630163
  183. Garcha, R. S., & Hughes, A. D. (1997). Action of ryanodine on neurogenic responses in rat isolated mesenteric small arteries [Journal Article]. Br J Pharmacol, 122(1), 142–148. https://doi.org/10.1038/sj.bjp.0701337
  184. Garcha, R. S., & Hughes, A. D. (2006). CNP, but not ANP or BNP, relax human isolated subcutaneous resistance arteries by an action involving cyclic GMP and BKCa channels [Journal Article]. J Renin Angiotensin Aldosterone Syst, 7(2), 87–91. https://doi.org/10.3317/jraas.2006.014
  185. Garcha, R. S., Sever, P. S., & Hughes, A. D. (1993). The action of amlodipine on human subcutaneous resistance arteries studied in vitro [Journal Article]. J Pharmacol Exp Ther, 265(2), 860–865. https://www.ncbi.nlm.nih.gov/pubmed/8496831
  186. Garcha, R. S., Sever, P. S., & Hughes, A. D. (1999). Action of AT1 receptor antagonists on angiotensin II-induced tone in human isolated subcutaneous resistance arteries [Journal Article]. Br J Pharmacol, 127(8), 1876–1882. https://doi.org/10.1038/sj.bjp.0702722
  187. Garcha, R. S., Sever, P. S., & Hughes, A. D. (2001). Mechanism of action of angiotensin II in human isolated subcutaneous resistance arteries [Journal Article]. Br J Pharmacol, 134(1), 188–196. https://doi.org/10.1038/sj.bjp.0704222
  188. Ghosh, A. K., Francis, D. P., Chaturvedi, N., Kuh, D., Mayet, J., Hughes, A. D., & Hardy, R. J. (2014). Cardiovascular Risk Factors from Early Life Predict Future Adult Cardiac Structural and Functional Abnormalities: A Systematic Review of the Published Literature [Journal Article]. J Cardiol Ther, 2(2), 78–87. https://doi.org/10.12970/2311-052X.2014.02.02.4
  189. Ghosh, A. K., Hardy, R., Francis, D., Chaturvedi, N., Deanfield, J., Pellerin, D., Pierce, M., Kuh, D., Mayet, J., & Hughes, A. (2012). Duration of Diabetes Is a Significant Independent Predictor of Elevated Left Ventricular Mass [Journal Article]. Journal of the American College of Cardiology, 59(13), E1727–E1727. https://doi.org/10.1016/S0735-1097(12)61728-8
  190. Ghosh, A. K., Hardy, R. J., Francis, D. P., Chaturvedi, N., Pellerin, D., Deanfield, J., Kuh, D., Mayet, J., & Hughes, A. D. (2012). 137 Time for a review of the “watch and wait” strategy for young borderline-hypertensives? [Journal Article]. Heart, 98(Suppl 1), A77.2–A77. https://doi.org/10.1136/heartjnl-2012-301877b.137
  191. Ghosh, A. K., Hardy, R. J., Francis, D. P., Chaturvedi, N., Pellerin, D., Deanfield, J., Kuh, D., Mayet, J., & Hughes, A. D. (2012). Is it time for a new look at the ’watch and wait’ approach-mid-life antihypertensive treatment may not normalize left ventricular mass in spite of controlled blood pressure [Journal Article]. Journal of Human Hypertension, 26(10), 616. https://www.nature.com/articles/jhh201232.pdf
  192. Ghosh, A. K., Hardy, R. J., Francis, D. P., Chaturvedi, N., Pellerin, D., Deanfield, J., Kuh, D., Mayet, J., & Hughes, A. D. (2012). Time for a review of the "watch and wait" strategy for young borderline-hypertensives? [Journal Article]. Heart, 98, A77. https://doi.org/10.1136/heartjnl-2012-301877b.137
  193. Ghosh, A. K., Hardy, R. J., Francis, D. P., Chaturvedi, N., Pellerin, D., Deanfield, J., Kuh, D., Mayet, J., & Hughes, A. D. (2014). Midlife blood pressure change and left ventricular mass and remodelling in older age in the 1946 British Birth Cohort Study [Journal Article]. Eur Heart J, 35(46), 3287–3295. https://doi.org/10.1093/eurheartj/ehu389
  194. Ghosh, A. K., Hughes, A., Chaturvedi, N., Francis, D., Kuh, D., Deanfield, J., Pellerin, D., Mayet, J., & Hardy, R. (2013). Adult Life Course Body Mass Index and Age at First Detection of Overweight Are Associated with Future Increases in Left Ventricular Mass Index [Journal Article]. Journal of the American College of Cardiology, 61(10), E1344–E1344. https://doi.org/10.1016/S0735-1097(13)61344-3
  195. Ghosh, A. K., Hughes, A., Francis, D., Chaturvedi, N., Pellerin, D., Deanfield, J., Kuh, D., Mayet, J., & Hardy, R. (2012). Mid-Life Anti-Hypertensive Treatment May Not Normalize Left Ventricular Mass in Spite of Controlled Blood Pressure [Journal Article]. Journal of the American College of Cardiology, 59(13), E1722. https://doi.org/10.1016/s0735-1097(12)61723-9
  196. Ghosh, A. K., Hughes, A. D., Chaturvedi, N., Francis, D. P., Pellerin, D., Deanfield, J., Pierce, M., Kuh, D., Mayet, J., & Hardy, R. J. (2012). Increase in Left Ventricular Mass in Type 2 Diabetes Is Dependent on Duration of Diabetes [Journal Article]. Heart, 98, A77–A77. https://doi.org/10.1136/heartjnl-2012-301877b.136
  197. Ghosh, A. K., Hughes, A. D., Francis, D., Chaturvedi, N., Pellerin, D., Deanfield, J., Kuh, D., Mayet, J., & Hardy, R. (2016). Midlife blood pressure predicts future diastolic dysfunction independently of blood pressure [Journal Article]. Heart, 102(17), 1380–1387. https://doi.org/10.1136/heartjnl-2015-308836
  198. Giannoni, A., Baruah, R., Willson, K., Mebrate, Y., Mayet, J., Emdin, M., Hughes, A. D., Manisty, C. H., & Francis, D. P. (2010). Real-time dynamic carbon dioxide administration: a novel treatment strategy for stabilization of periodic breathing with potential application to central sleep apnea [Journal Article]. J Am Coll Cardiol, 56(22), 1832–1837. https://doi.org/10.1016/j.jacc.2010.05.053
  199. Giudici, A., Palombo, C., Kozakova, M., Morizzo, C., Losso, L., Nannipieri, M., Berta, R., Hughes, A. D., Cruickshank, J. K., & Khir, A. W. (2020). Weight Loss After Bariatric Surgery Significantly Improves Carotid and Cardiac Function in Apparently Healthy People with Morbid Obesity [Journal Article]. Obes Surg, 30(10), 3776–3783. https://doi.org/10.1007/s11695-020-04686-y
  200. Glor, F. P., Ariff, B., Hughes, A. D., Crowe, L. A., Verdonck, P. R., Barratt, D. C., Thom, S. A. M. G., Firmin, D. N., & Xu, X. Y. (2004). The integration of medical imaging and computational fluid dynamics for measuring wall shear stress in carotid arteries [Book Section]. In Proceedings of the 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-7 (Vol. 26, pp. 1415–1418).
  201. Glor, F., Ariff, B., Xu, X. Y., Augst, A. D., Hughes, A. D., McG Thom, S. A., Byrd, S., Barratt, D. C., & Verdonck, P. (2003). Hemodynamic impact of head rotation on carotids [Journal Article]. Archives of Physiology and Biochemistry, 111(1), 87. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141618493&partnerID=MN8TOARS
  202. Glor, F. P., Ariff, B., Augst, A. D., Barratt, D. C., Hughes, A. D., Thom, S. A. M., Verdonck, P., & Xu, X. Y. (2003). 3D ultrasound-based CFD for carotid flow prediction: a reproducibility study [Journal Article]. Computational Fluid and Solid Mechanics 2003, Vols 1 and 2, Proceedings, 1701–1704. ://WOS:000184938200411</span></li>
  203. Glor, F. P., Ariff, B., Crowe, L. A., Hughes, A. D., Cheong, P. L., Thom, S. A. M., Verdonck, P. R., Firmin, D. N., Barratt, D. C., & Xu, X. Y. (2003). Carotid geometry reconstruction: a comparison between MRI and ultrasound [Journal Article]. Med Phys, 30(12), 3251–3261. https://doi.org/Doi 10.1118/1.1628412
  204. Glor, F. P., Ariff, B., Hughes, A. D., Crowe, L. A., Verdonck, P. R., Barratt, D. C., Thom, S. A. M. G., Firmin, D. N., & Xu, X. Y. (2004). Image-based carotid flow reconstruction: a comparison between MRI and ultrasound [Journal Article]. Physiol Meas, 25(6), 1495–1509. https://doi.org/10.1088/0967-3334/25/6/014
  205. Glor, F. P., Ariff, B., Hughes, A. D., Crowe, L. A., Verdonck, P. R., Thom, S. A. M. G., Firmin, D. N., & Xu, X. Y. (2004). The effect of anti-hypertensive drugs on carotid haemodynamics [Conference Paper].
  206. Glor, F. P., Ariff, B., Hughes, A. D., Verdonck, P. R., Barratt, D. C., Augst, A. D., Thom, S. A., & Xu, X. Y. (2004). Influence of head position on carotid hemodynamics in young adults. [Journal Article]. Am J Physiol Heart Circ Physiol, 287(4), H1670–81. https://doi.org/10.1152/ajpheart.01186.2003
  207. Glor, F. P., Ariff, B., Hughes, A. D., Verdonck, P. R., Thom, S. A., Barratt, D. C., & Xu, X. Y. (2005). Operator dependence of 3-D ultrasound-based computational fluid dynamics for the carotid bifurcation [Journal Article]. IEEE Trans Med Imaging, 24(4), 451–456. https://doi.org/10.1109/TMI.2005.844173
  208. Glor, F. P., Long, Q., Hughes, A. D., Augst, A. D., Ariff, B., Thom, S. A., Verdonck, P. R., & Xu, X. Y. (2003). Reproducibility study of magnetic resonance image-based computational fluid dynamics prediction of carotid bifurcation flow [Journal Article]. Ann Biomed Eng, 31(2), 142–151. https://doi.org/10.1114/1.1537694
  209. Gonzalez-Martin, P., Webber, M., Chan, F., De, S., Topriceanu, C. C., Falconer, D., Zingaro, A., Pozo, J. M., Butakoff, C., Rudy, Y., Hughes, A. D., Orini, M., Vazquez, M., Aguado-Sierra, J., & Captur, G. (2024). A pipeline for developing digital cardiac twins integrating cardiovascular magnetic resonance and electrocardiographic imaging: results from the MyoFit46 study [Journal Article]. European Heart Journal, 45(Supplement_1). https://doi.org/ARTN ehae6663508 10.1093/eurheartj/ehae666.3508
  210. Gordillo-Maranon, M., Zwierzyna, M., Charoen, P., Drenos, F., Chopade, S., Shah, T., Engmann, J., Chaturvedi, N., Papacosta, O., Wannamethee, G., Wong, A., Sofat, R., Kivimaki, M., Price, J. F., Hughes, A. D., Gaunt, T. R., Lawlor, D. A., Gaulton, A., Hingorani, A. D., … Finan, C. (2021). Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics [Journal Article]. Nat Commun, 12(1), 6120. https://doi.org/10.1038/s41467-021-25731-z
  211. Goudswaard, L. J., Harrison, S., Van De Klee, D., Chaturvedi, N., Lawlor, D. A., Davey Smith, G., Hughes, A. D., & Howe, L. D. (2021). Blood pressure variability and night-time dipping assessed by 24-hour ambulatory monitoring: Cross-sectional association with cardiac structure in adolescents [Journal Article]. PLoS One, 16(6), e0253196. https://doi.org/10.1371/journal.pone.0253196
  212. Granell, R., Haider, S., Deliu, M., Ullah, A., Mahmoud, O., Fontanella, S., Lowe, L., Simpson, A., Dodd, J. W., Arshad, S. H., Murray, C. S., Roberts, G., Hughes, A., Park, C., Holloway, J. W., Custovic, A., & investigators, S. U. (2024). Lung function trajectories from school age to adulthood and their relationship with markers of cardiovascular disease risk [Journal Article]. Thorax, 79(8), 770–777. https://doi.org/10.1136/thorax-2023-220485
  213. Green, M. J., Maddock, J., Di Gessa, G., Wielgoszewska, B., Parsons, S., Griffith, G. J., Croft, J., Stevenson, A. J., Huggins, C. F., Booth, C., Wels, J., Silverwood, R. J., Patalay, P., Hughes, A. D., Chaturvedi, N., Howe, L. D., Fitzsimons, E., Katikireddi, S. V., & Ploubidis, G. B. (2022). The UK Coronavirus Job Retention Scheme and smoking, alcohol consumption and vaping during the COVID-19 pandemic: evidence from eight longitudinal population surveys [Journal Article]. BMC Med, 20(1), 345. https://doi.org/10.1186/s12916-022-02511-0
  214. Green, R. E., Sudre, C. H., Warren-Gash, C., Butt, J., Waterboer, T., Hughes, A. D., Schott, J. M., Richards, M., Chaturvedi, N., & Williams, D. M. (2024). Common infections and neuroimaging markers of dementia in three UK cohort studies [Journal Article]. Alzheimers Dement, 20(3), 2128–2142. https://doi.org/10.1002/alz.13613
  215. Gu, B., Huang, Y., Manchester, E. L., Hughes, A. D., Thom, S. A. M., Chen, R., & Xu, X. Y. (2022). Multiphysics Modelling and Simulation of Thrombolysis via Activated Platelet-Targeted Nanomedicine [Journal Article]. Pharm Res, 39(1), 41–56. https://doi.org/10.1007/s11095-021-03161-2
  216. Gu, B., Piebalgs, A., Huang, Y., Longstaff, C., Hughes, A. D., Chen, R., Thom, S. A., & Xu, X. Y. (2019). Mathematical Modelling of Intravenous Thrombolysis in Acute Ischaemic stroke: Effects of Dose Regimens on Levels of Fibrinolytic Proteins and Clot Lysis Time [Journal Article]. Pharmaceutics, 11(3). https://doi.org/10.3390/pharmaceutics11030111
  217. Gu, B., Piebalgs, A., Huang, Y., Roi, D., Lobotesis, K., Longstaff, C., Hughes, A. D., Chen, R., Thom, S. A., & Xu, X. Y. (2019). Computational simulations of thrombolysis in acute stroke: Effect of clot size and location on recanalisation [Journal Article]. Med Eng Phys, 73, 9–17. https://doi.org/10.1016/j.medengphy.2019.07.014
  218. Hadjiloiozu, N., Davies, J., Baksi, A. J., Baruah, R., Malik, I., Foale, R., Parker, K., Hughes, A., Francis, D., & Mayet, J. (2008). The importance of the microvasculature in determining the shape of the left and right coronary artery flow velocity waveform [Journal Article]. Heart, 94, A123–A124. http://heart.bmj.com/content/heartjnl/94/12/1545.full.pdf
  219. Hadjiloizou, N., Davies, J., Baksi, J., Malik, I., Hughes, A., Foale, R., Parker, K., Francis, D., & Mayet, J. (2010). Differential Effects of Hypertrophy Secondary to Hypertension and Aortic Stenosis on Coronary Haemodynamics [Journal Article]. Heart, 96, A58–A59. https://doi.org/10.1136/hrt.2010.196071.20
  220. Hadjiloizou, N., Davies, J. E., Malik, I. S., Aguado-Sierra, J., Willson, K., Foale, R. A., Parker, K. H., Hughes, A. D., Francis, D. P., & Mayet, J. (2008). Differences in cardiac microcirculatory wave patterns between the proximal left mainstem and proximal right coronary artery [Journal Article]. Am J Physiol Heart Circ Physiol, 295(3), H1198–H1205. https://doi.org/10.1152/ajpheart.00510.2008
  221. Hadjiloizou, N., Davies, J. E., Manisty, C. H., Whinnett, Z. I., Francis, D. P., Willson, K., Malik, I. S., Hughes, A. D., Parker, K. H., & Mayet, J. (2007). Physiological mechansims underlying the differences in flow velocity in the left and right coronary arteries [Journal Article]. European Heart Journal, 28, 753. https://watermark.silverchair.com/ehm272.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAckwggHFBgkqhkiG9w0BBwagggG2MIIBsgIBADCCAasGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMZwrWkOffWgKTH-U-AgEQgIIBfPhYcZkldO7awkx0KqRDo_-1lIjkpsyXyeLragyhCbcIrBWMX0hSQV04B_qTFC95kkJAos4eyBb0rq-WQ9uPdlvVE9aoeADxkFBZpbLUN8U3yNUREjhsLWc19PcEPf_JirUByGFq-5GYqmX4mwdvYLRzBeIpfaFB_a3IvCJSyXJILvWC7q-43_BA9peOPlkMZCt4ndglUbvyvuCzfODyfROxQc4lBAJoD_DFZu79bWo2G4KdGepYKhGlmmNQg95F-0Fxa6jhhxQ9C160WR4v0Jul6EOvdGUO7aBbD2IqRTuEwRG30ckC9Dvc_W4TrVlO7CNlLM9o_bzkyRWfbLAWvWdSrvX1gkGNoCj9Wtm4nhSyZkUopHV8BBPItZeklgHYb50aMJlidW1UA8vAUm-LzSh3yQatuJ4OezDMj-L27iOqAG02f6upsF2UaXcaDJ1dZbI7Ik8NUMjhzROcoSDh73Hg9sVQMuhT0LBjpol7TNqAcYlmUgrxKfSPde5L
  222. Hametner, B., Wassertheurer, S., Hughes, A. D., Parker, K. H., Weber, T., & Eber, B. (2014). Reservoir and excess pressures predict cardiovascular events in high-risk patients [Journal Article]. Int J Cardiol, 171(1), 31–36. https://doi.org/10.1016/j.ijcard.2013.11.039
  223. Hardy, R., Maddock, J., Ghosh, A., Deanfield, J., Hughes, A., & Kuh, D. (2017). Pubertal Timing and Cardiovascular Ageing in Men and Women [Journal Article]. Innovation in Aging, 1(suppl_1), 1282–1282. https://doi.org/10.1093/geroni/igx004.4681
  224. Hardy, R., Maddock, J., Ghosh, A. K., Hughes, A. D., & Kuh, D. (2019). The relationship between pubertal timing and markers of vascular and cardiac structure and function in men and women aged 60-64 years [Journal Article]. Sci Rep, 9(1), 11037. https://doi.org/10.1038/s41598-019-47164-x
  225. Hedegaard, E. R., Nielsen, B. D., Kun, A., Hughes, A. D., Kroigaard, C., Mogensen, S., Matchkov, V. V., Frobert, O., & Simonsen, U. (2014). KV 7 channels are involved in hypoxia-induced vasodilatation of porcine coronary arteries [Journal Article]. Br J Pharmacol, 171(1), 69–82. https://doi.org/10.1111/bph.12424
  226. Hendrick, E., Jamieson, A., Chiesa, S. T., Hughes, A. D., & Jones, S. (2024). A short review of application of near-infrared spectroscopy (NIRS) for the assessment of microvascular post-occlusive reactive hyperaemia (PORH) in skeletal muscle [Journal Article]. Front Physiol, 15, 1480720. https://doi.org/10.3389/fphys.2024.1480720
  227. Hering, S., Hughes, A. D., Timin, E. N., & Bolton, T. B. (1993). Modulation of calcium channels in arterial smooth muscle cells by dihydropyridine enantiomers [Journal Article]. J Gen Physiol, 101(3), 393–410. http://www.ncbi.nlm.nih.gov/pubmed/7682596
  228. Heusinkveld, M., Huberts, W., Lumens, J., Hughes, A., Delhaas, T., & Reesink, K. (2018). Augmentation index acts as ventricular-arterial coupling parameter (p. P3533) [Conference Paper].
  229. Heusinkveld, M. H. G., Delhaas, T., Lumens, J., Huberts, W., Spronck, B., Hughes, A. D., & Reesink, K. D. (2019). Augmentation index is not a proxy for wave reflection magnitude: mechanistic analysis using a computational model [Journal Article]. J Appl Physiol (1985), 127(2), 491–500. https://doi.org/10.1152/japplphysiol.00769.2018
  230. Hill, H., Geraghty, I., Hughes, A., Sever, P. S., & Schachter, M. (1987). Ergometrine and bronchospasm [Journal Article]. Anaesthesia, 42(10), 1115–1116. https://doi.org/10.1111/j.1365-2044.1987.tb05184.x
  231. Hill, P. B., Dora, K. A., Hughes, A. D., & Garland, C. J. (2000). The involvement of intracellular Ca(2+) in 5-HT(1B/1D) receptor-mediated contraction of the rabbit isolated renal artery [Journal Article]. Br J Pharmacol, 130(4), 835–842. https://doi.org/10.1038/sj.bjp.0703387
  232. Hobden, G., Reid, G., Chiesa, S. T., Wang, C., Jobbins, L., Mackay, C. E., Hughes, A. D., Ebmeier, K. P., Pitt, J., Kivimaki, M., Singh-Manoux, A., & Suri, S. (2025). Associations of aortic and carotid artery health with cerebrovascular markers and cognition in older adults from the Whitehall II imaging study [Journal Article]. BMC Med, 23(1), 330. https://doi.org/10.1186/s12916-025-04105-y
  233. Hodson, E. A. M., Ashley, C. C., Hughes, A. D., & Lymn, J. S. (1998). Regulation of phospholipase C-delta by GTP-binding proteins-rhoA as an inhibitory modulator [Journal Article]. BBA-Mol Cell Res, 1403(1), 97–101. https://doi.org/Doi 10.1016/S0167-4889(98)00028-7
  234. Hope, S. A., & Hughes, A. D. (2007). Drug effects on the mechanical properties of large arteries in humans [Journal Article]. Clin Exp Pharmacol Physiol, 34(7), 688–693. https://doi.org/10.1111/j.1440-1681.2007.04661.x
  235. Howe, L. D., Chaturvedi, N., Lawlor, D. A., Ferreira, D. L., Fraser, A., Davey Smith, G., Tilling, K., & Hughes, A. D. (2014). Rapid increases in infant adiposity and overweight/obesity in childhood are associated with higher central and brachial blood pressure in early adulthood [Journal Article]. J Hypertens, 32(9), 1789–1796. https://doi.org/10.1097/HJH.0000000000000269
  236. Hsieh, J. K., Kletsas, D., Clunn, G., Hughes, A. D., Schachter, M., & Demoliou-Mason, C. (2000). p53, p21(WAF1/CIP1), and MDM2 involvement in the proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells [Journal Article]. Arterioscler Thromb Vasc Biol, 20(4), 973–981. https://doi.org/10.1161/01.ATV.20.4.973
  237. Hsieh, J. K., Kletsas, D., Clunn, G., Hughes, A. D., Schachter, M., & Demoliou-Mason, C. (2000). p53, p21WAF1/CIP1, and MDM2 Involvement in Proliferation and Apoptosis in an In Vitro Model of Conditionally Immortalized Human Vascular Smooth Muscle Cells [Journal Article]. Arteriosclerosis, Thrombosis, and Vascular Biology, 20(3), 636–644. https://doi.org/10.1161/01.Atv.20.3.636
  238. Huang, Y., Gu, B., Salles, I. I., Crawley, Taylor, K. A., Yu, L., Ren, J., Liu, X., Emerson, M., Longstaff, C., Hughes, A. D., Thom, S. A., Xu, X. Y., & Chen, R. (2021). Fibrinogen-mimicking, multiarm nanovesicles for human thrombus-specific delivery of tissue plasminogen activator and targeted thrombolytic therapy [Journal Article]. Sci Adv, 7(23). https://doi.org/10.1126/sciadv.abf9033
  239. Huang, Y., Yu, L., Ren, J., Gu, B., Longstaff, C., Hughes, A. D., Thom, S. A., Xu, X. Y., & Chen, R. (2019). An activated-platelet-sensitive nanocarrier enables targeted delivery of tissue plasminogen activator for effective thrombolytic therapy [Journal Article]. J Control Release, 300, 1–12. https://doi.org/10.1016/j.jconrel.2019.02.033
  240. Huang, Z., Fonseca, R., Sharman, J. E., Park, C., Chaturvedi, N., Howe, L. D., Hughes, A. D., & Schultz, M. G. (2020). The influence of fitness on exercise blood pressure and its association with cardiac structure in adolescence [Journal Article]. Scand J Med Sci Sports, 30(6), 1033–1039. https://doi.org/10.1111/sms.13645
  241. Huang, Z., Park, C., Chaturvedi, N., Howe, L. D., Sharman, J. E., Hughes, A. D., & Schultz, M. G. (2021). Cardiorespiratory fitness, fatness, and the acute blood pressure response to exercise in adolescence [Journal Article]. Scand J Med Sci Sports. https://doi.org/10.1111/sms.13976
  242. Huang, Z., Sharman, J. E., Fonseca, R., Park, C., Chaturvedi, N., Davey Smith, G., Howe, L. D., Lawlor, D. A., Hughes, A. D., & Schultz, M. G. (2020). Masked hypertension and submaximal exercise blood pressure among adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) [Journal Article]. Scand J Med Sci Sports, 30(1), 25–30. https://doi.org/10.1111/sms.13525
  243. Hughes, A. (2014). One Pill, Four Questions: What We Still Need to Know About Reducing Cardiovascular Risk with Combination Therapy [Journal Article]. Cochrane Database Syst Rev, 4(4), ED000081. https://doi.org/Artn Ed000079 Doi 10.1002/14651858.Ed000079
  244. Hughes, A., Inkpen, P., & Sever, P. (1988). Action of dopamine on isolated human saphenous veins [Journal Article]. J Cardiovasc Pharmacol, 11(3), 373–377. https://doi.org/10.1097/00005344-198803000-00016
  245. Hughes, A., Manisty, C., Zambanini, A., Mayet, J., Poulter, N., Sever, P., Parker, K., & Thom, S. Lower augmentation index and wave reflection in hypertensive subjects treated with atorvastatin; An ASCOT-LLA substudy [Conference Proceedings]. Circulation, 116, 609.
  246. Hughes, A., Martin, G., Goldberg, P., Thom, S., & Sever, P. (1987). No evidence for a direct vasodilatory effect of celiprolol on human vasculature in vivo or in vitro. [Journal Article]. J Cardiovasc Pharmacol, 10(5), 589–592. http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=2447410&retmode=ref&cmd=prlinks
  247. Hughes, A., Martin, G., Thom, S., & Sever, P. (1985). Dopaminergic Mechanisms in Human Peripheral Vasculature [Journal Article]. J Hypertens, 3(6), 664–665. https://doi.org/Doi 10.1097/00004872-198512000-00024
  248. Hughes, A., Nielsen, H., Thom, S., Martin, G., & Sever, P. (1987). Differences between Human Resistance and Conduit Arteries [Journal Article]. Journal of Hypertension, 5(6), 762–762. https://doi.org/Doi 10.1097/00004872-198712000-00024
  249. Hughes, A., Parker, K., & Khir, A. (2018). Zero flow pressure (Pinfinity) is larger than mean circulatory filling pressure. A systematic review and meta-analysis [Journal Article]. Artery Res, 24. https://doi.org/https://doi.org/10.1016/j.artres.2018.10.106
  250. Hughes, A., Schachter, M., & Sever, P. (1989). Autoradiographic Localization of Dopamine D1 Receptors in Human Renal Cortex [Journal Article]. Biochem Soc Trans, 17(5), 918–919. https://doi.org/10.1042/bst0170918
  251. Hughes, A., & Sever, P. (1989). Specific Binding of I125 SCH-23982, a Selective Dopamine (D1) Receptor Ligand to Plasma-Membranes Derived from Human-Kidney Cortex [Journal Article]. Biochem Pharmacol, 38(5), 781–785. https://doi.org/Doi 10.1016/0006-2952(89)90231-1
  252. Hughes, A., Smith, N. I., & Wallace, H. M. (2003). Polyamines reverse non-steroidal anti-inflammatory drug-induced toxicity in human colorectal cancer cells [Journal Article]. Biochemical Journal, 374(2), 481–488. https://doi.org/10.1042/BJ20030280
  253. Hughes, A., Thom, S., Goldberg, P., Martin, G., & Sever, P. (1988). Direct effect of alpha-human atrial natriuretic peptide on human vasculature in vivo and in vitro [Journal Article]. Clin Sci (Lond), 74(2), 207–211. http://www.ncbi.nlm.nih.gov/pubmed/2962803
  254. Hughes, A., Thom, S., Martin, G., Redman, D., Hasan, S., & Sever, P. (1986). The action of a dopamine (DA1) receptor agonist, fenoldopam in human vasculature in vivo and in vitro [Journal Article]. Br J Clin Pharmacol, 22(5), 535–540. http://www.ncbi.nlm.nih.gov/pubmed/2878679
  255. Hughes, A., Thom, S., Redman, D., & Sever, P. (1986). Demonstration of Vascular Dopamine-Receptors in the Human Forearm Arterial Circulation [Journal Article]. Journal of Hypertension, 4(6), 791–792. https://doi.org/Doi 10.1097/00004872-198612000-00019
  256. Hughes, A., Wang, J. J., Bouwmeester, C., Davies, J., Shrive, N., Tyberg, J., & Parker, K. (2012). The reservoir-wave paradigm [Journal Article]. J Hypertens, 30(9), 1880–1881; author reply 1881–1883. https://doi.org/10.1097/HJH.0b013e3283560960
  257. Hughes, A. D. (1995). Calcium channels in vascular smooth muscle cells [Journal Article]. J Vasc Res, 32(6), 353–370. https://doi.org/10.1159/000159111
  258. Hughes, A. D. (1995). Increase in tone and intracellular Ca2+ in rabbit isolated ear artery by platelet-derived growth factor [Journal Article]. Br J Pharmacol, 114(1), 138–142. https://doi.org/10.1111/j.1476-5381.1995.tb14917.x
  259. Hughes, A. D. (1998). Molecular and cellular mechanisms of action of angiotensin II (AT(1)) receptors in vascular smooth muscle [Journal Article]. J Hum Hypertens, 12(5), 275–281. https://doi.org/DOI 10.1038/sj.jhh.1000635
  260. Hughes, A. D. (2000). AT(1)-signalling in vascular smooth muscle [Journal Article]. J Renin Angiotensin Aldosterone Syst, 1(2), 125–130. https://doi.org/10.3317/jraas.2000.014
  261. Hughes, A. D. (2004). How do thiazide and thiazide-like diuretics lower blood pressure? [Journal Article]. J Renin Angiotensin Aldosterone Syst, 5(4), 155–160. https://doi.org/10.3317/jraas.2004.034
  262. Hughes, A. D. (2006). Retinal microvascular abnormalities, cardiovascular mortality linked [Journal Article]. Retina Today, Fall, 14–11.
  263. Hughes, A. D. (2007). The clinical assessment of retinal microvascular structure and therapeutic implications [Journal Article]. Curr Treat Options Cardiovasc Med, 9(3), 236–241. http://www.ncbi.nlm.nih.gov/pubmed/17601388
  264. Hughes, A. D. (2010). A ticking timebomb [Journal Article]. Public Services Review, 1, 1–2.
  265. Hughes, A. D. (2012). Genetic and early life influences on the human retinal microcirculation [Journal Article]. Basic Clin Pharmacol Toxicol, 110(1), 19–25. https://doi.org/10.1111/j.1742-7843.2011.00817.x
  266. Hughes, A. D. (2013). Commentary: ’On the cards’: collective investigation of disease and medical life histories in the nineteenth century [Journal Article]. Int J Epidemiol, 42(3), 683–688. https://doi.org/10.1093/ije/dyt062
  267. Hughes, A. D. (2014). Ahead of the curve: waveform analysis of blood pressure, reflection magnitude, and outcomes [Journal Article]. Hypertension, 64(5), 929–930. https://doi.org/10.1161/HYPERTENSIONAHA.114.03998
  268. Hughes, A. D. (2015). Optimality, Cost Minimization and the Design of Arterial Networks [Journal Article]. Artery Res, 10, 1–10. https://doi.org/10.1016/j.artres.2015.01.001
  269. Hughes, A. D. (2018). Calcium Channel Blockers [Book Section]. In G. L. Bakris & M. J. Sorrentino (Eds.), Hypertension : a companion to Braunwald’s heart disease (pp. 242–253). Elsevier, Inc.
  270. Hughes, A. D., Bathula, R., Park, C., Tillin, T., Wit, N., McG., T. S., & Chaturvedi, N. (2013). Microcirculatory rarefaction in South Asians - a potential mechanism for increased cardiovascular risk and diabetes [Journal Article]. PLoS One, 8(10), e76680. https://doi.org/10.1371/journal.pone.0076680
  271. Hughes, A. D., & Bolton, T. B. (1995). Action of angiotensin II, 5-hydroxytryptamine and adenosine triphosphate on ionic currents in single ear artery cells of the rabbit [Journal Article]. Br J Pharmacol, 116(3), 2148–2154. https://doi.org/10.1111/j.1476-5381.1995.tb16424.x
  272. Hughes, A. D., & Chaturvedi, N. (2017). Estimation of Maximal Oxygen Consumption and Heart Rate Recovery Using the Tecumseh Sub-Maximal Step Test and their Relationship to Cardiovascular Risk Factors [Journal Article]. Artery Res, 18, 29–35. https://doi.org/10.1016/j.artres.2017.02.005
  273. Hughes, A. D., & Chaturvedi, N. (2021). Corrigendum to "Estimation of maximal oxygen consumption and heart rate recovery using the Tecumseh sub-maximal step test and their relationship to cardiovascular risk factors" [Artery Research 18 (June 2017) 29-35] [Journal Article]. Artery Res, 27(1), 51. https://doi.org/10.2991/artres.k.210210.001
  274. Hughes, A. D., Clunn, G. F., Refson, J., & Demoliou-Mason, C. (1996). Platelet-derived growth factor (PDGF): actions and mechanisms in vascular smooth muscle [Journal Article]. Gen Pharmacol, 27(7), 1079–1089. http://www.ncbi.nlm.nih.gov/pubmed/8981052
  275. Hughes, A. D., Clunn, G. F., & Schachter, M. (1994). A Comparison of Calcium-Channel Currents in Vascular Smooth-Muscle Cells from Watanabe Hereditary Hypercholesterolemic and New-Zealand White-Rabbits [Journal Article]. Biochem Soc Trans, 22(3), S361–S361. https://doi.org/10.1042/bst022361s
  276. Hughes, A. D., Clunn, G. F., & Schachter, M. (1994). Low density lipoprotein and calcium homeostasis in human vascular smooth muscle cells [Journal Article]. Biochem Soc Trans, 22(2), 145S. https://doi.org/10.1042/bst022145s
  277. Hughes, A. D., Coady, E., Raynor, S., Mayet, J., Wright, A. R., Shore, A. C., Kooner, J. S., Thom, S. A., & Chaturvedi, N. (2007). Reduced endothelial progenitor cells in European and South Asian men with atherosclerosis [Journal Article]. Eur J Clin Invest, 37(1), 35–41. https://doi.org/10.1111/j.1365-2362.2007.01743.x
  278. Hughes, A. D., Davey Smith, G., Howe, L. D., Lawlor, D., Jones, S., Park, C. M., & Chaturvedi, N. (2024). Differences between brachial and aortic blood pressure in adolescence and their implications for diagnosis of hypertension [Journal Article]. J Hypertens, 42(8), 1382–1389. https://doi.org/10.1097/HJH.0000000000003743
  279. Hughes, A. D., Davies, J. E., Francis, D., Mayet, J., & Parker, K. H. (2008). Peripheral augmentation index and wave reflection in the radial artery [Journal Article]. Hypertension, 51(6), e45–6; author reply e47. https://doi.org/10.1161/HYPERTENSIONAHA.108.110486
  280. Hughes, A. D., Davies, J. E., & Parker, K. H. (2013). The importance of wave reflection: A comparison of wave intensity analysis and separation of pressure into forward and backward components [Journal Article]. Conf Proc IEEE Eng Med Biol Soc, 2013, 229–232. https://doi.org/10.1109/EMBC.2013.6609479
  281. Hughes, A. D., Eastwood, S. V., Tillin, T., & Chaturvedi, N. (2021). Antihypertensive Medication Use and Its Effects on Blood Pressure and Haemodynamics in a Tri-ethnic Population Cohort: Southall and Brent Revisited (SABRE) [Journal Article]. Front Cardiovasc Med, 8, 795267. https://doi.org/10.3389/fcvm.2021.795267
  282. Hughes, A. D., Falaschetti, E., Witt, N., Wijetunge, S., Thom, S. A., Tillin, T., Aldington, S. J., & Chaturvedi, N. (2016). Association of Retinopathy and Retinal Microvascular Abnormalities With Stroke and Cerebrovascular Disease [Journal Article]. Stroke, 47(11), 2862–2864. https://doi.org/10.1161/STROKEAHA.116.014998
  283. Hughes, A. D., Hering, S., & Bolton, T. B. (1990). The Action of Caffeine on Inward Barium Current through Voltage-Dependent Calcium Channels in Single-Rabbit Ear Artery Cells [Journal Article]. Pflugers Archiv-European Journal of Physiology, 416(4), 462–466. https://doi.org/Doi 10.1007/Bf00370755
  284. Hughes, A. D., Hering, S., & Bolton, T. B. (1990). Evidence That Agonist and Antagonist Enantiomers of the Dihydropyridine Pn-202-791 Act at Different Sites on the Voltage-Dependent Calcium-Channel of Vascular Muscle [Journal Article]. Br J Pharmacol, 101(1), 3–5. https://doi.org/10.1111/j.1476-5381.1990.tb12076.x
  285. Hughes, A. D., Martinez-Perez, E., Jabbar, A. S., Hassan, A., Witt, N. W., Mistry, P. D., Chapman, N., Stanton, A. V., Beevers, G., Pedrinelli, R., Parker, K. H., & Thom, S. A. (2006). Quantification of topological changes in retinal vascular architecture in essential and malignant hypertension [Journal Article]. J Hypertens, 24(5), 889–894. https://doi.org/10.1097/01.hjh.0000222759.61735.98
  286. Hughes, A. D., Nielsen, H., & Sever, P. S. (1989). The effect of atrial natriuretic peptide on human isolated resistance arteries [Journal Article]. Br J Pharmacol, 97(4), 1027–1030. https://doi.org/10.1111/j.1476-5381.1989.tb12558.x
  287. Hughes, A. D., Nielsen, H., Thom, S., Martin, G. N., & Sever, P. S. (1987). The effect of atrial natriuretic peptide on human blood vessels [Journal Article]. J Hypertens, 5(Supplement 5), S51–S53.
  288. Hughes, A. D., Park, C., Davies, J., Francis, D., Mc, G. T. S. A., Mayet, J., & Parker, K. H. (2013). Limitations of augmentation index in the assessment of wave reflection in normotensive healthy individuals [Journal Article]. PLoS One, 8(3), e59371. https://doi.org/10.1371/journal.pone.0059371
  289. Hughes, A. D., Park, C., March, K., Coady, E., Khir, A., Chaturvedi, N., & Thom, S. A. (2013). A randomized placebo controlled double blind crossover study of pioglitazone on left ventricular diastolic function in type 2 diabetes [Journal Article]. Int J Cardiol, 167(4), 1329–1332. https://doi.org/10.1016/j.ijcard.2012.03.179
  290. Hughes, A. D., Park, C., Ramakrishnan, A., Mayet, J., Chaturvedi, N., & Parker, K. H. (2020). Feasibility of Estimation of Aortic Wave Intensity Using Non-invasive Pressure Recordings in the Absence of Flow Velocity in Man [Journal Article]. Front Physiol, 11, 550. https://doi.org/10.3389/fphys.2020.00550
  291. Hughes, A. D., & Parker, K. H. (2009). Forward and backward waves in the arterial system: impedance or wave intensity analysis? [Journal Article]. Med Biol Eng Comput, 47(2), 207–210. https://doi.org/10.1007/s11517-009-0444-1
  292. Hughes, A. D., & Parker, K. H. (2020). The modified arterial reservoir: An update with consideration of asymptotic pressure (Pinfinity) and zero-flow pressure (Pzf) [Journal Article]. Proc Inst Mech Eng H, 234(11), 1288–1299. https://doi.org/10.1177/0954411920917557
  293. Hughes, A. D., Parker, K. H., & Davies, J. E. (2008). Waves in arteries: A review of wave intensity analysis in the systemic and coronary circulations [Journal Article]. Artery Res, 2(2), 51–59. https://doi.org/10.1016/j.artres.2008.02.002
  294. Hughes, A. D., Parkinson, N. A., & Wijetunge, S. (1996). alpha(2)-Adrenoceptor activation increases calcium channel currents in single vascular smooth muscle cells isolated from human omental resistance arteries [Journal Article]. Journal of Vascular Research, 33(1), 25–31. https://doi.org/10.1159/000159128
  295. Hughes, A. D., Patel, M., Wijetunge, S., Clunn, G., & Schachter, M. (1995). Comparison of effects of platelet-derived growth factor isoforms on signaling and DNA synthesis of human cultured saphenous vein cells [Journal Article]. J Cardiovasc Pharmacol, 25(3), 481–485. https://doi.org/10.1097/00005344-199503000-00020
  296. Hughes, A. D., Peterzan, M. A., Chaturvedi, N., & Hardy, R. (2012). Response to Potency of Office Blood Pressure From Hydrochlorothiazide and Chlorthalidone Fails to Explain Cardiovascular Events [Journal Article]. Hypertension, 60(3), E23–E23. https://doi.org/10.1161/Hypertensionaha.112.200428
  297. Hughes, A. D., & Schachter, M. (1994). Hypertension and blood vessels [Journal Article]. Br Med Bull, 50(2), 356–370. https://doi.org/10.1093/oxfordjournals.bmb.a072896
  298. Hughes, A. D., & Schachter, M. (1994). Multiple pathways for entry of calcium and other divalent cations in a vascular smooth muscle cell line (A7r5) [Journal Article]. Cell Calcium, 15(4), 317–330. https://doi.org/10.1016/0143-4160(94)90071-X
  299. Hughes, A. D., & Schachter, M. (1995). Alf4- Inhibits Influx of Ca2+ into Vascular Smooth-Muscle Cells [Journal Article]. Biochem Soc Trans, 23(2), S171–S171. https://doi.org/10.1042/bst023171s
  300. Hughes, A. D., Schachter, M., Patel, M. K., Callagher, K. L., & Sever, P. S. (1989). Intracellular pH and Calcium in Vascular Smooth-Muscle [Journal Article]. Biochem Soc Trans, 17(3), 506–507. ://WOS:A1989U840100048</span></li>
  301. Hughes, A. D., & Sever, P. S. (1989). The action of dopamine and vascular dopamine (DA1) receptor agonists on human isolated subcutaneous and omental small arteries [Journal Article]. Br J Pharmacol, 97(3), 950–956. https://doi.org/10.1111/j.1476-5381.1989.tb12036.x
  302. Hughes, A. D., & Sever, P. S. (1989). Action of fenoldopam, a selective dopamine (DA1) receptor agonist, on isolated human arteries [Journal Article]. Blood Vessels, 26(2), 119–127. http://www.ncbi.nlm.nih.gov/pubmed/2474340
  303. Hughes, A. D., Sinclair, A. M., Geroulakos, G., Mayet, J., Mackay, J., Shahi, M., Thom, S., Nicolaides, A., & Sever, P. S. (1993). Structural changes in the heart and carotid arteries associated with hypertension in humans [Journal Article]. J Hum Hypertens, 7(4), 395–397. http://www.ncbi.nlm.nih.gov/pubmed/8410934
  304. Hughes, A. D., Sinclair, A. M., Geroulakos, G., Mayet, J., Mackay, J., Shahi, M., Thom, S., Nicolaides, A., & Sever, P. S. (1995). Structural changes in the cardiovascular system of untreated essential hypertensives [Journal Article]. Blood Press, 4(1), 42–47. http://www.ncbi.nlm.nih.gov/pubmed/7735496
  305. Hughes, A. D., Stanton, A. V., Jabbar, A. S., Chapman, N., Martinez-Perez, M. E., & Mc, G. T. S. A. (2008). Effect of antihypertensive treatment on retinal microvascular changes in hypertension [Journal Article]. J Hypertens, 26(8), 1703–1707. https://doi.org/10.1097/HJH.0b013e328304b072
  306. Hughes, A. D., & Thom, S. (2001). Wearing your heart in your sleeve? [Journal Article]. Eur Heart J, 22(13), 1071–1073. https://doi.org/10.1053/euhj.2000.2575
  307. Hughes, A. D., Thom, S. A., Martin, G. N., Nielsen, H., Hair, W. M., Schachter, M., & Sever, P. S. (1988). Size and site-dependent heterogeneity of human vascular responses in vitro [Journal Article]. J Hypertens Suppl, 6(4), S173–5. https://www.ncbi.nlm.nih.gov/pubmed/2977161
  308. Hughes, A. D., Thom, S. A., Woodall, N., Schachter, M., Hair, W. M., Martin, G. N., & Sever, P. S. (1989). Human vascular responses to endothelin-1: observations in vivo and in vitro [Journal Article]. J Cardiovasc Pharmacol, 13 Suppl 5, S225–8. https://www.ncbi.nlm.nih.gov/pubmed/2473321
  309. Hughes, A. D., Thom, S. A., Woodall, N. M., Redman, D., & Sever, P. S. (1987). Dopamine produces forearm vasodilatation following alpha-adrenoceptor blockade by an action on vascular dopamine (DA1) receptors in man [Journal Article]. J Hypertens, 5(3), 337–340. https://doi.org/10.1097/00004872-198706000-00012
  310. Hughes, A. D., Thom, S. A. M., Woodall, N., Schachter, M., Hair, W. M., Martin, G. N., & Sever, P. S. (1989). Human Vascular-Responses to Endothelin-1 - Observations Invivo and Invitro [Journal Article]. Journal of Cardiovascular Pharmacology, 13, S225–S228. https://doi.org/Doi 10.1097/00005344-198900135-00067
  311. Hughes, A. D., & Wijetunge, S. (1993). The action of amlodipine on voltage-operated calcium channels in vascular smooth muscle [Journal Article]. Br J Pharmacol, 109(1), 120–125. https://doi.org/10.1111/j.1476-5381.1993.tb13540.x
  312. Hughes, A. D., & Wijetunge, S. (1998). Role of tyrosine phosphorylation in excitation-contraction coupling in vascular smooth muscle [Journal Article]. Acta Physiol Scand, 164(4), 457–469. https://doi.org/10.1046/j.1365-201X.1998.00446.x
  313. Hughes, A. D., Wijetunge, S., & Parkinson, N. A. (1994). Isolation of single vascular smooth muscle cells from human omental resistance arteries [Journal Article]. J Hum Hypertens, 8(8), 615–618. https://www.ncbi.nlm.nih.gov/pubmed/7990094
  314. Hughes, A. D., Wong, T. Y., Witt, N., Evans, R., Thom, S. A., Klein, B. E., Chaturvedi, N., & Klein, R. (2009). Determinants of retinal microvascular architecture in normal subjects [Journal Article]. Microcirculation, 16(2), 159–166. https://doi.org/10.1080/10739680802353868
  315. Hughes, A. R., Sherriff, A., Lawlor, D. A., Ness, A. R., & Reilly, J. J. (2011). Timing of excess weight gain in the Avon Longitudinal Study of Parents and Children (ALSPAC) [Journal Article]. Pediatrics, 127(3), e730–6. https://doi.org/10.1542/peds.2010-0959
  316. Hussain, S. M., Kahonen, M., Raitakari, O. T., Skilton, M. R., Witt, N., Chaturvedi, N., Hutri-Kahonen, N., Lehtimaki, T., Vaahtoranta-Lehtonen, H., Juonala, M., Wijetunge, S., Hughes, A. D., Mc, G. T. S. A., Metha, A., & Tapp, R. J. (2015). Impact of fetal growth and preterm birth on the retinal microvasculature in mid-adulthood [Journal Article]. Microcirculation, 22(4), 285–293. https://doi.org/10.1111/micc.12197
  317. Ibrahim, J., Berk, B. C., & Hughes, A. D. (2006). Comparison of simultaneous measurements of blood pressure by tail-cuff and carotid arterial methods in conscious spontaneously hypertensive and Wistar-Kyoto rats [Journal Article]. Clin Exp Hypertens, 28(1), 57–72. https://doi.org/10.1080/10641960500386817
  318. Ibrahim, J., Hughes, A. D., Schachter, M., & Sever, P. S. (1996). Depletion of resistance vessel polyamines attenuates angiotensin II induced blood pressure rise in rats [Journal Article]. Clin Exp Hypertens, 18(6), 811–830. https://doi.org/10.3109/10641969609081782
  319. Ibrahim, J., Hughes, A. D., Schachter, M., & Sever, P. S. (1996). Enhanced tissue polyamine content in the spontaneously hypertensive rat [Journal Article]. Clin Exp Pharmacol Physiol, 23(5), 410–414. https://doi.org/10.1111/j.1440-1681.1996.tb02750.x
  320. Ibrahim, J., Hughes, A. D., & Sever, P. S. (2000). Action of angiotensin II on DNA synthesis by human saphenous vein in organ culture [Journal Article]. Hypertension, 36(5), 917–921. https://doi.org/10.1161/01.HYP.36.5.917
  321. Ibrahim, J., Schachter, M., Hughes, A. D., & Sever, P. S. (1995). Role of polyamines in hypertension induced by angiotensin II [Journal Article]. Cardiovasc Res, 29(1), 50–56. https://doi.org/10.1016/S0008-6363(96)88546-4
  322. Ibrahim, J., Schachter, M., Hughes, A. D., & Sever, P. S. (1999). Low dose indapamide plus perindopril combination effects on cardiovascular structure and function in genetic hypertension [Journal Article]. Clin Exp Pharmacol Physiol, 26(8), 622–627. https://doi.org/10.1046/j.1440-1681.1999.03095.x
  323. Imahori, Y., Frost, C., Mathiesen, E. B., Ryabikov, A., Kudryavtsev, A. V., Malyutina, S., Kornev, M., Hughes, A. D., Hopstock, L. A., & Leon, D. A. (2020). Effect of adiposity on differences in carotid plaque burden in studies conducted in Norway and Russia: a cross-sectional analysis of two populations at very different risk of cardiovascular mortality [Journal Article]. BMJ Open, 10(5), e036583. https://doi.org/10.1136/bmjopen-2019-036583
  324. Imahori, Y., Mathiesen, E. B., Morgan, K. E., Frost, C., Hughes, A. D., Hopstock, L. A., Johnsen, S. H., Emaus, N., & Leon, D. A. (2020). The association between anthropometric measures of adiposity and the progression of carotid atherosclerosis [Journal Article]. BMC Cardiovasc Disord, 20(1), 138. https://doi.org/10.1186/s12872-020-01417-0
  325. Ioannou, A., Massa, P., Patel, R. K., Razvi, Y., Porcari, A., Rauf, M. U., Jiang, A., Cabras, G., Filisetti, S., Bolhuis, R. E., Bandera, F., Venneri, L., Martinez-Naharro, A., Law, S., Kotecha, T., Virsinskaite, R., Knight, D. S., Emdin, M., Petrie, A., … Fontana, M. (2023). Conventional heart failure therapy in cardiac ATTR amyloidosis [Journal Article]. Eur Heart J, 44(31), 2893–2907. https://doi.org/10.1093/eurheartj/ehad347
  326. Islam, M., Jafar, T. H., Bux, R., Hashmi, S., Chaturvedi, N., & Hughes, A. D. (2014). Association of parental blood pressure with retinal microcirculatory abnormalities indicative of endothelial dysfunction in children [Journal Article]. J Hypertens, 32(3), 598–605. https://doi.org/10.1097/HJH.0000000000000063
  327. J. Bhatt, B., Mohammad Amir, H., Jones, S., Hughes, A., & Orini, M. (2024). Comparison between a Medical-Grade Device and a Cuffless Consumer-Grade Device for Day and Night Blood Pressure Monitoring [Conference Paper]. https://doi.org/10.22489/CinC.2024.432
  328. Jackson, M., Wood, N. B., Zhao, S., Augst, A., Wolfe, J. H., Gedroyc, W. M. W., Hughes, A. D., Thom, S. A. M. G., & Xu, X. Y. (2009). Low wall shear stress predicts subsequent development of wall hypertrophy in lower limb bypass grafts [Journal Article]. Artery Res, 3(1), 32–38. https://doi.org/10.1016/j.artres.2009.01.001
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  331. Jamieson, A., Chico, T. J. A., Jones, S., Chaturvedi, N., Hughes, A. D., & Orini, M. (2025). A guide to consumer-grade wearables in cardiovascular clinical care and population health for non-experts [Journal Article]. NPJ Cardiovasc Health, 2(1), 44. https://doi.org/10.1038/s44325-025-00082-6
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  333. Jamieson, A., Jones, S., Steves, C., Timpson, N., Chaturvedi, N., Hughes, A., & Orini, M. (2024). Comparison between Smartwatch-Derived and CPET-Measured VO2Max [Conference Paper]. https://doi.org/10.22489/CinC.2024.352
  334. Jamieson, A., Saikhan, L. A., Raman, B., Alghamdi, L., Cheetham, N. J., Conde, P., Dobson, R., Fernandez-Sanles, A., Folarin, A., Goudswaard, L. J., Hamill Howes, L., Jones, S., Neubauer, S., Orini, M., Pierce, I., Ranjan, Y., Rapala, A., Smith, S. M., Sudre, C., … Hughes, A. (2025). Cohort profile: characterisation, determinants, mechanisms and consequences of the long-term effects of COVID-19 - providing the evidence base for health care services (CONVALESCENCE) in the UK [Journal Article]. BMJ Open, 15(6), e094760. https://doi.org/10.1136/bmjopen-2024-094760
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  336. Jensen, P. E., Hughes, A., Boonen, H. C., & Aalkjaer, C. (1993). Force, membrane potential, and [Ca2+]i during activation of rat mesenteric small arteries with norepinephrine, potassium, aluminum fluoride, and phorbol ester. Effects of changes in pHi [Journal Article]. Circ Res, 73(2), 314–324. https://www.ncbi.nlm.nih.gov/pubmed/8330374 http://circres.ahajournals.org/content/circresaha/73/2/314.full.pdf
  337. Jiang, Y., Punjabi, K., Pierce, I., Knight, D., Yao, T., Steeden, J., Hughes, A. D., Muthurangu, V., & Davies, R. (2025). A machine learning algorithm for creating isotropic 3D aortic segmentations from routine cardiac MR localizers [Journal Article]. Magn Reson Imaging, 115, 110253. https://doi.org/10.1016/j.mri.2024.110253
  338. Johnson, W., Kuh, D., Tikhonoff, V., Charakida, M., Woodside, J., Whincup, P., Hughes, A. D., Deanfield, J. E., & Hardy, R. (2014). Body mass index and height from infancy to adulthood and carotid intima-media thickness at 60 to 64 years in the 1946 British Birth Cohort Study [Journal Article]. Arterioscler Thromb Vasc Biol, 34(3), 654–660. https://doi.org/10.1161/ATVBAHA.113.302572
  339. Jones, R., Hardy, R., Sattar, N., Deanfield, J. E., Hughes, A., Kuh, D., Murray, E. T., Whincup, P. H., & Thomas, C. (2015). Novel coronary heart disease risk factors at 60-64 years and life course socioeconomic position: The 1946 British birth cohort [Journal Article]. Atherosclerosis, 238(1), 70–76. https://doi.org/10.1016/j.atherosclerosis.2014.11.011
  340. Jones, S., Chiesa, S. T., Chaturvedi, N., & Hughes, A. D. (2016). Recent developments in near-infrared spectroscopy (NIRS) for the assessment of local skeletal muscle microvascular function and capacity to utilise oxygen [Journal Article]. Artery Res, 16, 25–33. https://doi.org/10.1016/j.artres.2016.09.001
  341. Jones, S., D’Silva, A., Bhuva, A., Lloyd, G., Manisty, C., Moon, J. C., Sharma, S., & Hughes, A. D. (2017). Improved Exercise-Related Skeletal Muscle Oxygen Consumption Following Uptake of Endurance Training Measured Using Near-Infrared Spectroscopy [Journal Article]. Front Physiol, 8, 1018. https://doi.org/10.3389/fphys.2017.01018
  342. Jones, S., Kinsella, M., Torlasco, C., Kaynezhad, P., de Roever, I., Moon, J. C., Hughes, A. D., & Bale, G. (2020). Correction to: Improvements in Skeletal Muscle Can Be Detected Using Broadband NIRS in First-Time Marathon Runners [Journal Article]. Adv Exp Med Biol, 1232, C1. https://doi.org/10.1007/978-3-030-34461-0_54
  343. Jones, S., Kinsella, M., Torlasco, C., Kaynezhad, P., de Roever, I., Moon, J. C., Hughes, A. D., & Bale, G. (2020). Improvements in Skeletal Muscle Can Be Detected Using Broadband NIRS in First-Time Marathon Runners [Journal Article]. Adv Exp Med Biol, 1232, 245–251. https://doi.org/10.1007/978-3-030-34461-0_31
  344. Jones, S., Lumens, J., Sohaib, S. M. A., Finegold, J. A., Kanagaratnam, P., Tanner, M., Duncan, E., Moore, P., Leyva, F., Frenneaux, M., Mason, M., Hughes, A. D., Francis, D. P., Whinnett, Z. I., Chaturvedi, N., Davies, W., Lim, B., Lefroy, D., Peters, N. S., … Dayer, M. (2017). Cardiac resynchronization therapy: Mechanisms of action and scope for further improvement in cardiac function [Journal Article]. Europace, 19(7), 1178–1186. https://doi.org/10.1093/europace/euw136
  345. Jones, S., Schultz, M. G., Park, C., Tillin, T., Chaturvedi, N., & Hughes, A. D. (2022). Antihypertensive treatment effect on exercise blood pressure and exercise capacity in older adults [Journal Article]. J Hypertens, 40(9), 1682–1691. https://doi.org/10.1097/HJH.0000000000003201
  346. Jones, S., Schultz, M. G., Tillin, T., Park, C., Williams, S., Chaturvedi, N., & Hughes, A. D. (2021). Sex differences in the contribution of different physiological systems to physical function in older adults [Journal Article]. Geroscience, 43(1), 443–455. https://doi.org/10.1007/s11357-021-00328-y
  347. Jones, S., Shun-Shin, M. J., Cole, G. D., Sau, A., March, K., Williams, S., Kyriacou, A., Hughes, A. D., Mayet, J., Frenneaux, M., Manisty, C. H., Whinnett, Z. I., & Francis, D. P. (2014). Applicability of the iterative technique for cardiac resynchronization therapy optimization: full-disclosure, 50-sequential-patient dataset of transmitral Doppler traces, with implications for future research design and guidelines [Journal Article]. Europace, 16(4), 541–550. https://doi.org/10.1093/europace/eut257
  348. Jones, S., Tillin, T., Park, C., Williams, S., Rapala, A., Al Saikhan, L., Eastwood, S. V., Richards, M., Hughes, A. D., & Chaturvedi, N. (2020). Cohort Profile Update: Southall and Brent Revisited (SABRE) study: a UK population-based comparison of cardiovascular disease and diabetes in people of European, South Asian and African Caribbean heritage [Journal Article]. Int J Epidemiol, 49(5), 1441–1442e. https://doi.org/10.1093/ije/dyaa135
  349. Jones, S., Tillin, T., Williams, S., Coady, E., Chaturvedi, N., & Hughes, A. D. (2017). Assessment of Exercise Capacity and Oxygen Consumption Using a 6 min Stepper Test in Older Adults [Journal Article]. Front Physiol, 8(Jun), 408. https://doi.org/10.3389/fphys.2017.00408
  350. Jones, S., Tillin, T., Williams, S., Eastwood, S. V., Hughes, A. D., & Chaturvedi, N. (2020). Type 2 diabetes does not account for ethnic differences in exercise capacity or skeletal muscle function in older adults [Journal Article]. Diabetologia, 63(3), 624–635. https://doi.org/10.1007/s00125-019-05055-w
  351. Jones, S., Tillin, T., Williams, S., Rapala, A., Chaturvedi, N., & Hughes, A. D. (2022). Skeletal Muscle Tissue Saturation Changes Measured Using Near Infrared Spectroscopy During Exercise Are Associated With Post-Occlusive Reactive Hyperaemia [Journal Article]. Front Physiol, 13, 919754. https://doi.org/10.3389/fphys.2022.919754
  352. Jones, S. H., Park, C., Chiesa, S. T., Chaturvedi, N., & Hughes, A. D. (2024). The Impact Of Physical Activity In Adolescence On Cardiovascular Health In Early Adulthood [Journal Article]. Medicine & Science in Sports & Exercise, 56(10), 691–692. https://doi.org/10.1249/01.mss.0001058576.93194.ed
  353. Joshi, R., Wannamethee, G., Engmann, J., Gaunt, T., Lawlor, D. A., Price, J., Papacosta, O., Shah, T., Tillin, T., Whincup, P., Chaturvedi, N., Kivimaki, M., Kuh, D., Kumari, M., Hughes, A. D., Casas, J. P., Humphries, S. E., Hingorani, A. D., Schmidt, A. F., & Consortium, U. (2021). Establishing reference intervals for triglyceride-containing lipoprotein subfraction metabolites measured using nuclear magnetic resonance spectroscopy in a UK population [Journal Article]. Ann Clin Biochem, 58(1), 47–53. https://doi.org/10.1177/0004563220961753
  354. Joshi, R., Wannamethee, S. G., Engmann, J., Gaunt, T., Lawlor, D. A., Price, J., Papacosta, O., Shah, T., Tillin, T., Chaturvedi, N., Kivimaki, M., Kuh, D., Kumari, M., Hughes, A. D., Casas, J. P., Humphries, S., Hingorani, A. D., & Schmidt, A. F. (2020). Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke: A prospective analysis in 11,560 adults [Journal Article]. Eur J Prev Cardiol, 27(15), 1617–1626. https://doi.org/10.1177/2047487319899621
  355. Joy, G., Lopes, L. R., Webber, M., Ardissino, A. M., Wilson, J., Chan, F., Pierce, I., Hughes, R. K., Moschonas, K., Shiwani, H., Jamieson, R., Velazquez, P. P., Vijayakumar, R., Dall’Armellina, E., Macfarlane, P. W., Manisty, C., Kellman, P., Davies, R. H., Tome, M., … Captur, G. (2024). Electrophysiological Characterization of Subclinical and Overt Hypertrophic Cardiomyopathy by Magnetic Resonance Imaging-Guided Electrocardiography [Journal Article]. J Am Coll Cardiol, 83(11), 1042–1055. https://doi.org/10.1016/j.jacc.2024.01.006
  356. Justesen, B. L., Mistry, P., Chaturvedi, N., Thom, S. A., Witt, N., Kohler, D., Hughes, A. D., & Sjolie, A. K. (2010). Retinal arterioles have impaired reactivity to hyperoxia in type 1 diabetes [Journal Article]. Acta Ophthalmol, 88(4), 453–457. https://doi.org/10.1111/j.1755-3768.2009.01557.x
  357. Kazmi, N., Elliott, H. R., Burrows, K., Tillin, T., Hughes, A. D., Chaturvedi, N., Gaunt, T. R., & Relton, C. L. (2020). Associations between high blood pressure and DNA methylation [Journal Article]. PLoS One, 15(1), e0227728. https://doi.org/10.1371/journal.pone.0227728
  358. Kelleher, E., Fulton, A., Dolan, E., O’Brien, E. T., Witt, N., Hughes, A. D., Thom, S. A., & Stanton, V., A. (2012). Effects of dual nitric oxide synthase and cyclooxygenase inhibition on retinal vascular responses-a novel measure of microvascular endothelial function? [Journal Article]. Journal of Human Hypertension, 26(10), 619–620.
  359. Kerrison, P. D., Innes, M., Macleod, A., McCormick, E., Elbourne, P. D., Stanley, M. S., Hughes, A. D., & Kelly, M. S. (2020). Comparing the effectiveness of twine- and binder-seeding in the Laminariales species Alaria esculenta and Saccharina latissima [Journal Article]. J Appl Phycol, 32(4), 2173–2181. https://doi.org/10.1007/s10811-020-02069-5
  360. Kettunen, J., Holmes, M. V., Allara, E., Anufrieva, O., Ohukainen, P., Oliver-Williams, C., Wang, Q., Tillin, T., Hughes, A. D., Kahonen, M., Lehtimaki, T., Viikari, J., Raitakari, O. T., Salomaa, V., Jarvelin, M. R., Perola, M., Davey Smith, G., Chaturvedi, N., Danesh, J., … Ala-Korpela, M. (2019). Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition [Journal Article]. PLoS Biol, 17(12), e3000572. https://doi.org/10.1371/journal.pbio.3000572
  361. Kettunen, J., Holmes, M. V., Allara, E., Anufrieva, O., Ohukainen, P., Oliver-Williams, C., Wang, Q., Tillin, T., Hughes, A. D., Kahonen, M., Lehtimaki, T., Viikari, J., Raitakari, O. T., Salomaa, V., Jarvelin, M. R., Perola, M., Smith, G. D., Chaturvedi, N., Danesh, J., … Ala-Korpela, M. (2020). Correction: Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition [Journal Article]. PLoS Biol, 18(3), e3000694. https://doi.org/10.1371/journal.pbio.3000694
  362. Khamis, R. Y., Hughes, A. D., Caga-Anan, M., Chang, C. L., Boyle, J. J., Kojima, C., Welsh, P., Sattar, N., Johns, M., Sever, P., Mayet, J., & Haskard, D. O. (2016). High Serum Immunoglobulin G and M Levels Predict Freedom From Adverse Cardiovascular Events in Hypertension: A Nested Case-Control Substudy of the Anglo-Scandinavian Cardiac Outcomes Trial [Journal Article]. EBioMedicine, 9, 372–380. https://doi.org/10.1016/j.ebiom.2016.06.012
  363. Khamis, R. Y., Johns, M., Thom, S., Mayet, J., McConnell, E., Stanton, A., Jeyapalan, S., Annon, S., Wrigley, S., Hughes, A., & Haskard, D. O. (2011). Igg Anti-Malonedialdehyde-Ldl Antibodies Are Associated with Low Risk of Cardiovascular Events in a Substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (Ascot), and Are Unrelated to Ldl, Crp Levels and Statin Treatment [Journal Article]. Heart, 97(20), 5–5. https://doi.org/10.1136/heartjnl-2011-300920b.9
  364. Khanolkar, A. R., Chaturvedi, N., Kuan, V., Davis, D., Hughes, A., Richards, M., Bann, D., & Patalay, P. (2021). Socioeconomic inequalities in prevalence and development of multimorbidity across adulthood: A longitudinal analysis of the MRC 1946 National Survey of Health and Development in the UK [Journal Article]. PLoS Med, 18(9), e1003775. https://doi.org/10.1371/journal.pmed.1003775
  365. King, E., Xu, X. Y., Hughes, A. D., Long, Q., Thom, S. A., & Parker, K. H. (2002). Quantification of the non-planarity of the human carotid bifurcation [Journal Article]. Biorheology, 39(3-4), 419–424. https://www.ncbi.nlm.nih.gov/pubmed/12122261
  366. King, L. A., Stanton, A. V., Sever, P. S., Thom, S. A., & Hughes, A. D. (1996). Arteriolar length-diameter (L:D) ratio: a geometric parameter of the retinal vasculature diagnostic of hypertension [Journal Article]. J Hum Hypertens, 10(6), 417–418. http://www.ncbi.nlm.nih.gov/pubmed/8872809
  367. Knoops, P. G., Biglino, G., Hughes, A. D., Parker, K. H., Xu, L., Schievano, S., & Torii, R. (2016). A Mock Circulatory System Incorporating a Compliant 3D-Printed Anatomical Model to Investigate Pulmonary Hemodynamics [Journal Article]. Artif Organs. https://doi.org/10.1111/aor.12809
  368. Kousera, C. A., Nijjer, S., Torii, R., Petraco, R., Sen, S., Foin, N., Hughes, A. D., Francis, D. P., Xu, X. Y., & Davies, J. E. (2014). Patient-specific coronary stenoses can be modeled using a combination of OCT and flow velocities to accurately predict hyperemic pressure gradients [Journal Article]. IEEE Trans Biomed Eng, 61(6), 1902–1913. https://doi.org/10.1109/TBME.2014.2310954
  369. Kox, M., Wijetunge, S., Pickkers, P., & Hughes, A. D. (2007). Inhibition of Src family tyrosine kinases prevents lipopolysaccharide-induced hyporeactivity in isolated rat tail arteries [Journal Article]. Vascul Pharmacol, 46(3), 195–200. https://doi.org/10.1016/j.vph.2006.10.004
  370. Kuh, D., Pierce, M., Adams, J., Deanfield, J., Ekelund, U., Friberg, P., Ghosh, A. K., Harwood, N., Hughes, A., Macfarlane, P. W., Mishra, G., Pellerin, D., Wong, A., Stephen, A. M., Richards, M., Hardy, R., scientific, N., & data collection, team. (2011). Cohort profile: updating the cohort profile for the MRC National Survey of Health and Development: a new clinic-based data collection for ageing research [Journal Article]. Int J Epidemiol, 40(1), e1–9. https://doi.org/10.1093/ije/dyq231
  371. Kukadia, S., Dehbi, H. M., Tillin, T., Coady, E., Chaturvedi, N., & Hughes, A. D. (2019). A Double-Blind Placebo-Controlled Crossover Study of the Effect of Beetroot Juice Containing Dietary Nitrate on Aortic and Brachial Blood Pressure Over 24 h [Journal Article]. Front Physiol, 10, 47. https://doi.org/10.3389/fphys.2019.00047
  372. Kun, A., Matchkov, V. V., Stankevicius, E., Nardi, A., Hughes, A. D., Kirkeby, H. J., Demnitz, J., & Simonsen, U. (2009). NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels, enhances erectile responses in rats [Journal Article]. Br J Pharmacol, 158(6), 1465–1476. https://doi.org/10.1111/j.1476-5381.2009.00404.x
  373. Kyriacou, A., Li Kam Wa, M. E., Pabari, P. A., Unsworth, B., Baruah, R., Willson, K., Peters, N. S., Kanagaratnam, P., Hughes, A. D., Mayet, J., Whinnett, Z. I., & Francis, D. P. (2013). A systematic approach to designing reliable VV optimization methodology: assessment of internal validity of echocardiographic, electrocardiographic and haemodynamic optimization of cardiac resynchronization therapy [Journal Article]. Int J Cardiol, 167(3), 954–964. https://doi.org/10.1016/j.ijcard.2012.03.086
  374. Kyriacou, A., Pabari, P. A., Mayet, J., Peters, N. S., Davies, D. W., Lim, P. B., Lefroy, D., Hughes, A. D., Kanagaratnam, P., Francis, D. P., & Whinnett, Z. I. (2014). Cardiac resynchronization therapy and AV optimization increase myocardial oxygen consumption, but increase cardiac function more than proportionally [Journal Article]. Int J Cardiol, 171(2), 144–152. https://doi.org/10.1016/j.ijcard.2013.10.026
  375. Kyriacou, A., Pabari, P. A., Whinnett, Z. I., Arri, S., Willson, K., Baruah, R., Stegemann, B., Mayet, J., Kanagaratnam, P., Hughes, A. D., & Francis, D. P. (2012). Fully automatable, reproducible, noninvasive simple plethysmographic optimization: proof of concept and potential for implantability [Journal Article]. Pacing Clin Electrophysiol, 35(8), 948–960. https://doi.org/10.1111/j.1540-8159.2012.03435.x
  376. Kyriacou, A., Rajkumar, C. A., Pabari, P. A., Sohaib, S. M. A., Willson, K., Peters, N. S., Lim, P. B., Kanagaratnam, P., Hughes, A. D., Mayet, J., Whinnett, Z. I., & Francis, D. P. (2018). Distinct impacts of heart rate and right atrial-pacing on left atrial mechanical activation and optimal AV delay in CRT [Journal Article]. Pacing Clin Electrophysiol. https://doi.org/10.1111/pace.13401
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  379. Lathe, J., Silverwood, R. J., Hughes, A. D., & Patalay, P. (2024). Examining how well economic evaluations capture the value of mental health [Journal Article]. Lancet Psychiatry, 11(3), 221–230. https://doi.org/10.1016/S2215-0366(23)00436-4
  380. Lawson, C. A., Moss, A. J., Arnold, J. R., Bagot, C., Banerjee, A., Berry, C., Greenwood, J., Hughes, A. D., Khunti, K., Mills, N. L., Neubauer, S., Raman, B., Sattar, N., Leavy, O. C., Richardson, M., Elneima, O., McAuley, H. J., Shikotra, A., Singapuri, A., … Group, P.-C. S. C. (2024). Long COVID and cardiovascular disease: a prospective cohort study [Journal Article]. Open Heart, 11(1), e002662. https://doi.org/10.1136/openhrt-2024-002662
  381. Leeuwis, A. E., Smith, L. A., Melbourne, A., Hughes, A. D., Richards, M., Prins, N. D., Sokolska, M., Atkinson, D., Tillin, T., Jager, H. R., Chaturvedi, N., van der Flier, W. M., & Barkhof, F. (2018). Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study [Journal Article]. Front Aging Neurosci, 10, 279. https://doi.org/10.3389/fnagi.2018.00279
  382. Leung, J., Wright, A., Cheshire, N., Thom, S. A., Hughes, A. D., & Xu, X. Y. (2004). Flow patterns and wall shear stresses in patient-specific models of the abdominal aortic aneurysm [Journal Article]. Stud Health Technol Inform, 103, 235–242. http://www.ncbi.nlm.nih.gov/pubmed/15747926
  383. Leung, J. H., Wright, A. R., Cheshire, N., Crane, J., Thom, S. A., Hughes, A. D., & Xu, Y. (2006). Fluid structure interaction of patient specific abdominal aortic aneurysms: a comparison with solid stress models [Journal Article]. Biomed Eng Online, 5, 33. https://doi.org/10.1186/1475-925X-5-33
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  386. Liu, D., Wood, N. B., Witt, N., Hughes, A. D., Thom, S. A., & Xu, X. Y. (2009). Computational analysis of oxygen transport in the retinal arterial network [Journal Article]. Curr Eye Res, 34(11), 945–956. https://doi.org/10.3109/02713680903230079
  387. Liu, D., Wood, N. B., Witt, N., Hughes, A. D., Thom, S. A., & Xu, X. Y. (2012). Assessment of energy requirement for the retinal arterial network in normal and hypertensive subjects [Journal Article]. J Biomech Eng, 134(1), 014501. https://doi.org/10.1115/1.4005529
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  393. Lymn, J. S., Gallagher, K. L., Clunn, G. F., Fexby, S. E., Patel, M. K., & Hughes, A. D. (2003). PDGF stimulates DNA synthesis in human vascular smooth muscle cells via a novel wortmannin-insensitive phosphatidylinositol 3-kinase [Journal Article]. FEBS Lett, 555(3), 591–596. https://doi.org/10.1016/S0014-5793(03)01350-4
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  395. Lymn, J. S., Patel, M. K., Clunn, G. F., Rao, S. J., Gallagher, K. L., & Hughes, A. D. (2002). Thrombospondin-1 differentially induces chemotaxis and DNA synthesis of human venous smooth muscle cells at the receptor-binding level [Journal Article]. J Cell Sci, 115(22), 4353–4360. https://doi.org/10.1242/jcs.00119
  396. Lymn, J. S., Rao, S. J., Clunn, G. F., Gallagher, K. L., O’Neil, C., Thompson, N. T., & Hughes, A. D. (1999). Phosphatidylinositol 3-kinase and focal adhesion kinase are early signals in the growth factor-like responses to thrombospondin-1 seen in human vascular smooth muscle [Journal Article]. Arterioscler Thromb Vasc Biol, 19(9), 2133–2140. https://doi.org/Doi 10.1161/01.Atv.19.9.2133
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  454. Negoita, M., Hughes, A. D., Parker, K. H., & Khir, A. W. (2018). A method for determining local pulse wave velocity in human ascending aorta from sequential ultrasound measurements of diameter and velocity [Journal Article]. Physiol Meas, 39(11), 114009. https://doi.org/10.1088/1361-6579/aae8a0
  455. Neumann, S., Parker, K. H., Hughes, A. D., & Biglino, G. (2024). A Systematic Review of Wave Speed and Wave Intensity Measures in the Human Carotid Arteries [Journal Article]. Artery Research, 30(1). https://doi.org/ARTN 12 10.1007/s44200-024-00058-4
  456. Nielsen, H., Thom, S. M., Hughes, A. D., Martin, G. N., Mulvany, M. J., & Sever, P. S. (1989). Postjunctional alpha 2-adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels. [Journal Article]. Br J Pharmacol, 97(3), 829–834. https://doi.org/10.1111/j.1476-5381.1989.tb12022.x
  457. Nijjer, S., Sen, S., da Cunha, R. P., Cuculi, F., Broyd, C., Foin, N., Foale, R., Malik, I., Mikhail, G., Sethi, A., Kaprielian, R., Baker, C., Hughes, A., Francis, D., Mayet, J., Kharbanda, R., Kharbanda, R., Di Mario, C., & Davies, J. (2013). Instantaneous Wave-Free Ratio (IFR) Can Detect Improvement in Coronary Haemodynamics after PCI [Journal Article]. Journal of the American College of Cardiology, 61(10), E1767–E1767. https://doi.org/10.1016/S0735-1097(13)61767-2
  458. Nijjer, S. S., Pabari, P., Stegemann, B., Palmieri, V., Freemantle, N., Hughes, A., & Francis, D. P. (2011). Prediction of Response to Biventricular Pacing from Dyssynchrony Indices: The Absolute Limit on Predictability, and Its Clinical Implications [Journal Article]. Heart, 97, A49–A50. https://doi.org/10.1136/heartjnl-2011-300198.85
  459. Nijjer, S. S., Pabari, P. A., Stegemann, B., Palmieri, V., Leyva, F., Linde, C., Freemantle, N., Davies, J. E., Hughes, A. D., & Francis, D. P. (2012). Erratum: The limit of plausibility for predictors of response: Application to biventricular pacing. (JACC: Cardiovascular Imaging (2012) 5 (1046-1065)) [Journal Article]. JACC: Cardiovascular Imaging, 5(11). https://doi.org/10.1016/j.jcmg.2012.10.003
  460. Nijjer, S. S., Pabari, P. A., Stegemann, B., Palmieri, V., Leyva, F., Linde, C., Freemantle, N., Davies, J. E., Hughes, A. D., & Francis, D. P. (2012). The limit of plausibility for predictors of response: application to biventricular pacing [Journal Article]. JACC Cardiovasc Imaging, 5(10), 1046–1065. https://doi.org/10.1016/j.jcmg.2012.07.010
  461. Nijjer, S. S., Petraco, R., van de Hoef, T. P., Sen, S., van Lavieren, M. A., Foale, R. A., Meuwissen, M., Broyd, C., Echavarria-Pinto, M., Al-Lamee, R., Foin, N., Sethi, A., Malik, I. S., Mikhail, G. W., Hughes, A. D., Mayet, J., Francis, D. P., Di Mario, C., Escaned, J., … Davies, J. E. (2015). Change in coronary blood flow after percutaneous coronary intervention in relation to baseline lesion physiology: results of the JUSTIFY-PCI study [Journal Article]. Circ Cardiovasc Interv, 8(6), e001715. https://doi.org/10.1161/CIRCINTERVENTIONS.114.001715
  462. Nijjer, S. S., Sen, S., Petraco, R., Cuculi, F., Broyd, C., Foin, N., Foale, R., Malik, I., Mikhail, G., Sethi, A. S., Kaprielian, R. R., Baker, C. S., Hughes, A. D., Mayet, J., Kharbanda, R. K., Di Mario, C., & Davies, J. E. (2013). Instantaneous Wave-free Ratio Can Assess Improvement in Coronary Haemodynamics After Percutaneous Intervention. [Journal Article]. Am J Cardiol, 111(7), 100b–100b. https://doi.org/10.1016/j.amjcard.2013.01.251
  463. Nijjer, S. S., Sen, S., Petraco, R., Escaned, J., Echavarria-Pinto, M., Broyd, C., Al-Lamee, R., Foin, N., Foale, R. A., Malik, I. S., Mikhail, G. W., Sethi, A. S., Al-Bustami, M., Kaprielian, R. R., Khan, M. A., Baker, C. S., Bellamy, M. F., Hughes, A. D., Mayet, J., … Davies, J. E. (2014). Pre-angioplasty instantaneous wave-free ratio pullback provides virtual intervention and predicts hemodynamic outcome for serial lesions and diffuse coronary artery disease [Journal Article]. JACC Cardiovasc Interv, 7(12), 1386–1396. https://doi.org/10.1016/j.jcin.2014.06.015
  464. Nijjer, S. S., Sen, S., Petraco, R., Sachdeva, R., Cuculi, F., Escaned, J., Broyd, C., Foin, N., Hadjiloizou, N., Foale, R. A., Malik, I., Mikhail, G. W., Sethi, A. S., Al-Bustami, M., Kaprielian, R. R., Khan, M. A., Baker, C. S., Bellamy, M. F., Hughes, A. D., … Davies, J. E. (2013). Improvement in coronary haemodynamics after percutaneous coronary intervention: assessment using instantaneous wave-free ratio [Journal Article]. Heart, 99(23), 1740–1748. https://doi.org/10.1136/heartjnl-2013-304387
  465. Norris, T., Mansukoski, L., Gilthorpe, M. S., Hamer, M., Hardy, R., Howe, L. D., Hughes, A. D., Li, L., O’Donnell, E., Ong, K. K., Ploubidis, G. B., Silverwood, R. J., Viner, R. M., & Johnson, W. (2021). Distinct Body Mass Index Trajectories to Young-Adulthood Obesity and Their Different Cardiometabolic Consequences [Journal Article]. Arterioscler Thromb Vasc Biol, 41(4), 1580–1593. https://doi.org/10.1161/ATVBAHA.120.315782
  466. O’Hartaigh, B., Gill, T. M., Shah, I., Hughes, A. D., Deanfield, J. E., Kuh, D., & Hardy, R. (2014). Association between resting heart rate across the life course and all-cause mortality: longitudinal findings from the Medical Research Council (MRC) National Survey of Health and Development (NSHD) [Journal Article]. J Epidemiol Community Health, 68(9), 883–889. https://doi.org/10.1136/jech-2014-203940
  467. O’Keeffe, L. M., Howe, L. D., Fraser, A., Hughes, A. D., Wade, K. H., Anderson, E. L., Lawlor, D. A., Erzurumluoglu, A. M., Davey-Smith, G., Rodriguez, S., & Stergiakouli, E. (2018). Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence [Journal Article]. Atherosclerosis, 274, 94–103. https://doi.org/10.1016/j.atherosclerosis.2018.04.027
  468. O’Nunain, K., Park, C., Urquijo, H., Leyden, G. M., Hughes, A. D., Davey Smith, G., & Richardson, T. G. (2022). A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure [Journal Article]. PLoS Biol, 20(6), e3001656. https://doi.org/10.1371/journal.pbio.3001656
  469. Orini, M., Luis Flores, J., Chaturvedi, N., & Hughes, A. (2023). Wearable-Derived Long-Term Heart Rate Variability Predicts Major Adverse Cardiovascular Events in Middle Aged Individuals without Previous Cardiovascular Disease [Conference Paper]. https://doi.org/10.22489/CinC.2023.177
  470. Orini, M., van Duijvenboden, S., Young, W. J., Ramirez, J., Jones, A. R., Hughes, A. D., Tinker, A., Munroe, P. B., & Lambiase, P. D. (2023). Long-term association of ultra-short heart rate variability with cardiovascular events [Journal Article]. Sci Rep, 13(1), 18966. https://doi.org/10.1038/s41598-023-45988-2
  471. Pabari, P. A., Kyriacou, A., Moraldo, M., Hughes, A. D., Mayet, J., & Francis, D. P. (2011). Optimization of VV Delay of CRT Is More Reproducible Using Peak Velocities Than Using Velocity Time Integral, as Well as Being Quicker [Journal Article]. Journal of the American College of Cardiology, 57(14), E802. https://doi.org/10.1016/s0735-1097(11)60802-4
  472. Pabari, P. A., Kyriacou, A., Moraldo, M., Manisty, C., Hughes, A. D., Mayet, J., & Francis, D. P. (2011). Optimisation of VV delay of CRT is more reproducible using peak velocities than using velocity time integral, as well as being quicker [Journal Article]. Heart, 97, A50–A51. https://doi.org/10.1136/heartjnl-2011-300198.87
  473. Pabari, P. A., Kyriacou, A., Moraldo, M., Unsworth, B., Sutaria, N., Mayet, J., Hughes, A. D., & Francis, D. P. (2011). CRT Optimisation: Improving Echocardiographic Techniques by Accommodating Biological Variability within Different Echocardiographic Parameters [Journal Article]. Heart, 97, A66–A67. https://doi.org/10.1136/heartjnl-2011-300198.116
  474. Pabari, P. A., Kyriacou, A., Wright, I., Hughes, A. D., Mayet, J., Whinnett, Z. I., Francis, D. P., & Manisty, C. H. (2012). Simultaneous Invasive Pressure and Flow Measurements during Atrioventricular Delay Improvement Reveal a Compensatory Peripheral Vasodilator Response Which Attenuates the Initial Blood Pressure Increment: Implications for the Design of Optimisation Protocols [Journal Article]. Heart, 98, A5–A6. https://doi.org/10.1136/heartjnl-2012-301877b.4
  475. Pabari, P. A., Moraldo, M., Hughes, A. D., Mayet, J., Kyriacou, A., Francis, D. P., & Manisty, C. H. (2012). 003 Validating markers of mechanical dyssynchrony by experimental manipulation of interventricular timings: what is needed to make them a reasonable prospect for cardiac resynchronisation therapy selection? [Journal Article]. Heart, 98(Suppl 1), A5.1. https://doi.org/10.1136/heartjnl-2012-301877b.3
  476. Pabari, P. A., Willson, K., Stegemann, B., van Geldorp, I. E., Kyriacou, A., Moraldo, M., Mayet, J., Hughes, A. D., & Francis, D. P. (2011). When is an optimization not an optimization? Evaluation of clinical implications of information content (signal-to-noise ratio) in optimization of cardiac resynchronization therapy, and how to measure and maximize it [Journal Article]. Heart Fail Rev, 16(3), 277–290. https://doi.org/10.1007/s10741-010-9203-5
  477. Page, C. M., Khir, A. W., Hughes, A. D., Chung, R., & Henein, M. Y. (2010). Normal asynchrony of left ventricular long and short axes: their relationship with aortic hemodynamics [Journal Article]. Int J Cardiol, 142(2), 166–171. https://doi.org/10.1016/j.ijcard.2008.12.188
  478. Palombo, C., Kozakova, M., Morizzo, C., Losso, L., Pagani, M., Salvi, P., Parker, K. H., & Hughes, A. D. (2022). Carotid Reservoir Pressure Decrease After Prolonged Head Down Tilt Bed Rest in Young Healthy Subjects Is Associated With Reduction in Left Ventricular Ejection Time and Diastolic Length [Journal Article]. Front Physiol, 13, 866045. https://doi.org/10.3389/fphys.2022.866045
  479. Palombo, C., Kozakova, M., Morizzo, C., Losso, L., Pagani, M., Salvi, P., Parker, K. H., & Hughes, A. D. (2022). Corrigendum: Carotid reservoir pressure decrease after prolonged head down tilt bed rest in young healthy subjects is associated with reduction in left ventricular ejection time and diastolic length [Journal Article]. Front Physiol, 13, 990346. https://doi.org/10.3389/fphys.2022.990346
  480. Park, C., Bathula, R., Shore, A. C., Tillin, T., Strain, W. D., Chaturvedi, N., & Hughes, A. D. (2012). Impaired post-ischaemic microvascular hyperaemia in Indian Asians is unexplained by diabetes or other cardiovascular risk factors [Journal Article]. Atherosclerosis, 221(2), 503–507. https://doi.org/10.1016/j.atherosclerosis.2011.11.025
  481. Park, C., Fraser, A., Howe, L. D., Jones, S., Davey Smith, G., Lawlor, D. A., Chaturvedi, N., & Hughes, A. D. (2018). Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance [Journal Article]. Hypertension, 72(5), 1103–1108. https://doi.org/10.1161/HYPERTENSIONAHA.118.11925
  482. Park, C., Jones, S., Taylor, H., Howe, L., Fraser, A., Chaturvedi, N., & Hughes, A. (2021). Selected Abstracts from Artery 21: Thursday 21 - Saturday 23 October 2021, Hopital Europeen Georges-Pompidou, Paris, France [Journal Article]. Artery Res, 27, 1–36. https://doi.org/10.1007/s44200-021-00008-4
  483. Park, C. M., Hughes, A. D., Henein, M. Y., & Khir, A. W. (2020). Mechanisms of Aortic Flow Deceleration and the Effect of Wave Reflection on Left Ventricular Function [Journal Article]. Front Physiol, 11, 578701. https://doi.org/10.3389/fphys.2020.578701
  484. Park, C. M., Korolkova, O., Davies, J. E., Parker, K. H., Siggers, J. H., March, K., Tillin, T., Chaturvedi, N., & Hughes, A. D. (2014). Arterial pressure: agreement between a brachial cuff-based device and radial tonometry [Journal Article]. J Hypertens, 32(4), 865–872. https://doi.org/10.1097/HJH.0000000000000082
  485. Park, C. M., March, K., Ghosh, A. K., Jones, S., Coady, E., Tuson, C., Francis, D., Mayet, J., Tillin, T., Chaturvedi, N., & Hughes, A. D. (2013). Left-ventricular structure in the Southall And Brent REvisited (SABRE) study: explaining ethnic differences [Journal Article]. Hypertension, 61(5), 1014–1020. https://doi.org/10.1161/HYPERTENSIONAHA.111.00610
  486. Park, C. M., March, K., Tillin, T., Hughes, A. D., & Chaturvedi, N. (2013). Are ethnic differences in central pulse pressure explained by hyperglycaemia? [Journal Article]. Diabetic Medicine, 30, 22. https://onlinelibrary.wiley.com/doi/pdf/10.1111/dme.12090_13
  487. Park, C. M., March, K., Williams, S., Kukadia, S., Ghosh, A. K., Jones, S., Tillin, T., Chaturvedi, N., & Hughes, A. D. (2013). Feasibility and reproducibility of left ventricular rotation by speckle tracking echocardiography in elderly individuals and the impact of different software [Journal Article]. PLoS One, 8(9), e75098. https://doi.org/10.1371/journal.pone.0075098
  488. Park, C. M., Tillin, T., March, K., Chaturvedi, N., & Hughes, A. D. (2013). Ethnic differences in central haemodynamics and central arterial stiffness [Journal Article]. Journal of Human Hypertension, 27(10), 639. https://doi.org/10.1038/jhh.2013.72
  489. Park, C. M., Tillin, T., March, K., Ghosh, A. K., Jones, S., Wright, A., Heasman, J., Francis, D., Sattar, N., Mayet, J., Chaturvedi, N., & Hughes, A. D. (2014). Hyperglycemia has a greater impact on left ventricle function in South Asians than in Europeans [Journal Article]. Diabetes Care, 37(4), 1124–1131. https://doi.org/10.2337/dc13-1864
  490. Park, C. M., Tillin, T., March, K., Jones, S., Whincup, P. H., Mayet, J., Chaturvedi, N., & Hughes, A. D. (2016). Adverse effect of diabetes and hyperglycaemia on arterial stiffness in Europeans, South Asians, and African Caribbeans in the SABRE study [Journal Article]. J Hypertens, 34(2), 282–289. https://doi.org/10.1097/HJH.0000000000000789
  491. Park, C. M., Williams, E. D., Chaturvedi, N., Tillin, T., Stewart, R. J., Richards, M., Shibata, D., Mayet, J., & Hughes, A. D. (2017). Associations Between Left Ventricular Dysfunction and Brain Structure and Function: Findings From the SABRE (Southall and Brent Revisited) Study [Journal Article]. J Am Heart Assoc, 6(4). https://doi.org/10.1161/JAHA.116.004898
  492. Parker, K. H., & Hughes, A. D. (2024). The theoretical basis of reservoir pressure in arteries [Journal Article]. ArXiv, 2404.10806v1.
  493. Parker, R. M. A., Leckie, G., Goldstein, H., Howe, L. D., Heron, J., Hughes, A. D., Phillippo, D. M., & Tilling, K. (2021). Joint Modeling of Individual Trajectories, Within-Individual Variability, and a Later Outcome: Systolic Blood Pressure Through Childhood and Left Ventricular Mass in Early Adulthood [Journal Article]. Am J Epidemiol, 190(4), 652–662. https://doi.org/10.1093/aje/kwaa224
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  496. Parkinson, N. A., Wijetunge, S., & Hughes, A. D. (1994). Alpha(2)-Adrenoceptor Activation Increases Voltage-Dependent Calcium-Channel Currents in Human Arterial Smooth-Muscle Cells [Journal Article]. British Journal of Pharmacology, 112, U111–U111. ://WOS:A1994NE99700217 https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1994.tb13038.x</span></li>
  497. Patel, K. P., Scully, P. R., Nitsche, C., Kammerlander, A. A., Joy, G., Thornton, G., Hughes, R., Williams, S., Tillin, T., Captur, G., Chacko, L., Kelion, A., Sabharwal, N., Newton, J. D., Kennon, S., Ozkor, M., Mullen, M., Hawkins, P. N., Gillmore, J. D., … Moon, J. C. (2022). Impact of afterload and infiltration on coexisting aortic stenosis and transthyretin amyloidosis [Journal Article]. Heart, 108(1), 67–72. https://doi.org/10.1136/heartjnl-2021-319922
  498. Patel, M. K., Betteridge, L. J., Hughes, A. D., Clunn, G. F., Schachter, M., Shaw, R. J., & Sever, P. S. (1996). Effect of angiotensin II on the expression of the early growth response gene c-fos and DNA synthesis in human vascular smooth muscle cells [Journal Article]. Journal of Hypertension, 14(3), 341–347. https://doi.org/Doi 10.1097/00004872-199603000-00011
  499. Patel, M. K., Clunn, G. F., Lymn, J. S., Austin, O., & Hughes, A. D. (2005). Effect of serum withdrawal on the contribution of L-type calcium channels (CaV1.2) to intracellular Ca2+ responses and chemotaxis in cultured human vascular smooth muscle cells [Journal Article]. Br J Pharmacol, 145(6), 811–817. https://doi.org/10.1038/sj.bjp.0706237
  500. Patel, M. K., Clunn, G. F., Lymn, J. S., & Hughes, A. D. (1996). Thrombospondin-1 induces DNA synthesis and migration in human vascular smooth muscle cells [Journal Article]. Biochem Soc Trans, 24(3), 446S. https://doi.org/10.1042/bst024446s
  501. Patel, M. K., Lymn, J. S., Clunn, G. F., & Hughes, A. D. (1997). Thrombospondin-1 is a potent mitogen and chemoattractant for human vascular smooth muscle cells [Journal Article]. Arterioscler Thromb Vasc Biol, 17(10), 2107–2114. http://www.ncbi.nlm.nih.gov/pubmed/9351379
  502. Patel, M. K., Mulloy, B., Gallagher, K. L., O’Brien, L., & Hughes, A. D. (2002). The antimitogenic action of the sulphated polysaccharide fucoidan differs from heparin in human vascular smooth muscle cells [Journal Article]. Thromb Haemost, 87(1), 149–154. https://www.ncbi.nlm.nih.gov/pubmed/11848445
  503. Patel, M. K., Refson, J. S., Schachter, M., & Hughes, A. D. (1999). Characterization of [3H]-heparin binding in human vascular smooth muscle cells and its relationship to the inhibition of DNA synthesis [Journal Article]. Br J Pharmacol, 127(2), 361–368. https://doi.org/10.1038/sj.bjp.0702559
  504. Patel, S., Bathula, R., Page, C., Tillin, T., Chaturvedi, N., Godsland, I., Potter, J., Panerai, R. B., & Hughes, A. D. (2007). Cerebrovascular effects of an oral glucose tolerance test [Journal Article]. Hypertension, 50(4), 800.
  505. Patel, S., Lawlor, D. A., Ferreira, D. L., Hughes, A. D., Chaturvedi, N., Callaway, M., Day, C., Sattar, N., & Fraser, A. (2015). The association of nonalcoholic fatty liver disease with central and peripheral blood pressure in adolescence: findings from a cross-sectional study [Journal Article]. J Hypertens, 33(3), 546–552; discussion 553. https://doi.org/10.1097/HJH.0000000000000445
  506. Peterzan, M. A., Hardy, R., Chaturvedi, N., & Hughes, A. D. (2012). Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate [Journal Article]. Hypertension, 59(6), 1104–1109. https://doi.org/10.1161/HYPERTENSIONAHA.111.190637
  507. Petraco, R., Escaned, J., Sen, S., Nijjer, S., Asrress, K. N., Echavarria-Pinto, M., Lockie, T., Khawaja, M. Z., Cuevas, C., Foin, N., Broyd, C., Foale, R. A., Hadjiloizou, N., Malik, I. S., Mikhail, G. W., Sethi, A., Kaprielian, R., Baker, C. S., Lefroy, D., … Davies, J. E. (2013). Classification performance of instantaneous wave-free ratio (iFR) and fractional flow reserve in a clinical population of intermediate coronary stenoses: results of the ADVISE registry [Journal Article]. EuroIntervention, 9(1), 91–101. https://doi.org/10.4244/EIJV9I1A14
  508. Petraco, R., Park, J. J., Sen, S., Nijjer, S., Malik, I., Pinto, M., Asrress, K., Nam, C., Foale, R., Sethi, A., Mikhail, G., Baker, C., Lefroy, D., Bellamy, M., Al-Bustami, M., Khan, M., Gonzalo, N., Hughes, A., Francis, D., … Davies, J. (2013). Hybrid Ifr-FFR Decision-Making Strategy: Implications for Enhancing Universal Adoption of Physiology-Guided Coronary Revascularization. [Journal Article]. Am J Cardiol, 111(7), 54b–54b. https://doi.org/10.1016/j.amjcard.2013.01.138
  509. Petraco, R., Park, J. J., Sen, S., Nijjer, S. S., Malik, I. S., Echavarria-Pinto, M., Asrress, K. N., Nam, C. W., Macias, E., Foale, R. A., Sethi, A., Mikhail, G. W., Kaprielian, R., Baker, C. S., Lefroy, D., Bellamy, M., Al-Bustami, M., Khan, M. A., Gonzalo, N., … Davies, J. E. (2013). Hybrid iFR-FFR decision-making strategy: implications for enhancing universal adoption of physiology-guided coronary revascularisation [Journal Article]. EuroIntervention, 8(10), 1157–1165. https://doi.org/10.4244/EIJV8I10A179
  510. Petraco, R., van de Hoef, T. P., Nijjer, S., Sen, S., van Lavieren, M. A., Foale, R. A., Meuwissen, M., Broyd, C., Echavarria-Pinto, M., Foin, N., Malik, I. S., Mikhail, G. W., Hughes, A. D., Francis, D. P., Mayet, J., Di Mario, C., Escaned, J., Piek, J. J., & Davies, J. E. (2014). Baseline instantaneous wave-free ratio as a pressure-only estimation of underlying coronary flow reserve: results of the JUSTIFY-CFR Study (Joined Coronary Pressure and Flow Analysis to Determine Diagnostic Characteristics of Basal and Hyperemic Indices of Functional Lesion Severity-Coronary Flow Reserve) [Journal Article]. Circ Cardiovasc Interv, 7(4), 492–502. https://doi.org/10.1161/CIRCINTERVENTIONS.113.000926
  511. Petrie, J. R., Chaturvedi, N., Ford, I., Brouwers, M., Greenlaw, N., Tillin, T., Hramiak, I., Hughes, A. D., Jenkins, A. J., Klein, B. E. K., Klein, R., Ooi, T. C., Rossing, P., Stehouwer, C. D. A., Sattar, N., & Colhoun, H. M. (2017). Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial [Journal Article]. Lancet Diabetes Endocrinol, 5(8), 597–609. https://doi.org/10.1016/s2213-8587(17)30194-8
  512. Petrie, J. R., Chaturvedi, N., Ford, I., Hramiak, I., Hughes, A. D., Jenkins, A. J., B, E. K., Klein, R., Ooi, T. C., Rossing, P., Sattar, N., Stehouwer, C. D., Colhoun, H. M., & Team, R. T. (2017). Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial [Journal Article]. Diabetes Obes Metab, 19(4), 509–516. https://doi.org/10.1111/dom.12840
  513. Pickkers, P., Dormans, T. P., Russel, F. G., Hughes, A. D., Thien, T., Schaper, N., & Smits, P. (1997). Direct vascular effects of furosemide in humans [Journal Article]. Circulation, 96(6), 1847–1852. https://www.ncbi.nlm.nih.gov/pubmed/9323071
  514. Pickkers, P., Garcha, R. S., Schachter, M., Smits, P., & Hughes, A. D. (1999). Inhibition of carbonic anhydrase accounts for the direct vascular effects of hydrochlorothiazide [Journal Article]. Hypertension, 33(4), 1043–1048. https://doi.org/10.1161/01.HYP.33.4.1043
  515. Pickkers, P., & Hughes, A. D. (1995). The Action of Hydrochlorothiazide on Force and Intracellular Ca2+ in Guinea-Pig Isolated Mesenteric Small Arteries [Journal Article]. British Journal of Pharmacology, 114, P98–P98. ://WOS:A1995QW12800098 https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1995.tb14917.x</span></li>
  516. Pickkers, P., & Hughes, A. D. (1995). Relaxation and decrease in [Ca2+]i by hydrochlorothiazide in guinea-pig isolated mesenteric arteries [Journal Article]. Br J Pharmacol, 114(3), 703–707. https://doi.org/10.1111/j.1476-5381.1995.tb17195.x
  517. Pickkers, P., Hughes, A. D., Russel, F. G. M., Thien, T., & Smits, P. (2001). In vivo evidence for K-Ca channel opening properties of acetazolamide in the human vasculature [Journal Article]. Br J Pharmacol, 132(2), 443–450. https://doi.org/10.1038/sj.bjp.0703825
  518. Pickkers, P., Hughes, A. D., Russel, F. G., Thien, T., & Smits, P. (2001). In vivo evidence for K(Ca) channel opening properties of acetazolamide in the human vasculature [Journal Article]. Br J Pharmacol, 132(2), 443–450. https://doi.org/10.1038/sj.bjp.0703825
  519. Pickkers, P., Hughes, A. D., Russel, F. G. M., Thien, T., & Smits, P. (1998). Thiazide-induced vasodilation in humans is mediated by potassium channel activation [Journal Article]. Hypertension, 32(6), 1071–1076. https://doi.org/Doi 10.1161/01.Hyp.32.6.1071
  520. Pickkers, P., Russel, F. G., Thien, T., Hughes, A. D., & Smits, P. (2003). Only weak vasorelaxant properties of loop diuretics in isolated resistance arteries from man, rat and guinea pig [Journal Article]. Eur J Pharmacol, 466(3), 281–287. https://doi.org/10.1016/S0014-2999(03)01536-X
  521. Pickkers, P., Russel, F. G. M., Hughes, A. D., Thien, T., & Smits, P. (1995). Hydrochlorothiazide exerts no direct vasoactivity in the human forearm [Journal Article]. J Hypertens, 13(12), 1833–1836. ://WOS:A1995TP45000061</span></li>
  522. Pickkers, P., Schachter, M., Hughes, A. D., Feher, M. D., & Sever, P. S. (1996). Thiazide-induced hyperglycaemia: a role for calcium-activated potassium channels? [Journal Article]. Diabetologia, 39(7), 861–864. http://www.ncbi.nlm.nih.gov/pubmed/8817113
  523. Pickkers, P., Schachter, M., Sever, P. S., & Hughes, A. D. (1995). Do K-Ca Channels and Carbonic-Anhydrase Play a Role in Thiazide-Induced Hyperglycemia [Journal Article]. Journal of Human Hypertension, 9(8), 691–693. ://WOS:A1995RP56100022</span></li>
  524. Pickkers, P., van Beek, M., Hughes, A. D., Russel, F. G., Thien, T., & Smits, P. (1999). Presence and mechanism of direct vascular effects of amiloride in humans [Journal Article]. J Cardiovasc Pharmacol, 34(3), 388–393. https://doi.org/10.1097/00005344-199909000-00011
  525. Picone, D. S., Bui, T. V., Schultz, M. G., Otahal, P., Hughes, A. D., Black, J. A., Westerhof, B. E., Chen, C. H., Liang, F., Pucci, G., Cheng, H. M., Adams, H., Wang, J. G., Dwyer, N. B., Roberts-Thomson, P., Goupil, R., Paleri, S., Eaves, S. W., Peng, X., & Sharman, J. E. (2025). Systolic BP Amplification: Systematic Review and Individual Participant Meta-Analysis [Journal Article]. Hypertension, 82(9), 1460–1468. https://doi.org/10.1161/HYPERTENSIONAHA.124.24483
  526. Picone, D. S., Schultz, M. G., Armstrong, M. K., Black, J. A., Bos, W. J. W., Chen, C. H., Cheng, H. M., Cremer, A., Dwyer, N., Hughes, A. D., Kim, H. L., Lacy, P. S., Laugesen, E., Liang, F., Ohte, N., Okada, S., Omboni, S., Ott, C., Pereira, T., … Invasive Blood Pressure, C. (2021). Identifying Isolated Systolic Hypertension From Upper-Arm Cuff Blood Pressure Compared With Invasive Measurements [Journal Article]. Hypertension, 77(2), 632–639. https://doi.org/10.1161/HYPERTENSIONAHA.120.16109
  527. Picone, D. S., Schultz, M. G., Hughes, A. D., & Sharman, J. E. (2020). Cuff Under Pressure for Greater Accuracy [Journal Article]. Curr Hypertens Rep, 22(11), 93. https://doi.org/10.1007/s11906-020-01103-8
  528. Picone, D. S., Schultz, M. G., Otahal, P., Aakhus, S., Al-Jumaily, A. M., Black, J. A., Bos, W. J., Chambers, J. B., Chen, C. H., Cheng, H. M., Cremer, A., Davies, J. E., Dwyer, N., Gould, B. A., Hughes, A. D., Lacy, P. S., Laugesen, E., Liang, F., Melamed, R., … Sharman, J. E. (2017). Accuracy of Cuff-Measured Blood Pressure: Systematic Reviews and Meta-Analyses [Journal Article]. J Am Coll Cardiol, 70(5), 572–586. https://doi.org/10.1016/j.jacc.2017.05.064
  529. Picone, D. S., Schultz, M. G., Otahal, P., Black, J. A., Bos, W. J., Chen, C. H., Cheng, H. M., Cremer, A., Dwyer, N., Fonseca, R., Hughes, A. D., Kim, H. L., Lacy, P. S., Laugesen, E., Ohte, N., Omboni, S., Ott, C., Pereira, T., Pucci, G., … Invasive Blood Pressure, C. (2020). Influence of Age on Upper Arm Cuff Blood Pressure Measurement [Journal Article]. Hypertension, 75(3), 844–850. https://doi.org/10.1161/HYPERTENSIONAHA.119.13973
  530. Picone, D. S., Stoneman, E., Cremer, A., Schultz, M. G., Otahal, P., Hughes, A. D., Black, J. A., Bos, W. J., Chen, C. H., Cheng, H. M., Dwyer, N., Lacy, P., Laugesen, E., Liang, F., Kim, H. L., Ohte, N., Okada, S., Omboni, S., Ott, C., … Sharman, J. E. (2023). Sex Differences in Blood Pressure and Potential Implications for Cardiovascular Risk Management [Journal Article]. Hypertension, 80(2), 316–324. https://doi.org/10.1161/HYPERTENSIONAHA.122.19693
  531. Prabhakaran, D., Chandrasekaran, A. M., Singh, K., Mohan, B., Chattopadhyay, K., Chadha, D. S., Negi, P. C., Bhat, P., Sadananda, K. S., Ajay, V. S., Singh, K., Praveen, P. A., Devarajan, R., Kondal, D., Soni, D., Mallinson, P., Manchanda, S. C., Madan, K., Hughes, A. D., … Yoga-CaRe Trial, I. (2020). Yoga-Based Cardiac Rehabilitation After Acute Myocardial Infarction: A Randomized Trial [Journal Article]. J Am Coll Cardiol, 75(13), 1551–1561. https://doi.org/10.1016/j.jacc.2020.01.050
  532. Pratsinis, H., Demoliou-Mason, C., Hughes, A., Kletsas, D., Toussaint, O., Osiewacz, H. D., Lithgow, G. J., & Brack, C. (2000). A novel in vitro model of conditionally immortalized human vascular smooth muscle cells - A tool for aging studies [Book Section]. In Molecular and Cellular Gerontology (Vol. 908, pp. 321–323). http://onlinelibrary.wiley.com/store/10.1111/j.1749-6632.2000.tb06664.x/asset/j.1749-6632.2000.tb06664.x.pdf?v=1&t=ivsg0q7m&s=9f6e799575b4485443c9dfdedef5baa83fea0799
  533. Puntmann, V., Nagel, E., Hughes, A. D., Gebker, R., Gaddum, N., Mirelis, J., Jahnke, C., Schnackenburg, B., Fleck, E., & Paetsch, I. (2011). Myocardial deformation at rest and stress and relationship with aortic stiffness are gender-specific: a dobutamine-stress magnetic resonance imaging study [Journal Article]. European Heart Journal, 32, 10. ://WOS:000208702701028 https://watermark.silverchair.com/ehq338.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAbswggG3BgkqhkiG9w0BBwagggGoMIIBpAIBADCCAZ0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMGnJxoUdX97asJ8jAAgEQgIIBbpCwCFyxmMLHutDhyLECEmAcA07pSWfXMC80sf0pRzalVs6k6woOzdGhmcQoqWMpt5ueP8gxHpizz4QX8OXEaOcdjenQOUE1YQ32ss_tLA2YRNoQsiAmaT8vskXpceWFHGZVDA3up1g8FcjjnWfvz9SZaiEAUtQCL-eii5LE1xMkhdMRwUoFNaNR_TK1AyQv7mJ-595KtHc5qe7P0p_s7tRuoou1Dx8H2uiZ-eGX9bx-xsqghen-v0m3OrNo3vvvauteNCJ39A2l-OSsn4XgrmYaNG-lS1LccACl4LoctKS6zZquuJ1W5WQJW4DnGWGvMC_Aedr7WlNjxjkIk4c84Ry1qQtnS1nxigD96DqOACeAmBImY8H0dkMEP3ZhThRIqEL3XaOJXLKhQTb3wKSQlP5h3ijm0IlJ0pEuLCT-kFwznKy2W0tGIKzq00ehwpaGSg40ZKXyrhOETFT9cQqlHRG4CQ6ncOVcgIjjDeR55g</span></li>
  534. Puntmann, V. O., Nagel, E., Hughes, A. D., Gebker, R., Gaddum, N., Chowienczyk, P., Jahnke, C., Mirelis, J., Schnackenburg, B., Paetsch, I., & Fleck, E. (2012). Gender-specific differences in myocardial deformation and aortic stiffness at rest and dobutamine stress [Journal Article]. Hypertension, 59(3), 712–718. https://doi.org/10.1161/HYPERTENSIONAHA.111.183335
  535. Rahman, A., Hughes, A., Matchkov, V., Nilsson, H., & Aalkjaer, C. (2007). Antiphase oscillations of endothelium and smooth muscle [Ca2+]i in vasomotion of rat mesenteric small arteries [Journal Article]. Cell Calcium, 42(6), 536–547. https://doi.org/10.1016/j.ceca.2007.01.007
  536. Rajput, S., Jamieson, A., Chaturvedi, N., Hughes, A., & Orini, M. (2023). Assessment of Consumer-grade Wearable Devices to Track Sleep in Healthy Individuals in Free-living Conditions [Conference Paper]. https://doi.org/10.22489/CinC.2023.234
  537. Raphael, C. E., Cooper, R., Parker, K. H., Collinson, J., Vassiliou, V., Pennell, D. J., de Silva, R., Hsu, L. Y., Greve, A. M., Nijjer, S., Broyd, C., Ali, A., Keegan, J., Francis, D. P., Davies, J. E., Hughes, A. D., Arai, A., Frenneaux, M., Stables, R. H., … Prasad, S. K. (2016). Mechanisms of Myocardial Ischemia in Hypertrophic Cardiomyopathy: Insights From Wave Intensity Analysis and Magnetic Resonance [Journal Article]. J Am Coll Cardiol, 68(15), 1651–1660. https://doi.org/10.1016/j.jacc.2016.07.751
  538. Raphael, C. E., Keegan, J., Parker, K. H., Simpson, R., Collinson, J., Vassiliou, V., Wage, R., Drivas, P., Strain, S., Cooper, R., de Silva, R., Stables, R. H., Di Mario, C., Frenneaux, M., Pennell, D. J., Davies, J. E., Hughes, A. D., Firmin, D., & Prasad, S. K. (2016). Feasibility of cardiovascular magnetic resonance derived coronary wave intensity analysis [Journal Article]. J Cardiovasc Magn Reson, 18(1), 93. https://doi.org/10.1186/s12968-016-0312-8
  539. Raphael, C. E., Kyriacou, A., Jones, S., Pabari, P., Cole, G., Baruah, R., Hughes, A. D., & Francis, D. P. (2013). Multinational evaluation of the interpretability of the iterative method of optimisation of AV delay for CRT [Journal Article]. Int J Cardiol, 168(1), 407–413. https://doi.org/10.1016/j.ijcard.2012.09.097
  540. Ratneswaren, A., Wu, T., Kaura, A., Wasan, D., Rostamian, S., Sharp, A., Poulter, N. R., Sever, P. S., Stanton, A., Thom, S., Francis, D., Hughes, A. D., Shah, A. S., & Mayet, J. (2025). Tissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study [Journal Article]. Open Heart, 12(1), e002795. https://doi.org/10.1136/openhrt-2024-002795
  541. Redman, D., Thom, S. A., Hughes, A. D., Hasan, S., & Sever, P. S. (1985). Human vasodilator responses to a dopamine agonist: possible mechanisms [Journal Article]. J Hypertens Suppl, 3(3), S177–8. https://www.ncbi.nlm.nih.gov/pubmed/2908815
  542. Refson, J. S., Schachter, M., Patel, M. K., Hughes, A. D., Munro, E., Chan, P., Wolfe, J. H., & Sever, P. S. (1998). Vein graft stenosis and the heparin responsiveness of human vascular smooth muscle cells [Journal Article]. Circulation, 97(25), 2506–2510. https://www.ncbi.nlm.nih.gov/pubmed/9657470
  543. Robinson, O., Carter, A. R., Ala-Korpela, M., Casas, J. P., Chaturvedi, N., Engmann, J., Howe, L. D., Hughes, A. D., Jarvelin, M. R., Kahonen, M., Karhunen, V., Kuh, D., Shah, T., Ben-Shlomo, Y., Sofat, R., Lau, C. E., Lehtimaki, T., Menon, U., Raitakari, O., … Vineis, P. (2021). Metabolic profiles of socio-economic position: a multi-cohort analysis [Journal Article]. Int J Epidemiol, 50(3), 768–782. https://doi.org/10.1093/ije/dyaa188
  544. Salman, M. S., Hughes, A., Maddock, J., James, S., & Thomas, O. (2024). Abstracts from the 26th Meeting of the European Council for Cardiovascular Research (ECCR) [Journal Article]. Clinical Science, 137(S1), A1–A42. https://doi.org/10.1042/cs2023eccr001
  545. Santos Ferreira, D. L., Fraser, A., Howe, L. D., Jones, S., Tapp, R., Lawlor, D. A., Ness, A., Smith, G. D., Chaturvedi, N., & Hughes, A. D. (2013). Associations of central and peripheral pulse pressure with heart structure, systolic and diastolic function in adolescence: Findings from a general population cohort [Journal Article]. Artery Res, 7(3-4), 130. https://doi.org/10.1016/j.artres.2013.10.101
  546. Sawhney, N., Patel, M. K., Schachter, M., & Hughes, A. D. (1997). Inhibition of proliferation by heparin and expression of p53 in cultured human vascular smooth muscle cells [Journal Article]. J Hum Hypertens, 11(9), 611–614. https://doi.org/10.1038/sj.jhh.1000495
  547. Schachter, M., Betteridge, L. J., Hughes, A. D., & Patel, M. K. (1995). Angiotensin II receptors are exclusively of the AT1 subtype in cultured human vascular smooth muscle cells [Journal Article]. Biochem Soc Trans, 23(3), 458S. http://www.ncbi.nlm.nih.gov/pubmed/8566350
  548. Schachter, M., Betteridge, L. J., Hughes, A. D., & Patel, M. K. (1995). Angiotensin-II Receptors Are Exclusively of the AT(1) Subtype in Cultured Human Vascular Smooth-Muscle Cells [Journal Article]. Biochem Soc Trans, 23(3), S458–S458. https://doi.org/10.1042/bst023458s
  549. Schachter, M., & Hughes, A. D. (1994). Effect of Platelet-Derived Growth-Factor Isoforms on Intracellular Ca2+ in Human Vascular Smooth-Muscle Cells [Journal Article]. British Journal of Pharmacology, 111, P306–P306. ://WOS:A1994MR86300210 https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1994.tb14752.x</span></li>
  550. Schachter, M., Hughes, A. D., Martin, G. N., Hair, W. M., Nielsen, H., Thom, S., & Sever, P. S. (1987). Effect of neuropeptide Y on isolated human blood vessels [Journal Article]. J Hypertens, 5(Supplement 5), S129–S131.
  551. Schmidt, A. F., Hunt, N. B., Gordillo-Maranon, M., Charoen, P., Drenos, F., Kivimaki, M., Lawlor, D. A., Giambartolomei, C., Papacosta, O., Chaturvedi, N., Bis, J. C., O’Donnell, C. J., Wannamethee, G., Wong, A., Price, J. F., Hughes, A. D., Gaunt, T. R., Franceschini, N., Mook-Kanamori, D. O., … Finan, C. (2021). Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease [Journal Article]. Nat Commun, 12(1), 5640. https://doi.org/10.1038/s41467-021-25703-3
  552. Schmidt, A. F., Joshi, R., Gordillo-Maranon, M., Drenos, F., Charoen, P., Giambartolomei, C., Bis, J. C., Gaunt, T. R., Hughes, A. D., Lawlor, D. A., Wong, A., Price, J. F., Chaturvedi, N., Wannamethee, G., Franceschini, N., Kivimaki, M., Hingorani, A. D., & Finan, C. (2023). Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes [Journal Article]. Commun Med (Lond), 3(1), 9. https://doi.org/10.1038/s43856-022-00234-0
  553. Schultz, M. G., Davies, J. E., Hardikar, A., Pitt, S., Moraldo, M., Dhutia, N., Hughes, A. D., & Sharman, J. E. (2014). Aortic reservoir pressure corresponds to cyclic changes in aortic volume: physiological validation in humans [Journal Article]. Arterioscler Thromb Vasc Biol, 34(7), 1597–1603. https://doi.org/10.1161/ATVBAHA.114.303573
  554. Schultz, M. G., Davies, J. E., Roberts-Thomson, P., Black, J. A., Hughes, A. D., & Sharman, J. E. (2013). Exercise central (aortic) blood pressure is predominantly driven by forward traveling waves, not wave reflection [Journal Article]. Hypertension, 62(1), 175–182. https://doi.org/10.1161/HYPERTENSIONAHA.111.00584
  555. Schultz, M. G., Davies, J. E., Roberts-Thomson, P., Black, J. A., Hughes, A. D., & Sharman, J. E. (2013). Response to a new exercise central hemodynamics paradigm: Time for reflection or expansion? [Journal Article]. Hypertension, 62(5). https://doi.org/10.1161/HYPERTENSIONAHA.113.02142
  556. Schultz, M. G., Hughes, A. D., Davies, J. E., & Sharman, J. E. (2015). Associations and clinical relevance of aortic-brachial artery stiffness mismatch, aortic reservoir function and central pressure augmentation [Journal Article]. Am J Physiol Heart Circ Physiol, ajpheart 00317 2015. https://doi.org/10.1152/ajpheart.00317.2015
  557. Schultz, M. G., Park, C., Fraser, A., Howe, L. D., Jones, S., Rapala, A., Davey Smith, G., Sharman, J. E., Lawlor, D. A., Chaturvedi, N., Deanfield, J., & Hughes, A. D. (2019). Submaximal exercise blood pressure and cardiovascular structure in adolescence [Journal Article]. Int J Cardiol, 275, 152–157. https://doi.org/10.1016/j.ijcard.2018.10.060
  558. Segers, P., O’Rourke, M. F., Parker, K., Westerhof, N., Hughes, A., Aguado-Sierra, J., Aizawa, K., Alastruey, J., Allen, J., Avolio, A., Chen, C.-H., Cheng, H.-M., Faita, F., Fraser, A., Gavish, B., Greenwald, S., Hametner, B., Holewijn, S., Di Lascio, N., … Westerhof, B. E. (2017). Towards a consensus on the understanding and analysis of the pulse waveform: Results from the 2016 Workshop on Arterial Hemodynamics: Past, present and future [Journal Article]. Artery Res, 18, 75–80. https://doi.org/10.1016/j.artres.2017.03.004
  559. Sen, S., Asrress, K., Petraco, R., Nijjer, S., Broyd, C., Foin, N., Foale, R., Malik, I., Mikhail, G., Sethi, A., Khan, M., Khawaja, M., Hughes, A., Francis, D., Baker, C., Mayet, J., Di Mario, C., Escaned, J., Redwood, S., & Davies, J. (2012). Does Adenosine Administration Improve Diagnostic Classification Of The Instantaneous Wave-Free Ratio (iFR)? [Journal Article]. Journal of the American College of Cardiology, 60(17), B69–B69. https://doi.org/10.1016/j.jacc.2012.08.262
  560. Sen, S., Asrress, K. N., Nijjer, S., Petraco, R., Malik, I. S., Foale, R. A., Mikhail, G. W., Foin, N., Broyd, C., Hadjiloizou, N., Sethi, A., Al-Bustami, M., Hackett, D., Khan, M. A., Khawaja, M. Z., Baker, C. S., Bellamy, M., Parker, K. H., Hughes, A. D., … Davies, J. E. (2013). Diagnostic classification of the instantaneous wave-free ratio is equivalent to fractional flow reserve and is not improved with adenosine administration. Results of CLARIFY (Classification Accuracy of Pressure-Only Ratios Against Indices Using Flow Study) [Journal Article]. J Am Coll Cardiol, 61(13), 1409–1420. https://doi.org/10.1016/j.jacc.2013.01.034
  561. Sen, S., Davies, J., Nijjer, S., Cunha, R. P. da, Foale, R., Malik, I., Mikhail, G., Asrress, K., Hughes, A., Escaned, J., Francis, D., Redwood, S., & Mayet, J. (2013). Fractional Flow Reserve and the Instant Wave–Free Ratio Have Equivalent Agreement with Flow–Based Indices across the Entire Spectrum of Stenosis Severity Results of the Clarify Study Results of Clarify (the Classification Accuracy of Pressure–Only Ratios against Indices Using Flow Study) [Journal Article]. Journal of the American College of Cardiology, 61(10), E1769. https://doi.org/10.1016/s0735-1097(13)61769-6
  562. Sen, S., Davies, J. E., Malik, I. S., Foale, R. A., Mikhail, G. W., Hadjiloizou, N., Hughes, A., Mayet, J., & Francis, D. P. (2012). Why does primary angioplasty not work in registries? Quantifying the susceptibility of real-world comparative effectiveness data to allocation bias [Journal Article]. Circ Cardiovasc Qual Outcomes, 5(6), 759–766. https://doi.org/10.1161/CIRCOUTCOMES.112.966853
  563. Sen, S., Davies, J. E., Malik, S., Hadjiloizou, N., Foale, R. A., Baruah, R., Ghada, W., Hughes, A. D., Mayet, J., & Francis, D. Why Does Primary Angioplasty Not Work in Observational Studies When It Works Consistently in Randomised Controlled Trials? An Analysis of 51242 Patients with St Elevation Myocardial Infarction [Conference Proceedings]. Heart, 96, A73–A74. https://doi.org/10.1136/hrt.2010.196089.22
  564. Sen, S., Escaned, J., Malik, I., Mikhail, G., Foale, R., Mila, R., Tarkin, J., Petraco, R., Broyd, C., Jabbour, R., Sethi, A., Baker, C., Bellamy, M., Al-Bustami, M., Hackett, D., Khan, M., Lefroy, D., Parker, K., Hughes, A., … Davies, J. (2012). Development and Validation of a Novel Pressure-Only Intra-Coronary Index of Coronary Stenosis Severity [Journal Article]. Heart, 98, A13. https://doi.org/10.1136/heartjnl-2012-301877b.19
  565. Sen, S., Escaned, J., Malik, I. S., Mikhail, G. W., Foale, R. A., Mila, R., Tarkin, J., Petraco, R., Broyd, C., Jabbour, R., Sethi, A., Baker, C. S., Bellamy, M., Al-Bustami, M., Hackett, D., Khan, M., Lefroy, D., Parker, K. H., Hughes, A. D., … Davies, J. E. (2012). Development and validation of a new adenosine-independent index of stenosis severity from coronary wave-intensity analysis: results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study [Journal Article]. J Am Coll Cardiol, 59(15), 1392–1402. https://doi.org/10.1016/j.jacc.2011.11.003
  566. Sen, S., Francis, D., Petraco, R., Broyd, C., Nijjer, S., Foin, N., Malik, I., Mikhail, G., Foale, R., Hughes, A., Mayet, J., & Davies, J. (2012). Should We Discourage the Use of Multi-Vessel Angioplasty during Stemi or the Use of Registry Data in Comparative Efficacy Research? An Analysis of 35,008 Patients [Journal Article]. Journal of the American College of Cardiology, 59(13), E515–E515. https://doi.org/10.1016/S0735-1097(12)60516-6
  567. Sen, S., Francis, D., Petraco, R., Nijjer, S., Foin, N., Foale, R., Hadjiloizou, N., Hughes, A., Mikhail, G., Malik, I., & Davies, J. (2012). TCT-526 Is There Sufficient Evidence To Discourage The Use Of Multi-Vessel Angioplasty During STEMI? An Analysis of 35,008 Patients [Journal Article]. Journal of the American College of Cardiology, 60(17), B152. https://doi.org/10.1016/j.jacc.2012.08.558
  568. Sen, S., Nijjer, S., Petraco, R., Asrress, K., Broyd, C., Foin, N., Foale, R., Malik, I., Mikhail, G., Baker, C., Khan, M., Khawaja, M., Sethi, A., Francis, D., Hughes, A., Mayet, J., Di Mario, C., Escaned, J., Redwood, S., & Davies, J. (2012). The Instantaneous Wave-Free Ratio (iFR) and Fractional Flow Reserve (FFR) Have Equivalent Diagnostic Categorisation When Compared To Flow Based Indices [Journal Article]. Journal of the American College of Cardiology, 60(17), B68–B69. ://WOS:000310210101040</span></li>
  569. Sen, S., Nijjer, S., Petraco, R., Broyd, C., Foin, N., Malik, I., Mikhail, G., Foale, R., Francis, D., Hughes, A., Mayet, J., & Davies, J. (2012). Stability of the Diastolic Wave-Free Period after Pharamocological Provocation, and during Haemodynamic Perturbations: Implications for the Clinical Applicability of the Instantaneous Wave-Free Ratio (Ifr) [Journal Article]. Journal of the American College of Cardiology, 59(13), E1437–E1437. https://doi.org/10.1016/S0735-1097(12)61438-7
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  571. Sen, S., Nijjer, S., Petraco, R., Malik, I., Foale, R., Mikhail, G., Sethi, A., Escaned, J., Hughes, A., Francis, D., Mayet, J., & Davies, J. (2013). The Effect of Adenosine on Coronary Microvascular Resistance Is More Consistent During the Diastolic Wave-free Period: Should We Continue to Use the Complete Cardiac Cycle for Stenosis Assessment? [Journal Article]. Am J Cardiol, 111(7), 100B–101B. http://ac.els-cdn.com/S0002914913003111/1-s2.0-S0002914913003111-main.pdf?_tid=b5d2af8c-b01b-11e6-98ac-00000aacb362&acdnat=1479754554_768bfa0714a2aa440ef234920f65410e
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  575. Seraphim, A., Knott, K. D., Menacho, K., Augusto, J. B., Davies, R., Pierce, I., Joy, G., Bhuva, A. N., Xue, H., Treibel, T. A., Cooper, J. A., Petersen, S. E., Fontana, M., Hughes, A. D., Moon, J. C., Manisty, C., & Kellman, P. (2021). Prognostic Value of Pulmonary Transit Time and Pulmonary Blood Volume Estimation Using Myocardial Perfusion CMR [Journal Article]. JACC Cardiovasc Imaging, 14(11), 2107–2119. https://doi.org/10.1016/j.jcmg.2021.03.029
  576. Sever, P. S., & Hughes, A. (2001). Angiotensin receptor antagonists and vaso-vagal attacks due to sensitisation of the Bezold-Jarisch reflex? [Journal Article]. J Hum Hypertens, 15(6), 437–438. https://doi.org/10.1038/sj.jhh.1001190
  577. Sever, P. S., Poulter, N. R., Chang, C. L., Hingorani, A., Thom, S. A., Hughes, A. D., Welsh, P., & Sattar, N. (2012). Evaluation of C-reactive protein prior to and on-treatment as a predictor of benefit from atorvastatin: observations from the Anglo-Scandinavian Cardiac Outcomes Trial [Journal Article]. Eur Heart J, 33(4), 486–494. https://doi.org/10.1093/eurheartj/ehr262
  578. Sever, P. S., Poulter, N. R., Chang, C. L., Thom, S. A., Hughes, A. D., Welsh, P., & Sattar, N. (2013). Evaluation of C-reactive protein before and on-treatment as a predictor of benefit of atorvastatin: a cohort analysis from the Anglo-Scandinavian Cardiac Outcomes Trial lipid-lowering arm [Journal Article]. J Am Coll Cardiol, 62(8), 717–729. https://doi.org/10.1016/j.jacc.2013.02.098
  579. Shan, M., Yang, X., Ezzati, M., Chaturvedi, N., Coady, E., Hughes, A., Shi, Y., Yang, M., Zhang, Y., & Baumgartner, J. (2014). A feasibility study of the association of exposure to biomass smoke with vascular function, inflammation, and cellular aging [Journal Article]. Environ Res, 135, 165–172. https://doi.org/10.1016/j.envres.2014.09.006
  580. Sharma, V., Al Saikhan, L., Park, C., Hughes, A., Gu, H., Saeed, S., Boguslavskyi, A., Carr-White, G., Chambers, J., Chowienczyk, P., Jain, M., Jessop, H., Turner, C., Bassindale-Maguire, G., Baig, W., Kidambi, A., Abdel-Rahman, S. T., Schlosshan, D., Sengupta, A., … Masters, A. T. (2020). Report from the Annual Conference of the British Society of Echocardiography, October 2018, ACC Liverpool, Liverpool [Journal Article]. Echo Res Pract, 7(4), M1. https://doi.org/10.1530/ERP-20-0037
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  583. Sharp, A., Tapp, R., Francis, D. P., Mc, G. T. S. A., Hughes, A. D., Stanton, A. V., Zambanini, A., Chaturvedi, N., Byrd, S., Poulter, N. R., Sever, P. S., & Mayet, J. (2008). Ethnicity and left ventricular diastolic function in hypertension an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy [Journal Article]. J Am Coll Cardiol, 52(12), 1015–1021. https://doi.org/10.1016/j.jacc.2008.04.065
  584. Sharp, A., Thom, S., Hughes, A., Francis, D., Stanton, A., O’Brien, E., Fitzgerald, D., Shields, D., Poulter, N., Sever, P., & Mayet, J. (2005). Black hypertensives have significantly lower B-Natriuretic peptide levels than South Asians or Whites [Journal Article]. Journal of the American College of Cardiology, 45(3), 381A.
  585. Sharp, A. J., Sohaib, S. M. A., Shun-Shin, M. J., Pabari, P., Willson, K., Rajkumar, C., Hughes, A. D., Kanagaratnam, P., Mayet, J., Whinnett, Z. I., Kyriacou, A. A., & Francis, D. P. (2019). Improving haemodynamic optimization of cardiac resynchronization therapy for heart failure [Journal Article]. Physiol Meas, 40(4), 04NT01. https://doi.org/10.1088/1361-6579/ab152c
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  587. Sharp, A. S., Zambanini, A., Hughes, A. D., Byrd, S., Shields, D., Fitzgerald, D., Lyons, S., O’Brien, E., Stanton, A., Poulter, N., Sever, P. S., Thom, S. A. G., & Mayet, J. (2003). Atorvastatin does not reduce LV mass or affect diastolic function after one year of treatment [Journal Article]. Heart, 89, 41–42. ://WOS:000186265800027 http://heart.bmj.com/content/heartjnl/89/1/41.full.pdf</span></li>
  588. Shibata, D., Tillin, T., Beauchamp, N., Heasman, J., Hughes, A. D., Park, C., Gedroyc, W., & Chaturvedi, N. (2013). African Caribbeans have greater subclinical cerebrovascular disease than Europeans: this is associated with both their elevated resting and ambulatory blood pressure and their hyperglycaemia [Journal Article]. J Hypertens, 31(12), 2391–2399. https://doi.org/10.1097/HJH.0b013e328364f5bc
  589. Shimizu, L. S., Hughes, A. D., Smith, M. D., Samuel, S. A., & Ciurtin-Smith, D. (2005). Assembled columnar structures from bis-urea macrocycles [Journal Article]. Supramolecular Chemistry, 17(1-2), 27–30. https://doi.org/10.1080/10610270412331328989
  590. Shiwani, H., Davies, R. H., Topriceanu, C. C., Ditaranto, R., Owens, A., Raman, B., Augusto, J., Hughes, R. K., Torlasco, C., Dowsing, B., Artico, J., Joy, G., Miranda, I., Witschey, W., Rodriguez-Palomares, J. F., Badia-Molins, C., Crotti, L., Cortina-Borja, M., Chuang, M. L., … Collaborative, P.-H. (2025). Demographic-Based Personalized Left Ventricular Hypertrophy Thresholds for Hypertrophic Cardiomyopathy Diagnosis [Journal Article]. J Am Coll Cardiol, 85(7), 685–695. https://doi.org/10.1016/j.jacc.2024.10.082
  591. Simonsen, U., Krojgaard, C., Stankevicius, E., Schjorring, O., Litvin, K., & Hughes, A. (2007). A novel opener of small and intermediate calcium-activated K channels releases NO and causes EDHF type vasodilatation in rat mesenteric arteries [Journal Article]. Hypertension, 50(4), 802.
  592. Sinclair, A. M., Hughes, A. D., & Sever, P. S. (1993). Effect of nifedipine and glyceryl trinitrate on retinal blood flow in normal subjects [Journal Article]. J Hum Hypertens, 7(4), 399–401. https://www.ncbi.nlm.nih.gov/pubmed/8410935
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  594. Singer, D. R. J., Cappuccio, F. P., Carter, N. D., & Hughes, A. D. (2000). Highlight on: Proceedings of the 11th Annual Symposium of the London Hypertension Society - New themes in hypertension [Journal Article]. Nutrition Metabolism and Cardiovascular Diseases, 10(4), 223–228. ://WOS:000089988500008</span></li>
  595. Singer, D. R. J., Cappuccio, F. P., Carter, N. D., & Hughes, A. D. (2000). Proceedings of the 10th Annual Symposium of the London Hypertension Society [Journal Article]. Journal of Human Hypertension, 14(6). https://doi.org/10.1038/sj.jhh.1001019
  596. Singer, D. R. J., Cappuccio, F. P., & Hughes, A. D. (1997). New themes in hypertension: Introduction [Journal Article]. Journal of Human Hypertension, 11(9), 551–552. https://doi.org/10.1038/sj.jhh.1000530
  597. Sluyter, J. D., Camargo, J., C. A., Stewart, A. W., Waayer, D., Lawes, C. M. M., Toop, L., Khaw, K. T., Thom, S. A. M., Hametner, B., Wassertheurer, S., Parker, K. H., Hughes, A. D., & Scragg, R. (2017). Effect of Monthly, High-Dose, Long-Term Vitamin D Supplementation on Central Blood Pressure Parameters: A Randomized Controlled Trial Substudy [Journal Article]. J Am Heart Assoc, 6(10). https://doi.org/10.1161/jaha.117.006802
  598. Sluyter, J. D., Hughes, A. D., Camargo, J., C. A., Lowe, A., & Scragg, R. K. R. (2017). Relations of Demographic and Clinical Factors With Cardiovascular Autonomic Function in a Population-Based Study: An Assessment By Quantile Regression [Journal Article]. Am J Hypertens, 31(1), 53–62. https://doi.org/10.1093/ajh/hpx134
  599. Sluyter, J. D., Hughes, A. D., Camargo, J., C. A., Thom, S. A. M., Parker, K. H., Hametner, B., Wassertheurer, S., & Scragg, R. (2019). Identification of Distinct Arterial Waveform Clusters and a Longitudinal Evaluation of Their Clinical Usefulness [Journal Article]. Hypertension, 74(4), 921–928. https://doi.org/10.1161/HYPERTENSIONAHA.119.12625
  600. Sluyter, J. D., Hughes, A. D., Lowe, A., Camargo, J., C. A., & Scragg, R. K. (2016). Statin utilisation in a real-world setting: a retrospective analysis in relation to arterial and cardiovascular autonomic function [Journal Article]. Pharmacol Res Perspect, 4(6), e00276. https://doi.org/10.1002/prp2.276
  601. Sluyter, J. D., Hughes, A. D., Lowe, A., Parker, K. H., Camargo, J., C. A., Hametner, B., Wassertheurer, S., & Scragg, R. K. (2016). Different associations between beta-blockers and other antihypertensive medication combinations with brachial blood pressure and aortic waveform parameters [Journal Article]. Int J Cardiol, 219, 257–263. https://doi.org/10.1016/j.ijcard.2016.06.051
  602. Smith, L. A., Melbourne, A., Owen, D., Cardoso, M. J., Sudre, C. H., Tillin, T., Sokolska, M., Atkinson, D., Chaturvedi, N., Ourselin, S., Hughes, A. D., Barkhof, F., & Jager, H. R. (2019). Cortical cerebral blood flow in ageing: effects of haematocrit, sex, ethnicity and diabetes [Journal Article]. Eur Radiol, 29(10), 5549–5558. https://doi.org/10.1007/s00330-019-06096-w
  603. Sofat, R., Casas, J. P., Kumari, M., Talmud, P. J., Ireland, H., Kivimaki, M., Marmot, M., Hughes, A. D., Thom, S., Ebrahim, S., Whittaker, J. C., Smeeth, L., Lawlor, D. A., Humphries, S. E., & Hingorani, A. D. (2010). Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals [Journal Article]. Atherosclerosis, 213(1), 184–190. https://doi.org/10.1016/j.atherosclerosis.2010.07.021
  604. Sofat, R., Cooper, J. A., Kumari, M., Casas, J. P., Mitchell, J. P., Acharya, J., Thom, S., Hughes, A. D., Humphries, S. E., & Hingorani, A. D. (2016). Circulating Apolipoprotein E Concentration and Cardiovascular Disease Risk: Meta-analysis of Results from Three Studies [Journal Article]. PLoS Med, 13(10), e1002146. https://doi.org/10.1371/journal.pmed.1002146
  605. Sohaib, S. M., Kyriacou, A., Jones, S., Manisty, C. H., Mayet, J., Kanagaratnam, P., Peters, N. S., Hughes, A. D., Whinnett, Z. I., & Francis, D. P. (2015). Evidence that conflict regarding size of haemodynamic response to interventricular delay optimization of cardiac resynchronization therapy may arise from differences in how atrioventricular delay is kept constant [Journal Article]. Europace, 17(12), 1823–1833. https://doi.org/10.1093/europace/euu374
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  607. Stankevicius, E., Dalsgaard, T., Kroigaard, C., Beck, L., Boedtkjer, E., Misfeldt, M. W., Nielsen, G., Schjorring, O., Hughes, A., & Simonsen, U. (2011). Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat [Journal Article]. J Pharmacol Exp Ther, 339(3), 842–850. https://doi.org/10.1124/jpet.111.179242
  608. Stankevicius, E., Lopez-Valverde, V., Rivera, L., Hughes, A. D., Mulvany, M. J., & Simonsen, U. (2006). Combination of Ca2+ -activated K+ channel blockers inhibits acetylcholine-evoked nitric oxide release in rat superior mesenteric artery [Journal Article]. Br J Pharmacol, 149(5), 560–572. https://doi.org/10.1038/sj.bjp.0706886
  609. Stanton, A., Fitzgerald, D., Hughes, A., Mayet, J., O’Brien, E., Poulter, N. R., Sever, P. S., Shields, D., Thom, S., & Anglo-Scandinavian Cardiac Outcomes, T. (2001). An intensive phenotyping study to enable the future examination of genetic influences on hypertension-associated cardiovascular disease [Journal Article]. J Hum Hypertens, 15 Suppl 1, S13–8. http://www.ncbi.nlm.nih.gov/pubmed/11685902
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  612. Stanton, A. V., Wasan, B., Cerutti, A., Ford, S., Marsh, R., Sever, P. S., Thom, S. A., & Hughes, A. D. (1995). Vascular network changes in the retina with age and hypertension [Journal Article]. J Hypertens, 13(12 Pt 2), 1724–1728. http://www.ncbi.nlm.nih.gov/pubmed/8903640
  613. Starke, R. D., Paschalaki, K. E., Ferraro, F., Dryden, N. H., McKinnon, T. A. J., Sutton, R. E., Payne, E. M., Haskard, D. O., Hughes, A. D., Cutler, D. F., Laffan, M. A., & Randi, A. M. (2011). Blood-Derived Endothelial Progenitor Cells from Von Willebrand’s Disease Patients Demonstrate That Von Willebrand Factor Regulates Angiogenesis [Journal Article]. Heart, 97(20), 14–14. https://doi.org/10.1136/heartjnl-2011-300920b.39
  614. Starke, R. D., Paschalaki, K. E., Ferraro, F., Dryden, N. H., McKinnon, T. A. J., Sutton, R. E., Payne, E. M., Haskard, D. O., Hughes, A. D., Cutler, D. F., Laffan, M. A., & Randi, A. M. (2012). Endothelial Von Willebrand factor regulates angiogenesis [Journal Article]. Vascular Pharmacology, 56(5-6), 318–319. https://doi.org/10.1016/j.vph.2011.08.038
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  616. Starmans-Kool, M. J., Stanton, A. V., Zhao, S., Xu, X. Y., Thom, S. A., & Hughes, A. D. (2002). Measurement of hemodynamics in human carotid artery using ultrasound and computational fluid dynamics [Journal Article]. J Appl Physiol (1985), 92(3), 957–961. https://doi.org/10.1152/japplphysiol.00171.2001
  617. Stettler, C., Witt, N., Tapp, R. J., Thom, S., Allemann, S., Tillin, T., Stanton, A., O’Brien, E., Poulter, N., Gallimore, J. R., Hughes, A. D., & Chaturvedi, N. (2009). Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy [Journal Article]. Diabetes Care, 32(6), 1098–1100. https://doi.org/10.2337/dc08-2137
  618. Stolk, R. P., van Schooneveld, M. J., Cruickshank, J. K., Hughes, A. D., Stanton, A., Lu, J., Patel, A., Thom, S. A., Grobbee, D. E., & Vingerling, J. R. (2008). Retinal vascular lesions in patients of Caucasian and Asian origin with type 2 diabetes: baseline results from the ADVANCE Retinal Measurements (AdRem) study [Journal Article]. Diabetes Care, 31(4), 708–713. https://doi.org/10.2337/dc07-1657
  619. Stolk, R. P., Vingerling, J. R., Cruickshank, J. K., Hughes, A. D., Stanton, A., Juming, L., Patel, A., Thom, S. A., & Grobbee, D. E. (2007). Rationale and design of the AdRem study: evaluating the effects of blood pressure lowering and intensive glucose control on vascular retinal disorders in patients with type 2 diabetes mellitus [Journal Article]. Contemp Clin Trials, 28(1), 6–17. https://doi.org/10.1016/j.cct.2006.08.011
  620. Strain, W. D., Chaturvedi, N., Hughes, A., Nihoyannopoulos, P., Bulpitt, C. J., Rajkumar, C., & Shore, A. C. (2010). Associations between cardiac target organ damage and microvascular dysfunction: the role of blood pressure [Journal Article]. J Hypertens, 28(5), 952–958. https://doi.org/10.1097/HJH.0b013e328336ad6c
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  624. Su, J., Hughes, A. D., Simonsen, U., & Howard, L. S. (2018). Nitric Oxide Attenuates Arterial Pulse Wave Reflection in a Vasodilator Responding Pulmonary Arterial Hypertension Patient [Journal Article]. Circ Cardiovasc Interv, 11(3), e006242. https://doi.org/10.1161/circinterventions.117.006242
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  626. Su, J., Logan, C. C., Hughes, A. D., Parker, K. H., Dhutia, N. M., Danielsen, C. C., & Simonsen, U. (2018). Impact of chronic hypoxia on proximal pulmonary artery wave propagation and mechanical properties in rats [Journal Article]. Am J Physiol Heart Circ Physiol, 314(6), H1264–h1278. https://doi.org/10.1152/ajpheart.00695.2017
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  628. Su, J., Manisty, C., Simonsen, U., Howard, L. S., Parker, K. H., & Hughes, A. D. (2017). Pulmonary artery wave propagation and reservoir function in conscious man: impact of pulmonary vascular disease, respiration and dynamic stress tests [Journal Article]. J Physiol, 595(20), 6463–6476. https://doi.org/10.1113/JP274385
  629. Su, J., Simonsen, U., Mellemkjaer, S., Howard, L. S., Manisty, C., & Hughes, A. D. (2021). Limited value of pulse wave analysis in assessing arterial wave reflection and stiffness in the pulmonary artery [Journal Article]. Physiol Rep, 9(18), e15024. https://doi.org/10.14814/phy2.15024
  630. Sudre, C. H., Gomez Anson, B., Davagnanam, I., Schmitt, A., Mendelson, A. F., Prados, F., Smith, L., Atkinson, D., Hughes, A. D., Chaturvedi, N., Cardoso, M. J., Barkhof, F., Jaeger, H. R., & Ourselin, S. (2018). Bullseye’s representation of cerebral white matter hyperintensities [Journal Article]. J Neuroradiol, 45(2), 114–122. https://doi.org/10.1016/j.neurad.2017.10.001
  631. Sudre, C. H., Moriconi, S., Rehwald, R., Smith, L., Tillin, T., Barnes, J., Atkinson, D., Ourselin, S., Chaturvedi, N., Hughes, A. D., Jager, H. R., & Cardoso, M. J. (2022). Accelerated vascular aging: Ethnic differences in basilar artery length and diameter, and its association with cardiovascular risk factors and cerebral small vessel disease [Journal Article]. Front Cardiovasc Med, 9, 939680. https://doi.org/10.3389/fcvm.2022.939680
  632. Sudre, C. H., Smith, L., Atkinson, D., Chaturvedi, N., Ourselin, S., Barkhof, F., Hughes, A. D., Jager, H. R., & Cardoso, M. J. (2018). Cardiovascular Risk Factors and White Matter Hyperintensities: Difference in Susceptibility in South Asians Compared With Europeans [Journal Article]. J Am Heart Assoc, 7(21), e010533. https://doi.org/10.1161/JAHA.118.010533
  633. Sudre, C. H., Van Wijnen, K., Dubost, F., Adams, H., Atkinson, D., Barkhof, F., Birhanu, M. A., Bron, E. E., Camarasa, R., Chaturvedi, N., Chen, Y., Chen, Z., Chen, S., Dou, Q., Evans, T., Ezhov, I., Gao, H., Girones Sanguesa, M., Gispert, J. D., … study, A. (2023). Where is VALDO? VAscular Lesions Detection and segmentatiOn challenge at MICCAI 2021 [Journal Article]. Med Image Anal, 91, 103029. https://doi.org/10.1016/j.media.2023.103029
  634. Sun, N., Leung, J. H., Wood, N. B., Hughes, A. D., Thom, S. A., Cheshire, N. J., & Xu, X. Y. (2009). Computational analysis of oxygen transport in a patient-specific model of abdominal aortic aneurysm with intraluminal thrombus [Journal Article]. Br J Radiol, 82 Spec No 1, S18–23. https://doi.org/10.1259/bjr/89466318
  635. Sun, N., Torii, R., Wood, N. B., Hughes, A. D., Thom, S. A., & Xu, X. Y. (2009). Computational modeling of LDL and albumin transport in an in vivo CT image-based human right coronary artery [Journal Article]. J Biomech Eng, 131(2), 021003. https://doi.org/10.1115/1.3005161
  636. Sun, N., Torii, R., Wood, N. B., Wright, A., Hughes, A. D., Thom, S. A. M., & Xu, X. Y. (2007). Numerical simulation of blood-wall albumin transport in a realistic human right coronary artery [Journal Article]. Proceeding of the Asme Summer Bioengineering Conference - 2007, 107–108. ://WOS:000252105700054</span></li>
  637. Sun, N., Wood, N. B., Hughes, A. D., Thom, S. A., & Xu, X. Y. (2006). Effects of shear-dependent transport properties on mass transfer in stenosed arteries [Journal Article]. Journal of Biomechanics, 39, S375. https://doi.org/https://doi.org/10.1016/S0021-9290(06)84508-2
  638. Sun, N., Wood, N. B., Hughes, A. D., Thom, S. A., & Xu, X. Y. (2006). Fluid-wall modelling of mass transfer in an axisymmetric stenosis: effects of shear-dependent transport properties [Journal Article]. Ann Biomed Eng, 34(7), 1119–1128. https://doi.org/10.1007/s10439-006-9144-2
  639. Sun, N., Wood, N. B., Hughes, A. D., Thom, S. A., & Xu, X. Y. (2007). Influence of pulsatile flow on LDL transport in the arterial wall [Journal Article]. Ann Biomed Eng, 35(10), 1782–1790. https://doi.org/10.1007/s10439-007-9347-1
  640. Sun, N., Wood, N. B., Hughes, A. D., Thom, S. A., & Yun Xu, X. (2007). Effects of transmural pressure and wall shear stress on LDL accumulation in the arterial wall: a numerical study using a multilayered model [Journal Article]. Am J Physiol Heart Circ Physiol, 292(6), H3148–57. https://doi.org/10.1152/ajpheart.01281.2006
  641. Sunman, W., Hughes, A. D., & Sever, P. S. (1992). Anaphylactoid response to intravenous acetylcysteine [Journal Article]. Lancet, 339(8803), 1231–1232. https://doi.org/10.1016/0140-6736(92)91171-4
  642. Sunman, W., Hughes, A. D., & Sever, P. S. (1993). Free-radical scavengers, thiol-containing reagents and endothelium-dependent relaxation in isolated rat and human resistance arteries [Journal Article]. Clin Sci (Lond), 84(3), 287–295. https://doi.org/10.1042/cs0840287
  643. Sunman, W., Martin, G., Hair, W. M., Sever, P. S., & Hughes, A. D. (1993). Effect of calcium antagonists on endothelin-induced contraction of isolated human resistance arteries: differences related to site of origin [Journal Article]. J Hum Hypertens, 7(2), 189–191. https://www.ncbi.nlm.nih.gov/pubmed/8389874
  644. Suri, S., Bulte, D., Chiesa, S. T., Ebmeier, K. P., Jezzard, P., Rieger, S. W., Pitt, J. E., Griffanti, L., Okell, T. W., Craig, M., Chappell, M. A., Blockley, N. P., Kivimaki, M., Singh-Manoux, A., Khir, A. W., Hughes, A. D., Deanfield, J. E., Jensen, D. E. A., Green, S. F., … Mackay, C. E. (2021). Study Protocol: The Heart and Brain Study [Journal Article]. Front Physiol, 12, 643725. https://doi.org/10.3389/fphys.2021.643725
  645. Tan, F. P., Soloperto, G., Bashford, S., Wood, N. B., Thom, S., Hughes, A., & Xu, X. Y. (2008). Analysis of flow disturbance in a stenosed carotid artery bifurcation using two-equation transitional and turbulence models [Journal Article]. J Biomech Eng, 130(6), 061008. https://doi.org/10.1115/1.2978992
  646. Tan, F. P. P., Soloperto, G., Wood, N. B., Thom, S., Hughes, A., & Xu, X. Y. Advanced computational models for disturbed and turbulent flow in stenosed human carotid artery bifurcation [Conference Proceedings]. IFMBE Proceedings, 21 IFMBE, 390–394. https://doi.org/10.1007/978-3-540-69139-6-99
  647. Tandirerung, F. J., Jamieson, A., Hendrick, E., Hughes, A. D., & Jones, S. (2024). Near-infrared spectroscopy (NIRS) in vivo assessment of skeletal muscle oxidative capacity: a comparison of results from short versus long exercise protocols and reproducibility in non-athletic adults [Journal Article]. Front Physiol, 15, 1429673. https://doi.org/10.3389/fphys.2024.1429673
  648. Tang, R., Abeysekera, K. W. M., Howe, L. D., Hughes, A. D., & Fraser, A. (2023). Non-alcoholic fatty liver and fibrosis is associated with cardiovascular structure and function in young adults [Journal Article]. Hepatol Commun, 7(4). https://doi.org/10.1097/HC9.0000000000000087
  649. Tapp, R. J., Hughes, A. D., Kahonen, M., Wong, T. Y., Witt, N., Lehtimaki, T., Hutri-Kahonen, N., Sahota, P., Juonala, M., & Raitakari, O. T. (2018). Cardiometabolic Health Among Adult Offspring of Hypertensive Pregnancies: The Cardiovascular Risk in Young Finns Study [Journal Article]. J Am Heart Assoc, 7(1). https://doi.org/10.1161/JAHA.117.006284
  650. Tapp, R. J., Hussain, S. M., Battista, J., Hutri-Kahonen, N., Lehtimaki, T., Hughes, A. D., Thom, S. A., Metha, A., Raitakari, O. T., & Kahonen, M. (2015). Impact of blood pressure on retinal microvasculature architecture across the lifespan: the Young Finns Study [Journal Article]. Microcirculation, 22(2), 146–155. https://doi.org/10.1111/micc.12187
  651. Tapp, R. J., Ness, A., Williams, C., Howe, L. D., Tilling, K., Witt, N., Chaturvedi, N., McG., T. S. A., & Hughes, A. D. (2013). Differential effects of adiposity and childhood growth trajectories on retinal microvascular architecture [Journal Article]. Microcirculation, 20(7), 609–616. https://doi.org/10.1111/micc.12060
  652. Tapp, R. J., Sharp, A., Stanton, A. V., O’Brien, E., Chaturvedi, N., Poulter, N. R., Sever, P. S., Thom, S. A., Hughes, A. D., & Mayet, J. (2010). Differential effects of antihypertensive treatment on left ventricular diastolic function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy [Journal Article]. J Am Coll Cardiol, 55(17), 1875–1881. https://doi.org/10.1016/j.jacc.2009.11.084
  653. Tapp, R. J., Williams, C., Witt, N., Chaturvedi, N., Evans, R., Thom, S. A., Hughes, A. D., & Ness, A. (2007). Impact of size at birth on the microvasculature: the Avon Longitudinal Study of Parents and Children [Journal Article]. Pediatrics, 120(5), e1225–8. https://doi.org/10.1542/peds.2006-2951
  654. Tapp, R. J., Witt, N., Chaturvedi, N., Evans, R., Thom, S. A., Hughes, A. D., Ness, A., & Williams, C. (2008). In Reply [Journal Article]. Pediatrics, 121(4). https://doi.org/10.1542/peds.2008-0099
  655. Tapp, R. J., Witt, N., Chaturvedi, N., Evans, R., Thom, S. A., Hughes, A. D., Ness, A., & Williams, C. (2008). Low birth weight and retinal vascular caliber in young children - Reply [Journal Article]. Pediatrics, 121(4), 863. https://doi.org/10.1542/peds.2008-0099
  656. Tarkin, J. M., Nijjer, S., Sen, S., Petraco, R., Echavarria-Pinto, M., Asress, K. N., Lockie, T., Khawaja, M. Z., Mayet, J., Hughes, A. D., Malik, I. S., Mikhail, G. W., Baker, C. S., Foale, R. A., Redwood, S., Francis, D. P., Escaned, J., & Davies, J. E. (2013). Hemodynamic response to intravenous adenosine and its effect on fractional flow reserve assessment: results of the Adenosine for the Functional Evaluation of Coronary Stenosis Severity (AFFECTS) study [Journal Article]. Circ Cardiovasc Interv, 6(6), 654–661. https://doi.org/10.1161/CIRCINTERVENTIONS.113.000591
  657. Taylor, C., Tillin, T., Chaturvedi, N., Dewey, M., Ferri, C. P., Hughes, A., Prince, M., Richards, M., Shah, A., & Stewart, R. (2013). Midlife hypertensive status and cognitive function 20 years later: the Southall and Brent revisited study [Journal Article]. J Am Geriatr Soc, 61(9), 1489–1498. https://doi.org/10.1111/jgs.12416
  658. Taylor, H. C. M., Chaturvedi, N., Davey Smith, G., Ferreira, D. L. S., Fraser, A., Howe, L. D., Hughes, A. D., Lawlor, D. A., Timpson, N. J., & Park, C. M. (2023). Is Height(2.7) Appropriate for Indexation of Left Ventricular Mass in Healthy Adolescents? The Importance of Sex Differences [Journal Article]. Hypertension, 80(10), 2033–2042. https://doi.org/10.1161/HYPERTENSIONAHA.121.17109
  659. Thom, S., Hughes, A., Martin, G., Nielsen, H., Inkpen, P., Schachter, M., & Sever, P. (1988). Peptides in Human Peripheral Vasculature [Journal Article]. Regulatory Peptides, 22(4), 434–434. https://doi.org/Doi 10.1016/0167-0115(88)90211-X
  660. Thom, S., Hughes, A., Martin, G., Redman, D., Goldberg, P., & Sever, P. (1986). The effect of vasodilator peptides in vivo and in vitro in man [Journal Article]. J Hypertens, 4, S626–S628.
  661. Thom, S., Hughes, A., Martin, G., & Sever, P. S. (1987). Endothelium-dependent relaxation in isolated human arteries and veins [Journal Article]. Clin Sci (Lond), 73(5), 547–552. https://doi.org/10.1042/cs0730547
  662. Thom, S., Hughes, A., Schachter, M., & Sever, P. (1992). Celiprolol. [Journal Article]. Lancet, 339(8787), 247. http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=1346201&retmode=ref&cmd=prlinks http://ac.els-cdn.com/0140673692900514/1-s2.0-0140673692900514-main.pdf?_tid=b81da312-4571-11e4-855f-00000aab0f01&acdnat=1411731725_d12fab89c4c56f6c87a5f0b3451c2e6f
  663. Thom, S., Stettler, C., Stanton, A., Witt, N., Tapp, R., Chaturvedi, N., Allemann, S., Mayet, J., Sever, P., Poulter, N., O’Brien, E., & Hughes, A. (2009). Differential effects of antihypertensive treatment on the retinal microcirculation: an anglo-scandinavian cardiac outcomes trial substudy [Journal Article]. Hypertension, 54(2), 405–408. https://doi.org/10.1161/HYPERTENSIONAHA.109.133819
  664. Thom, S. A., Hughes, A. D., Martin, G. N., & Sever, P. S. (1985). The release of the endothelium derived relaxing factor from isolated human arteries [Journal Article]. J Hypertens Suppl, 3(3), S97–9. https://www.ncbi.nlm.nih.gov/pubmed/2856828
  665. Thom, S. A. M., Mistry, P., Sjolie, A., Larsen, B., Witt, N., & Hughes, A. D. (2004). Retinal vascular adaptations to blood pressure are impaired in Type 1 diabetes [Journal Article]. Diabetologia, 47, A49–A49. ://WOS:000223951600127 https://link.springer.com/content/pdf/10.1007%2Fs00125-004-1401-z.pdf</span></li>
  666. Thom, S. M., Hughes, A. D., Goldberg, P., Martin, G., Schachter, M., & Sever, P. S. (1987). The Actions of Calcitonin Gene Related Peptide and Vasoactive-Intestinal-Peptide as Vasodilators in Man Invivo and Invitro [Journal Article]. Br J Clin Pharmacol, 24(2), 139–144. https://doi.org/10.1111/j.1365-2125.1987.tb03154.x
  667. Thomas, O., Salman, S., Hughes, A., Maddock, J., & James, S. (2023). An analysis of sodium intake throughout adulthood on later-life cognition [Journal Article]. Clinical Science, 137, A7.
  668. Thornton, G. D., McKenna, M., Bennett, J., Hughes, A., Gonzalez, A., Khanji, M. Y., Cavalcante, J. L., Lloyd, G., Moon, J. C., Bhattacharyya, S., & Treibel, T. A. (2025). Myocardial Remodelling in Aortic Regurgitation: Time to Think Beyond Volumes and Function? [Journal Article]. Eur Heart J Cardiovasc Imaging. https://doi.org/10.1093/ehjci/jeaf264
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  670. Tillin, T., Dhutia, H., Chambers, J., Malik, I., Coady, E., Mayet, J., Wright, A., Kooner, J., Chaturvedi, N., & Hughes, A. (2006). South Asians have narrower coronary arteries and different remodelling responses to disease compared to white Europeans [Journal Article]. Atherosclerosis Supplements, 7(3), 80. https://doi.org/10.1016/S1567-5688(06)80290-4
  671. Tillin, T., Dhutia, H., Chambers, J., Malik, I., Coady, E., Mayet, J., Wright, A. R., Kooner, J., Shore, A., Thom, S., Chaturvedi, N., & Hughes, A. (2008). South Asian men have different patterns of coronary artery disease when compared with European men [Journal Article]. Int J Cardiol, 129(3), 406–413. https://doi.org/10.1016/j.ijcard.2007.07.129
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  673. Tillin, T., Hughes, A. D., Godsland, I. F., Whincup, P., Forouhi, N. G., Welsh, P., Sattar, N., McKeigue, P. M., & Chaturvedi, N. (2013). Insulin resistance and truncal obesity as important determinants of the greater incidence of diabetes in Indian Asians and African Caribbeans compared with Europeans: the Southall And Brent REvisited (SABRE) cohort [Journal Article]. Diabetes Care, 36(2), 383–393. https://doi.org/10.2337/dc12-0544
  674. Tillin, T., Hughes, A. D., Mayet, J., Whincup, P., Sattar, N., Forouhi, N. G., McKeigue, P. M., & Chaturvedi, N. (2013). The relationship between metabolic risk factors and incident cardiovascular disease in Europeans, South Asians, and African Caribbeans: SABRE (Southall and Brent Revisited) – a prospective population-based study [Journal Article]. J Am Coll Cardiol, 61(17), 1777–1786. https://doi.org/10.1016/j.jacc.2012.12.046
  675. Tillin, T., Hughes, A. D., Wang, Q., Wurtz, P., Ala-Korpela, M., Sattar, N., Forouhi, N. G., Godsland, I. F., Eastwood, S. V., McKeigue, P. M., & Chaturvedi, N. (2015). Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study [Journal Article]. Diabetologia, 58(5), 968–979. https://doi.org/10.1007/s00125-015-3517-8
  676. Tillin, T., Hughes, A. D., Whincup, P., Mayet, J., Sattar, N., McKeigue, P. M., & Chaturvedi, N. (2014). Ethnicity and prediction of cardiovascular disease: performance of QRISK2 and Framingham scores in a U.K. tri-ethnic prospective cohort study (SABRE–Southall And Brent REvisited) [Journal Article]. Heart, 100(1), 60–67. https://doi.org/10.1136/heartjnl-2013-304474
  677. Tillin, T., Hughes, A. D., Whincup, P., Mayet, J., Sattar, N., McKeigue, P. M., & Chaturvedi, N. (2014). QRISK2 validation by ethnic group [Journal Article]. Heart, 100(5), 437. https://doi.org/10.1136/heartjnl-2013-305333
  678. Tillin, T., Sattar, N., Forouhi, N., Hughes, A. D., & Chaturvedi, N. (2014). Comment on Shah et al. Cardiovascular complications and mortality after diabetes diagnosis for South Asian and Chinese patients: a population-based cohort study. Diabetes care 2013;36:2670-2676 [Journal Article]. Diabetes Care, 37(4), e78–9. https://doi.org/10.2337/dc13-2490
  679. Tillin, T., Sattar, N., Godsland, I. F., Hughes, A. D., Chaturvedi, N., & Forouhi, N. G. (2015). Ethnicity-specific obesity cut-points in the development of Type 2 diabetes - a prospective study including three ethnic groups in the United Kingdom [Journal Article]. Diabet Med, 32(2), 226–234. https://doi.org/10.1111/dme.12576
  680. Tillin, T., Tuson, C., Sowa, B., Chattopadhyay, K., Sattar, N., Welsh, P., Roberts, I., Ebrahim, S., Kinra, S., Hughes, A., & Chaturvedi, N. (2019). Yoga and Cardiovascular Health Trial (YACHT): a UK-based randomised mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary event [Journal Article]. BMJ Open, 9(11), e030119. https://doi.org/10.1136/bmjopen-2019-030119
  681. Timmons, J. G., Greenlaw, N., Boyle, J. G., Chaturvedi, N., Ford, I., Brouwers, M., Tillin, T., Hramiak, I., Hughes, A. D., Jenkins, A. J., Klein, B. E. K., Klein, R., Ooi, T. C., Rossing, P., Stehouwer, C. D. A., Sattar, N., Colhoun, H. M., Petrie, J. R., & Group, R. S. (2021). Metformin and carotid intima-media thickness in never-smokers with type 1 diabetes: The REMOVAL trial [Journal Article]. Diabetes Obes Metab, 23(6), 1371–1378. https://doi.org/10.1111/dom.14350
  682. Timpka, S., Hughes, A. D., Chaturvedi, N., Franks, P. W., Lawlor, D. A., Rich-Edwards, J. W., & Fraser, A. (2019). Birth weight and cardiac function assessed by echocardiography in adolescence: Avon Longitudinal Study of Parents and Children [Journal Article]. Ultrasound Obstet Gynecol, 54(2), 225–231. https://doi.org/10.1002/uog.20128
  683. Timpka, S., Macdonald-Wallis, C., Hughes, A. D., Chaturvedi, N., Franks, P. W., Lawlor, D. A., & Fraser, A. (2016). Hypertensive Disorders of Pregnancy and Offspring Cardiac Structure and Function in Adolescence [Journal Article]. J Am Heart Assoc, 5(11). https://doi.org/10.1161/jaha.116.003906
  684. Toma, C., Jensen, P. E., Prieto, D., Hughes, A., Mulvany, M. J., & Aalkjaer, C. (1995). Effects of tyrosine kinase inhibitors on the contractility of rat mesenteric resistance arteries [Journal Article]. Br J Pharmacol, 114(6), 1266–1272. https://doi.org/10.1111/j.1476-5381.1995.tb13342.x
  685. Topriceanu, C., Alfarih, M., Hughes, A. D., Shiwani, H., Chan, F., Saidi A. Mohiddin, S. A., Moody, W., Steeds, R. P., O’Brien, B., Vowinckel, J., Syrris, P., Coats, C., Pettit, S., Arbustini, E., Moon, J. C., & Captur, G. (2023). The atrial and ventricular myocardial proteome of endstage lamin heart disease [Journal Article]. Acta Myologica, 42(2-3), 43–52. https://doi.org/https://doi.org/10.36185/2532-1900-339
  686. Topriceanu, C., Weber, M., Fiona, C., Moon, J. C., Chaturvedi, N., Hughes, A. D., Schott, J., Richards, M., & Captur, G. (2022). Heterozygous APOE ε4 carriage associates with improved myocardial efficiency in older age [Journal Article]. European Heart Journal, 43(Supplement_2). https://doi.org/10.1093/eurheartj/ehac544.2243
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  689. Topriceanu, C. C., Moon, J. C., Hardy, R., Chaturvedi, N., Hughes, A. D., & Captur, G. (2021). Longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function [Journal Article]. Sci Rep, 11(1), 6272. https://doi.org/10.1038/s41598-021-85435-8
  690. Topriceanu, C. C., Moon, J. C., Hardy, R., Hughes, A. D., & Captur, G. (2021). Childhood Bradycardia Associates With Atrioventricular Conduction Defects in Older Age: A Longitudinal Birth Cohort Study [Journal Article]. J Am Heart Assoc, e021877. https://doi.org/10.1161/JAHA.121.021877
  691. Topriceanu, C. C., Shah, M., Webber, M., Chan, F., Shiwani, H., Richards, M., Schott, J., Chaturvedi, N., Moon, J. C., Hughes, A. D., Hingorani, A. D., O’Regan, D. P., & Captur, G. (2024). APOE epsilon4 carriage associates with improved myocardial performance from adolescence to older age [Journal Article]. BMC Cardiovasc Disord, 24(1), 172. https://doi.org/10.1186/s12872-024-03808-z
  692. Topriceanu, C. C., Wong, A., Moon, J. C., Hughes, A. D., Bann, D., Chaturvedi, N., Patalay, P., Conti, G., & Captur, G. (2021). Evaluating access to health and care services during lockdown by the COVID-19 survey in five UK national longitudinal studies [Journal Article]. BMJ Open, 11(3), e045813. https://doi.org/10.1136/bmjopen-2020-045813
  693. Topriceanu, C. C., Wong, A., Moon, J. C., Hughes, A. D., Chaturvedi, N., Conti, G., Bann, D., Patalay, P., & Captur, G. (2021). Impact of lockdown on key workers: findings from the COVID-19 survey in four UK national longitudinal studies [Journal Article]. J Epidemiol Community Health, 75(10), 955–962. https://doi.org/10.1136/jech-2020-215889
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  752. Williams, B., Lacy, P. S., Cruickshank, J. K., Collier, D., Hughes, A. D., Stanton, A., Thom, S., & Thurston, H. (2009). Impact of statin therapy on central aortic pressures and hemodynamics: principal results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study [Journal Article]. Circulation, 119(1), 53–61. https://doi.org/10.1161/CIRCULATIONAHA.108.785915
  753. Williams, B., Lacy, P. S., Thom, S. M., Cruickshank, K., Stanton, A., Collier, D., Hughes, A. D., Thurston, H., & O’Rourke, M. (2006). Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study [Journal Article]. Circulation, 113(9), 1213–1225. https://doi.org/10.1161/CIRCULATIONAHA.105.595496
  754. Williams, B., Lacy, P. S., Thurston, H., Thom, S., Hughes, A., Cruickshank, K., Stanton, A., Collier, D., & O’Rourke, M. (2006). Response to letters regarding article, "differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: Principal results of the Conduit Artery Function Evaluation (CAFE) Study" [Journal Article]. Circulation, 114(15), E540–E541. https://doi.org/10.1161/Circulationaha.106.640870
  755. Williams, E. D., Eastwood, S. V., Tillin, T., Hughes, A. D., & Chaturvedi, N. (2014). The effects of weight and physical activity change over 20 years on later-life objective and self-reported disability [Journal Article]. Int J Epidemiol, 43(3), 856–865. https://doi.org/10.1093/ije/dyu013
  756. Williams, E. D., Eastwood, S. V., Tillin, T., Stewart, R., Chaturvedi, N., & Hughes, A. D. (2015). Statin use is associated with reduced depressive symptoms in Europeans, but increased symptoms in ethnic minorities in the UK: an observational study [Journal Article]. Br J Clin Pharmacol, 80(1), 172–173. https://doi.org/10.1111/bcp.12599
  757. Williams, E. D., Tillin, T., Richards, M., Tuson, C., Chaturvedi, N., Hughes, A. D., & Stewart, R. (2015). Depressive symptoms are doubled in older British South Asian and Black Caribbean people compared with Europeans: associations with excess co-morbidity and socioeconomic disadvantage [Journal Article]. Psychol Med, 45(9), 1861–1871. https://doi.org/10.1017/S0033291714002967
  758. Williams, K., Jamieson, A., Chaturvedi, N., Hughes, A., & Orini, M. (2023). Validation of Wearable Derived Heart Rate Variability and Oxygen Saturation from the Garmin’s Health Snapshot [Conference Paper]. https://doi.org/10.22489/CinC.2023.237
  759. Wimalasundera, R., Fexby, S., Regan, L., Thom, S. A., & Hughes, A. D. (2003). Effect of tumour necrosis factor-alpha and interleukin 1beta on endothelium-dependent relaxation in rat mesenteric resistance arteries in vitro [Journal Article]. Br J Pharmacol, 138(7), 1285–1294. https://doi.org/10.1038/sj.bjp.0705168
  760. Wimalasundera, R. C., Larbalestier, N., Smith, J. H., de Ruiter, A., Mc, G. T. S. A., Hughes, A. D., Poulter, N., Regan, L., & Taylor, G. P. (2002). Pre-eclampsia, antiretroviral therapy, and immune reconstitution [Journal Article]. Lancet, 360(9340), 1152–1154. https://doi.org/10.1016/S0140-6736(02)11195-0
  761. Wimalasundera, R. C., Mc, G. T. S. A., Regan, L., & Hughes, A. D. (2002). Action of the endothelin receptor (ETA) antagonist BQ-123 on forearm blood flow in young normotensive subjects [Journal Article]. Clin Sci (Lond), 102(6), 661–666. https://doi.org/10.1042/
  762. Wimalasundera, R. C., Thom, S. A., Regan, L., & Hughes, A. D. (2005). Effects of vasoactive agents on intracellular calcium and force in myometrial and subcutaneous resistance arteries isolated from preeclamptic, pregnant, and nonpregnant woman [Journal Article]. Am J Obstet Gynecol, 192(2), 625–632. https://doi.org/10.1016/j.ajog.2004.07.040
  763. Wimalasundera, R. C., Wijetunge, S., Thom, S. M., Regan, L., & Hughes, A. D. (2010). Impaired recovery of intracellular calcium and force after activation in isolated myometrial and subcutaneous resistance arteries from women with preeclampsia [Journal Article]. J Hypertens, 28(3), 568–574. https://doi.org/10.1097/HJH.0b013e328334f20b
  764. Winpenny, E., Stochl, J., Hughes, A., Tilling, K., & Howe, L. D. (2024). How do socioeconomic trajectories experienced during early adulthood contribute to the development of cardiometabolic health in young adults? [Journal Article]. MedRxiv, 2024.09.02.24312850. https://doi.org/10.1101/2024.09.02.24312850
  765. Witt, N., Wong, T. Y., Hughes, A. D., Chaturvedi, N., Klein, B. E., Evans, R., McNamara, M., Thom, S. A., & Klein, R. (2006). Abnormalities of retinal microvascular structure and risk of mortality from ischemic heart disease and stroke [Journal Article]. Hypertension, 47(5), 975–981. https://doi.org/10.1161/01.HYP.0000216717.72048.6c
  766. Witt, N. W., Chapman, N., Thom, S. A., Stanton, A. V., Parker, K. H., & Hughes, A. D. (2010). A novel measure to characterise optimality of diameter relationships at retinal vascular bifurcations [Journal Article]. Artery Res, 4(3), 75–80. https://doi.org/10.1016/j.artres.2010.06.003
  767. Witt, N. W., Martinez-Perez, M. E., Parker, K. H., Thom, S. A., & Hughes, A. D. (2009). Geometrical and topological analysis of vascular branches from fundus retinal images [Book Section]. In H. F. Jelinek & M. J. Cree (Eds.), Automated Image Detection of Retinal Pathology. CRC Press. https://doi.org/10.1201/9781420037005.ch10
  768. Wood, N. B., Exarchou, I., Xu, X. Y., Mistry, P., Witt, N., Thom, S. A., & Hughes, A. D. Progress with the study of retinal hemodynamics in normotensive and hypertensive patients [Conference Proceedings]. Proceedings of the 2005 Summer Bioengineering Conference, 2005, 259–260. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646562503&partnerID=MN8TOARS
  769. Wood, N. B., Zhao, S. Z., Zambanini, A., Jackson, M., Gedroyc, W., Thom, S. A., Hughes, A. D., & Xu, X. Y. (2006). Curvature and tortuosity of the superficial femoral artery: a possible risk factor for peripheral arterial disease [Journal Article]. J Appl Physiol (1985), 101(5), 1412–1418. https://doi.org/10.1152/japplphysiol.00051.2006
  770. Wood, N. B., Zhao, S. Z., Zambanini, A., Xu, X. Y., Jackson, M., Thom, S. A., & Hughes, A. D. (2005). Increased curvature and tortuosity of the superficial femoral artery in males: a risk factor for peripheral vascular disease? [Journal Article]. International Conference on Computational Bioengineering, 1–7.
  771. Wurtz, P., Havulinna, A. S., Soininen, P., Tynkkynen, T., Prieto-Merino, D., Tillin, T., Ghorbani, A., Artati, A., Wang, Q., Tiainen, M., Kangas, A. J., Kettunen, J., Kaikkonen, J., Mikkila, V., Jula, A., Kahonen, M., Lehtimaki, T., Lawlor, D. A., Gaunt, T. R., … Salomaa, V. (2015). Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts [Journal Article]. Circulation, 131(9), 774–785. https://doi.org/10.1161/CIRCULATIONAHA.114.013116
  772. Wurtz, P., Wang, Q., Soininen, P., Kangas, A. J., Fatemifar, G., Tynkkynen, T., Tiainen, M., Perola, M., Tillin, T., Hughes, A. D., Mantyselka, P., Kahonen, M., Lehtimaki, T., Sattar, N., Hingorani, A. D., Casas, J. P., Salomaa, V., Kivimaki, M., Jarvelin, M. R., … Ala-Korpela, M. (2016). Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase [Journal Article]. J Am Coll Cardiol, 67(10), 1200–1210. https://doi.org/10.1016/j.jacc.2015.12.060
  773. Xie, L., Clunn, G. F., Lymn, J. S., & Hughes, A. D. (1998). Role of intracellular calcium ([Ca2+](i)) and tyrosine phosphorylation in adhesion of cultured vascular smooth muscle cells to fibrinogen [Journal Article]. Cardiovasc Res, 39(2), 475–484. https://doi.org/10.1016/S0008-6363(98)00079-0
  774. Xu, X. Y., Zhao, S. Z., Ariff, B., Long, Q., Hughes, A. D., & Thom, S. A. CFD and FE stress analysis of the carotid bifurcation based on individual anatomical and flow data acquired using MRI and ultrasound [Conference Proceedings]. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, 50, 621–622. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242609848&partnerID=MN8TOARS
  775. Zambanini, A., Cunningham, S. L., Parker, K. H., Khir, A. W., Mc, G. T. S. A., & Hughes, A. D. (2005). Wave-energy patterns in carotid, brachial, and radial arteries: a noninvasive approach using wave-intensity analysis [Journal Article]. Am J Physiol Heart Circ Physiol, 289(1), H270–6. https://doi.org/10.1152/ajpheart.00636.2003
  776. Zambanini, A., Khir, A. W., Byrd, S. M., Parker, K. H., Thom, S. A. M., & Hughes, A. D. (2002). Wave intensity analysis: a novel non-invasive method for determining arterial wave transmission [Book Section]. In Computers in Cardiology (Vol. 29, pp. 717–720). ://WOS:000181394600182</span></li>
  777. Zhang, X., Luckham, P. F., Hughes, A. D., Thom, S., & Xu, X. Y. (2011). Development of lysolipid-based thermosensitive liposomes for delivery of high molecular weight proteins [Journal Article]. Int J Pharm, 421(2), 291–292. https://doi.org/10.1016/j.ijpharm.2011.09.016
  778. Zhang, X., Luckham, P. F., Hughes, A. D., Thom, S., & Xu, X. Y. (2013). Towards an understanding of the release behavior of temperature-sensitive liposomes: a possible explanation of the "pseudoequilibrium" release behavior at the phase transition temperature [Journal Article]. J Liposome Res, 23(3), 167–173. https://doi.org/10.3109/08982104.2013.779702
  779. Zhao, S. Z., Ariff, B., Long, Q., Hughes, A. D., Thom, S. A., Stanton, A. V., & Xu, X. Y. (2002). Inter-individual variations in wall shear stress and mechanical stress distributions at the carotid artery bifurcation of healthy humans. [Journal Article]. J Biomech, 35(10), 1367–1377. https://doi.org/Pii S0021-9290(02)00185-9 Doi 10.1016/S0021-9290(02)00185-9
  780. Zhao, S. Z., Xu, X. Y., Collins, M. W., Stanton, A. V., Hughes, A. D., & Thom, S. A. (1999). The convergence technique in numerical solutions of coupled fluid-wall problems [Book Section]. In S. Sajjadi, G. B. Nash, & M. W. Rampling (Eds.), Cardiovascular Flow Modelling and Measurement with Application to Clinical Medicine (Vol. 70, pp. 125–134). OUP. ://WOS:000088999100011</span></li>
  781. Zhao, S. Z., Xu, X. Y., Collins, M. W., Stanton, A. V., Hughes, A. D., & Thom, S. A. (1999). Flow in carotid bifurcations: effect of the superior thyroid artery [Journal Article]. Med Eng Phys, 21(4), 207–214. https://doi.org/10.1016/S1350-4533(99)00046-6
  782. Zhao, S. Z., Xu, X. Y., Hughes, A. D., Thom, S. A., Stanton, A. V., Ariff, B., & Long, Q. (2000). Blood flow and vessel mechanics in a physiologically realistic model of a human carotid arterial bifurcation [Journal Article]. J Biomech, 33(8), 975–984. https://doi.org/10.1016/S0021-9290(00)00043-9
    783. </ol> </div>